pH-responsive micelles composed of poly(ethylene glycol) and cholesterol-modified poly(monomethyl itaconate) as a nanocarrier for controlled and targeted release of piroxicam

Pourmoazzen, Zhaleh; Bagheri, Massoumeh; Entezami, Ali Akbar; Nejati-Koshki, Kazem

doi:10.1007/s10965-013-0295-1

Cited by 13 publications

(14 citation statements)

References 30 publications

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“…The pH-responsive hydrogel made of the PEG derivative and α,β-polyaspartylhydrazide was applied as a drug delivery system for anti-cancer drug doxorubicin [117]. The drug delivery system made of PEG and cholesterol-modified poly(monomethyl itaconate) showed a pH-responsive property and was used for controlled and targeted release of the model drug piroxicam, which was used in tumor-targeting chemotherapy [118]. The pH-responsive hydrogel from PEG and poly(itaconic acid) was developed using UV-initiated free radical polymerization with tetraethylene glycol as the cross-linking agent and Irgacure 2959 as the initiator and it was used as a drug delivery system for oral delivery of the drug [119].…”

Section: Synthetic Stimuli-responsive Polymersmentioning

confidence: 99%

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

2019

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This review describes some commercially available stimuli-responsive polymers of natural and synthetic origin, and their applications in drug delivery and textiles. The polymers of natural origin such as chitosan, cellulose, albumin, and gelatin are found to show both thermo-responsive and pH-responsive properties and these features of the biopolymers impart sensitivity to act differently under different temperatures and pH conditions. The stimuli-responsive characters of these natural polymers have been discussed in the review, and their respective applications in drug delivery and textile especially for textile-based transdermal therapy have been emphasized. Some practically important thermo-responsive polymers such as pluronic F127 (PF127) and poly(N-isopropylacrylamide) (pNIPAAm) of synthetic origin have been discussed in the review and they are of great importance commercially because of their in situ gel formation capacity. Some pH-responsive synthetic polymers have been discussed depending on their surface charge, and their drug delivery and textile applications have been discussed in this review. The selected stimuli-responsive polymers of synthetic origin are commercially available. Above all, the applications of bio-based or synthetic stimuli-responsive polymers in textile-based transdermal therapy are given special regard apart from their general drug delivery applications. A special insight has been given for stimuli-responsive hydrogel drug delivery systems for textile-based transdermal therapy, which is critical for the treatment of skin disease atopic dermatitis.

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Section: Synthetic Stimuli-responsive Polymersmentioning

confidence: 99%

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

2019

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“…Previous results showed that PEG can not only increase water solubility, but also help the micelles escape from undesired attacks in biological media such as blood serum, thereby prolonging the circulation time in vivo [18]. However, the PEG shells would also act as a steric barrier for contact between the polymeric micelles and the target cells, which might affect the efficiency of intracellular drug delivery.…”

Section: Synthesis and Characterization Of Amphiphilic Modified Hpcsmentioning

confidence: 99%

“…At temperatures above the LCST, the sizes of the micelles are increased due to the increase of their hydrophobic nature as well as their tendency for agglomeration. However, the existence of a PEG shell prevents further agglomeration and prevents the precipitation of agglomerates [18]. It has been demonstrated that the prevention of precipitation of thermosensitive micelles, which is caused by the higher temperature of tumor tissue, is a very effective factor in the delivery and uptake of thermoresponsive carriers [37].…”

Section: Self-assembly and Micellar Properties Of Biotinylated Modifimentioning

confidence: 99%

“…Polyethylene glycol (PEG) is a nontoxic and nonirritating hydrophilic polymer [3,14]. Owing to the steric hindrance of the PEG chains, PEGylation of nanoparticles has been proven to be an effective approach for improving the stability of the drug delivery system and extending circulation of the carrier in blood stream to overcome the uptake of polymer micelles by macrophages [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles as a nano-carrier for cancer-targeted drug delivery

et al. 2014

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In this article, we report the synthesis of a novel amphiphilic hydroxypropyl cellulose-based polymer (HPC-PEG-Chol) that contained poly (ethylene glycol) and cholesterol-containing moieties with specific degrees of substitution. The resulting polymer was subsequently converted to a biotin conjugate (HPC-PEG-Chol-biotin), to develop a new potential cancer-targeted drug delivery system. The biotin conjugate was used to prepare micelles via the dialysis method. The polymeric micelles in aqueous solution presented a lower critical solution temperature (LCST) of 39.8 o C. The critical micelle concentration (CMC) values of the polymeric micelles at 25 and 45°C were evaluated to be about 0.32 and 0. 25 g/L, respectively. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) analyses of the micelles revealed the spherical shapes of the micelles, with 84 nm mean diameters that increased with the increase of the temperature above LCST. The hydrophobic anticancer drug paclitaxel (PTX) was loaded in the micelles and the in vitro release behaviors of PTX were investigated at different temperatures. The release profile of PTX from the polymeric micelles revealed a thermosensitivity, since its release rate was higher at 41°C than at 37°C. Fluorescent microscopy analyses confirm that the PTX-loaded HPC-PEG-Cholbiotin is superior in cellular uptake, with very strong adsorption to both HeLa and MDA-MB-231 cancer cell lines. MTT assay in normal cells indicated that HPC-PEG-Chol-biotin micelles have great potential to be safely used in tumortargeting chemotherapy.

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“…Many functional gels have been developed and applied to biomaterials [1][2][3][4] such as artificial muscle, drug delivery system, tissue engineering, molecular recognition materials, biosensors, etc. The stimuli-responding mechanisms are mainly based on conformational changes of the polymer chains caused by environmental changes: e.g., temperature, pH, magnetic field, electric field, light, specific chemicals, etc.…”

Section: Introductionmentioning

confidence: 99%

Effect of initial substrate concentrations of the BZ reaction on self-oscillating of polymer chains with Fe(phen)3 catalyst

et al. 2015

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Self-oscillation for the poly(NIPAAm-coFe(phen) 3 ) solution induced by the Belousov-Zhabotinsky (BZ) reaction was studied by changing initial substrate concentrations (i.e., malonic acid, potassium bromate, and sulphuric acid) of the BZ reaction and the concentration of polymer solution. The results showed that the self-oscillation could be controlled by changing the initial substrate concentrations of polymer and potassium bromate. However, the oscillation behavior was insensitive to the concentration of malonic acid and sulphuric acid.

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pH-responsive micelles composed of poly(ethylene glycol) and cholesterol-modified poly(monomethyl itaconate) as a nanocarrier for controlled and targeted release of piroxicam

Cited by 13 publications

References 30 publications

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles as a nano-carrier for cancer-targeted drug delivery

Effect of initial substrate concentrations of the BZ reaction on self-oscillating of polymer chains with Fe(phen)3 catalyst

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