pH-Responsive, Lysine-Based, Hyperbranched Polymers Mimicking Endosomolytic Cell-Penetrating Peptides for Efficient Intracellular Delivery

Wang, Shiqi; Chen, Rongjun

doi:10.1021/acs.chemmater.7b00054

Cited by 28 publications

(24 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chen et al used a polycondensation reaction involving A2 + B3 + B2 monomers, and showed that the resulting hyperbranched polymers had high cellular internalisation rates which were dependent on pH. 123 The branched architectures enhanced the membrane lytic properties of the polymers compared to the linear version, and thus showed potential for cytoplasmic delivery of therapeutic molecules.…”

Section: Step Growth Polymerisation Of A2+bm Monomersmentioning

confidence: 99%

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Cook

Perrier

2019

Adv Funct Materials

129

View full text Add to dashboard Cite

Barriers to therapeutic transport in biological systems can prevent accumulation of drugs at the intended site, thus limiting the therapeutic effect against various diseases. Advances in synthetic chemistry techniques have recently increased the accessibility of complex polymer architectures for drug delivery systems, including branched polymer architectures. This article first outlines drug delivery concepts, and then defines and illustrates all forms of branched polymers including highly branched polymers, hyperbranched polymers, dendrimers, and branched–linear hybrid polymers. Many new types of branched and dendritic polymers continue to be reported; however, there is often confusion about how to accurately describe these complex polymer architectures, particularly in the interdisciplinary field of nanomedicine where not all researchers have in‐depth polymer chemistry backgrounds. In this context, the present review describes and compares different branched polymer architectures and their application in therapeutic delivery in a simple and easy‐to‐understand way, with the aim of appealing to a multidisciplinary audience.

show abstract

Section: Step Growth Polymerisation Of A2+bm Monomersmentioning

confidence: 99%

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Cook

Perrier

2019

Adv Funct Materials

129

View full text Add to dashboard Cite

show abstract

“…In such an environment, the external anionic layer degrades and enhances endosomolytic electrostatic interactions, in addition to the proton-sponge effect [ 283 , 284 ]. Alternatively, anionic pH-sensitive polymers containing weak acidic groups and hydrophobic moieties (e.g., poly(acrylic acid)-derivatives, poly(malic acid)-derivatives and L-phenylalanine-grafted poly(L-lysine iso-phthalamide)) can also be exploited due to their membrane disruptive capabilities upon luminal acidification [ 285 , 286 , 287 , 288 ]. In this regard, at pH values below their pKa, the polymers undergo a conformational change from an extended charged configuration to a globular hydrophobic one.…”

Section: Enhancing Ion Endosomal Escapementioning

confidence: 99%

Tailoring Iron Oxide Nanoparticles for Efficient Cellular Internalization and Endosomal Escape

et al. 2020

View full text Add to dashboard Cite

Iron oxide nanoparticles (IONs) have been widely explored for biomedical applications due to their high biocompatibility, surface-coating versatility, and superparamagnetic properties. Upon exposure to an external magnetic field, IONs can be precisely directed to a region of interest and serve as exceptional delivery vehicles and cellular markers. However, the design of nanocarriers that achieve an efficient endocytic uptake, escape lysosomal degradation, and perform precise intracellular functions is still a challenge for their application in translational medicine. This review highlights several aspects that mediate the activation of the endosomal pathways, as well as the different properties that govern endosomal escape and nuclear transfection of magnetic IONs. In particular, we review a variety of ION surface modification alternatives that have emerged for facilitating their endocytic uptake and their timely escape from endosomes, with special emphasis on how these can be manipulated for the rational design of cell-penetrating vehicles. Moreover, additional modifications for enhancing nuclear transfection are also included in the design of therapeutic vehicles that must overcome this barrier. Understanding these mechanisms opens new perspectives in the strategic development of vehicles for cell tracking, cell imaging and the targeted intracellular delivery of drugs and gene therapy sequences and vectors.

show abstract

“…Recently, an anionic, Lys-based hyperbranched polymer mimicking peptides are developed for overcoming the barrier in the case of delivery of drugs to cytoplasm. These novel carriers altered conformation according to pH together with its multivalence effect to facilitate the complete membrane disruption at late endosomal pH (Figure 15) [209].…”

Section: Ph-responsive Drug Release At the Cellular Levelmentioning

confidence: 99%

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

et al. 2019

View full text Add to dashboard Cite

Smart nano-carriers have attained great significance in the biomedical field due to their versatile and interesting designs with different functionalities. The initial stages of the development of nanocarriers mainly focused on the guest loading efficiency, biocompatibility of the host and the circulation time. Later the requirements of less side effects with more efficacy arose by attributing targetability and stimuli-responsive characteristics to nano-carriers along with their bio- compatibility. Researchers are utilizing many stimuli-responsive polymers for the better release of the guest molecules at the targeted sites. Among these, pH-triggered release achieves increasing importance because of the pH variation in different organ and cancer cells of acidic pH. This specific feature is utilized to release the guest molecules more precisely in the targeted site by designing polymers having specific functionality with the pH dependent morphology change characteristics. In this review, we mainly concert on the pH-responsive polypeptides and some interesting nano-carrier designs for the effective theranostic applications. Also, emphasis is made on pharmaceutical application of the different nano-carriers with respect to the organ, tissue and cellular level pH environment.

show abstract

pH-Responsive, Lysine-Based, Hyperbranched Polymers Mimicking Endosomolytic Cell-Penetrating Peptides for Efficient Intracellular Delivery

Cited by 28 publications

References 46 publications

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Tailoring Iron Oxide Nanoparticles for Efficient Cellular Internalization and Endosomal Escape

pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications

Contact Info

Product

Resources

About