pH-responsive magnetic nanocomposites based on poly(2-succinyloxyethyl methacrylate-co-methylmethacrylate) for anticancer doxorubicin delivery applications

Ghamkhari, Aliyeh; Agbolaghi, Samira; Poorgholy, Nahid; Massoumi, Bakhshali

doi:10.1007/s10965-017-1431-0

Cited by 9 publications

(1 citation statement)

References 35 publications

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“…It is well known that linear, graft, and cross-linked polymers [21,22] or peptide/ polymer conjugates [23] based on HEMA are attractive biomaterials for contact lenses, gene and drug delivery [24]. The biocompatible HEMA/MMA copolymers [25][26][27][28] have been extended by polymethacrylate segment with PEG grafts [29], grafted from the surface of TiO 2 nanoparticles [30], or modified to Fe 3 O 4 containing nanocomposite pH-responsive systems for anticancer drug delivery [31]. In our work, a new bioinitiator, that is retinol, modified with bromoester group was synthesized and applied in the atom transfer radical polymerization (ATRP) of methacrylate comonomers to achieve retinol endcapped P(HEMA-co-MMA)s with different content of hydroxy-functionalized units (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Retinol derivative as bioinitiator in the synthesis of hydroxyl-functionalized polymethacrylates for micellar delivery systems

Odrobińska¹,

Neugebauer²

2019

Express Polym. Lett.

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Amphiphilic copolymers containing 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA) units were synthesized by controlled atom transfer radical polymerization (ATRP) applying bromoester modified retinol (RETBr) as a novel initiator. Analogous series of copolymers with adjustable hydrophilic-hydrophobic balance was obtained with the use of a standard initiator, i.e. ethyl α-bromoisobutyrate (EBriB). The self-assembling particles, prepared by the solvent evaporation, were loaded with vitamin C (VitC) or ferulic acid (FA). The hydrophilic/hydrophobic ratio in the copolymer was indicated as a crucial factor to regulate efficiencies of encapsulation processes in the range of 53-98%. In vitro release of bioactive substance was carried out in phosphate buffer solution (PBS) at pH 7.4 with the maximum amount of VitC after 1h (27-62%) or FA within 2 h (71-97%). The polymeric systems with satisfactory encapsulation characteristics and release profiles are attractive micellar carriers of antioxidants, which, due to their activities could be also delivered using the popular approaches in cosmetology like masks, under-eye patches, or wraps.

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