pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release

Ma, Bing; Li, Qing; Mi, Yingqi; Zhang, Jingjing; Tan, Wenqiang; Guo, Zhanyong

doi:10.1016/j.ijbiomac.2023.128590

Cited by 6 publications

(2 citation statements)

References 76 publications

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“…The absorbance was determined at 490 nm. The cell viability was calculated utilizing the following equation [67]:…”

Section: Cell Cytotoxicity Assaymentioning

confidence: 99%

Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels

Ma,

Li,

Zhang

et al. 2024

Marine Drugs

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The present study focused on the design and preparation of acid-responsive benzimidazole-chitosan quaternary ammonium salt (BIMIXHAC) nanogels for a controlled, slow-release of Doxorubicin HCl (DOX.HCl). The BIMIXHAC was crosslinked with sodium tripolyphosphate (TPP) using the ion crosslinking method. The method resulted in nanogels with low polydispersity index, small particle size, and positive zeta potential values, indicating the good stability of the nanogels. Compared to hydroxypropyl trimethyl ammonium chloride chitosan-Doxorubicin HCl-sodium tripolyphosphate (HACC-D-TPP) nanogel, the benzimidazole-chitosan quaternary ammonium salt-Doxorubicin HCl-sodium tripolyphosphate (BIMIXHAC-D-TPP) nanogel show higher drug encapsulation efficiency and loading capacity (BIMIXHAC-D-TPP 93.17 ± 0.27% and 31.17 ± 0.09%), with acid-responsive release profiles and accelerated release in vitro. The hydroxypropyl trimethyl ammonium chloride chitosan-sodium tripolyphosphate (HACC-TPP), and benzimidazole-chitosan quaternary ammonium salt-sodium tripolyphosphate (BIMIXHAC-TPP) nanogels demonstrated favorable antioxidant capability. The assay of cell viability, measured by the MTT assay, revealed that nanogels led to a significant reduction in the cell viability of two cancer cells: the human lung adenocarcinoma epithelial cell line (A549) and the human breast cancer cell line (MCF-7). Furthermore, the BIMIXHAC-D-TPP nanogel was 2.96 times less toxic than DOX.HCl to the mouse fibroblast cell line (L929). It was indicated that the BIMIXHAC-based nanogel with enhanced antioxidant and antitumor activities and acidic-responsive release could serve as a potential nanocarrier.

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“…The absorbance was determined at 490 nm. The cell viability was calculated utilizing the following equation [67]:…”

Section: Cell Cytotoxicity Assaymentioning

confidence: 99%

Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels

Ma,

Li,

Zhang

et al. 2024

Marine Drugs

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“…Nanoparticles, in particular, play a significant role in colon drug delivery by increasing drug residence time at the colonic site owing to their small size . Furthermore, nanomaterials are often recognized for their capability to neutralize free radicals, thereby aiding in scavenging ROS and RNS. , Nanogels represent one such formulation that holds promise for ROS quenching. − It is a nanosized drug delivery system exhibiting colloidal properties akin to submicrometer range hydrogel particles with similar internal structures. These hydrophilic, biocompatible nanogels boast excellent swelling properties, stability, and ease of modification .…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Kumawat,

Karmakar,

Ghoroi

2024

ACS Appl. Nano Mater.

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In the realm of colon-based drug delivery, developing a pHresponsive nanocarrier that exhibits significant intrinsic reactive oxygen species (ROS) scavenging activity holds great promise. To address this, a nanogel (NG) is synthesized using itaconic acid (IAc) and acrylamide (AAm) monomers in a molar ratio of 1:4 via free radical polymerization. The spherical NG of size 190 ± 15 nm is confirmed by using field emission scanning electron microscopy (FESEM). Dynamic light scattering (DLS) characterization reveals a hydrodynamic diameter and zeta potential of 271 ± 23 nm and −6.9 ± 2.3 mV, respectively. FTIR, XPS, and NMR analyses confirm the presence of multiple functionalities on the NG. Significant improvement in swelling (10 times) at colonic pH (pH 7.4) in contrast to gastric pH (pH 1.2) ensures the pH-responsive behavior of a NG along with five times higher ROS scavenging activity compared to control. As a model drug, doxorubicin (DOX) is employed to investigate release properties and cellular uptake. The NG exhibited drug loading capacity and efficiency of 26 ± 1.2% and 90 ± 1.3%, respectively, with a three times higher DOX release at pH 7.4 than at pH 1.2. Rheology data reveal the superior structural integrity of the doxorubicin loaded nanogel (DNG) compared to the NG. The biocompatibility of the NG is confirmed through MTT, the hemolysis assay, and cell uptake assays on HCT-116 colon cancer cells. The cellular uptake studies have indicated NG-mediated drug release in the colon microenvironment with subsequent passive diffusion of DOX into cells. These findings underscore the capability of the synthesized NG as a vehicle for oral drug delivery to the colon.

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Precise photothermal treatment of bacterial infection mediated by charge-switchable nanoplatform with acylsulfonamide betaine surface

Sun,

Hu,

et al. 2025

Colloids and Surfaces B: Biointerfaces

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pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release

Cited by 6 publications

References 76 publications

Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels

Improvement of the Antioxidant and Antitumor Activities of Benzimidazole-Chitosan Quaternary Ammonium Salt on Drug Delivery Nanogels

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Precise photothermal treatment of bacterial infection mediated by charge-switchable nanoplatform with acylsulfonamide betaine surface

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