Recently, polymerization-induced
self-assembly (PISA) has become
widely recognized as a robust and efficient route to produce block
copolymer nanoparticles of controlled size, morphology, and surface
chemistry. Several reviews of this field have been published since
2012, but a substantial number of new papers have been published in
the last three years. In this Perspective, we provide a critical appraisal
of the various advantages offered by this approach, while also pointing
out some of its current drawbacks. Promising future research directions
as well as remaining technical challenges and unresolved problems
are briefly highlighted.