pH-responsive microparticles of rifampicin for augmented intramacrophage uptake and enhanced antitubercular efficacy

Lokhande, Amit S.; Panchal, Falguni; Munshi, Renuka; Madkaikar, Manisha; Malshe, V. C.; Devarajan, Padma V.

doi:10.1016/j.ijpharm.2023.122729

Cited by 3 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An analysis of the literature indicates that the drug release may vary depending on the physicochemical properties of the polymeric materials of the carrier, the chemical nature of the drug, and environmental parameters (pH, ionic strength of the solution, the presence/absence of enzymes, etc.) [32,127,128].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Microparticles Based on Resorbable Polyhydroxyalkanoates Loaded with Antibacterial and Cytostatic Drugs

Murueva,

Shershneva,

Shishatskaya

et al. 2023

IJMS

View full text Add to dashboard Cite

The development of controlled drug delivery systems, in the form of microparticles, is an important area of experimental pharmacology. The success of the design and the quality of the obtained microparticles are determined by the method of manufacture and the properties of the material used as a carrier. The goal is to obtain and characterize microparticles depending on their method of preparation, the chemical composition of the polymer and the load of the drugs. To obtain microparticles, four types of degradable PHAs, differing in their chemical compositions, degrees of crystallinity, molecular weights and temperature characteristics, were used (poly-3-hydroxybutyrate and copolymers 3-hydroxybutyric-co-3-hydroxyvaleric acid, 3-hydroxybutyric-co-4-hydroxybutyric acid, and 3-hydroxybutyric-co-3-hydroxyhexanoic acid). The characteristics of microparticles from PHAs were studied. Good-quality particles with an average particle diameter from 0.8 to 65.0 μm, having satisfactory ζ potential values (from −18 to −50 mV), were obtained. The drug loading content, encapsulation efficiency and in vitro release were characterized. Composite microparticles based on PHAs with additives of polyethylene glycol and polylactide-co-glycolide, and loaded with ceftriaxone and 5-fluorouracil, showed antibacterial and antitumor effects in E. coli and HeLa cultures. The results indicate the high potential of PHAs for the design of modern and efficient drug delivery systems.

show abstract

Section: Discussionmentioning

confidence: 99%