pH-Responsive Magnetic Mesoporous Silica-Based Nanoplatform for Synergistic Photodynamic Therapy/Chemotherapy

Abstract

By overcoming drug resistance and subsequently enhancing the treatment, the combination therapy of photodynamic therapy (PDT) and chemotherapy has promising potential for cancer treatment. However, the major challenge is how to establish an advanced nanoplatform that can be efficiently guided to tumor sites and can then stably release both chemotherapy drugs and a photosensitizer simultaneously and precisely. In this study, which considered the possibility and targeting efficiency of a magnetic targeting strategy, a novel FeO@mSiO(DOX)@HSA(Ce6) nanoplatform was successfully built; this platform could be employed as an efficient synergistic antitumor nanoplatform with magnetic guidance for highly specific targeting and retention. Doxorubicin (DOX) molecules were loaded into mesoporous silica with high loading capability, and the mesoporous channels were blocked by a polydopamine coating. Human serum albumin (HSA) was conjugated to the outer surface to increase the biocompatibility and blood circulation time, as well as to provide a vehicle for loading photosensitizer chlorin e6 (Ce6). The sustained release of DOX under acidic conditions and the PDT induced by red light exerted a synergistic inhibitory effect on glioma cells. Our experiments demonstrated that the pH-responsive FeO@mSiO(DOX)@HSA(Ce6) nanoplatform was guided to the tumor region by magnetic targeting and that the nanoplatform suppressed glioma tumor growth efficiently, implying that the system is a highly promising photodynamic therapy/chemotherapy combination nanoplatform with synergistic effects for cancer treatment.

Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines

“…40% and 20% in 60 min, respectively (Figure 9). Despite the absence of a total release of DOX from our nanocarrier, these values are quite similar to the ones obtained by Tang et al [38], where a Magnetic Mesoporous Silica nanoplatform had a cumulative DOX release of ca. of 45% and 20% at pH 6.0 and pH 7.4 at 60 min, respectively.…”

Preparation of iron oxide mesoporous magnetic microparticles as novel multidrug carriers for synergistic anticancer therapy and deep tumor penetration

“…Hence, use of biocompatible systems for efficient delivery of hydrophilic/hydrophobic drugs or even combinatory drugs can provide maximal therapeutic effects with minimal negligent side effects. While co-delivering systems have been explored by precious works 7,31,67,68 , very few studies examined the use of iron oxide-based magnetic particles as drug delivery carriers for Tam 69–71 , and none as a combinatory chemo/hormonal therapeutic vehicle. Herein, simple adsorption of drugs onto IO-MMM mesostructures was chosen, as it has the advantage to preserve both the structure of the constructs and the loaded drugs.…”

Mesoporous Silica as a Versatile Platform for Cancer Immunotherapy

“…Owing to the versatility of mesoporous silica materials depending on various methods of synthesis, mesoporous silica has been utilized for combinatorial cancer therapy. Therapies have included photodynamic‐photothermal therapy, photodynamic‐chemotherapy, and gene‐chemotherapy . Chemo‐immunotherapy and photodynamic‐immunotherapy have recently been combined using advanced integrated mesoporous silica …”