pH-responsive metallo-supramolecular nanogel for synergistic chemo-photodynamic therapy

Yao, Xuemei; Chen, Li; Chen, Xiaofei; Xie, Zhigang; Ding, Jianxun; He, Chaoliang; Zhang, Jingping; Chen, Xuesi

doi:10.1016/j.actbio.2015.07.024

Cited by 40 publications

(26 citation statements)

References 40 publications

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“…Schematic illustrations of these nanosystems for drugs are shown in Figure 6. In addition, graphene oxide, 235 carbon nanotubes, 236,237 nanorods, 238 nanosponges, 239 solid lipid NPs, 240 nanometal-organic frameworks, 241 metallosupramolecular nanogels, 242 and microspheres 243 all provide new opportunities for the antitumor effects of TCM-combination therapy.…”

Section: Nanovesiclesmentioning

confidence: 99%

<p>Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment</p>

Fan

et al. 2019

IJN

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Cancer is a major public health problem, and is now the world's leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nanotargeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. In this review, the anticancer activity of TCM compounds is introduced. The combined use of TCM for antitumor treatment is analyzed and summarized. These combination therapies, using a single nanocarrier system, namely codelivery, are analyzed, issues that require attention are determined, and future perspectives are identified. We carried out a systematic review of .280 studies published in PubMed since 1985 (no patents involved), in order to provide a few basic considerations in terms of the design principles and management of targeted nanotechnology-based TCM-combination therapies.

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Section: Nanovesiclesmentioning

confidence: 99%

<p>Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment</p>

Fan

et al. 2019

IJN

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“…Another type of targeted therapy involves conditional response-induced PSs, which are released at a specific location. Given the abnormal pH conditions in tumor tissue, a pH-responsive PS modification is the most common conditional response modification, leading to preferential accumulation of PSs in tumor tissues [115, 116]. …”

Section: Novel Strategies In Pdt Of Osmentioning

confidence: 99%

A review and outlook in the treatment of osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep

Zhu

Wang

et al. 2017

Oncotarget

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Photodynamic therapy, one of the most promising minimally invasive treatments, has received increasing focus in tumor therapy research, which has been widely applied in treating superficial tumors. Three basic factors - photosensitizer, the light source, and oxidative stress - are responsible for tumor cell cytotoxicity. However, due to insufficient luminous flux and peripheral tissue damage, the utilization of photodynamic therapy is facing a huge limitation in deep tumor therapy. Osteosarcoma is the typical deep tumor, which is the most commonly occurring malignancy in children and adolescents. Despite developments in surgery, high risks of the amputation still threatens the health of osteosarcoma patients. In this review, we summarize recent developments in the field of photodynamic therapy and specifically PDT research in OS treatment modalities. In addition, we also provide some novel suggestions, which could potentially be a breakthrough in PDT-induced OS therapies. PDT has the potential to become an effective therapy while the its limitations still present when applied on the treatment of OS or other types of deep tumors. Thus, more researches and studies in the field are required.

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“…In the fabrication of intelligent drug delivery systems, supramolecular chemistry based on non‐covalent interactions has acted in key roles. Our group reported that two histidine moieties can bind to one metal porphyrin to form supramolecular micelles via metallo‐coordinated interactions in a physiological environment and this self‐assemble exhibits acid sensitivity . Herein, dextran (Dex) with good biocompatibility was chosen as the hydrophilic backbone to fabricate acid‐sensitive ROS‐triggered dual‐drug delivery systems for synergistic chemo‐photodynamic therapy via metallo‐coordinated interactions.…”

Section: Introductionmentioning

confidence: 99%

Acid‐sensitive reactive oxygen species triggered dual‐drug delivery systems for chemo‐photodynamic therapy to overcome multidrug resistance

Yin

Bao

Liu

et al. 2020

Polymer International

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In clinical treatment, multidrug resistance (MDR) is one of the major obstacles resulting in the failure of chemotherapy. It is still a challenge to overcome MDR. Herein, we fabricated intelligent dextran-based dual-drug delivery systems histidine modified dextran conjugated doxorubicin/zinc porphyrin/paclitaxel (DHTD/Zn-TPP/PTX) via supramolecular metallo-coordination for synergistic chemo-photodynamic therapy to overcome cancer drug resistance. In this designed DHTD/Zn-TPP/PTX, one anticancer drug (doxorubicin, DOX) was conjugated on the dextran backbone through a reactive oxygen species sensitive linker and the other drug PTX was encapsulated into the acid responsive supramolecular micelles formed by the photosensitizer Zn-TPP and histidine grafted on dextran. DHTD/Zn-TPP/PTX with excellent stability could be effectively internalized by tumour cells. In the acidic tumour environment, the loaded PTX and Zn-TPP as photosensitizer could be released; moreover, when irradiated with light the conjugated DOX could be specifically released because the linker broke. As the obtained data indicate, DHTD/Zn-TPP/PTX exhibited not only an enhanced anticancer therapeutic effect but also significant growth inhibition for drug-resistant MCF-7/ADR cells to reverse MDR, having great potential for synergistic treatments of cancer to overcome MDR.

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pH-responsive metallo-supramolecular nanogel for synergistic chemo-photodynamic therapy

Cited by 40 publications

References 40 publications

<p>Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment</p>

<p>Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment</p>

A review and outlook in the treatment of osteosarcoma and other deep tumors with photodynamic therapy: from basic to deep

Acid‐sensitive reactive oxygen species triggered dual‐drug delivery systems for chemo‐photodynamic therapy to overcome multidrug resistance

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