pH-responsive polymer–drug conjugates: Design and progress

Pang, Xin; Jiang, Yue; Xiao, Qicai; Leung, Albert Wingnang; Hua, Heyu; Xu, Chuanshan

doi:10.1016/j.jconrel.2015.12.024

Cited by 279 publications

(159 citation statements)

References 108 publications

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“…For example, the drug release in many DDSs relies on spontaneous degradation of the nanocarriers in vivo and do not allow for controlled drug release, and drugs encapsulated in the DDS could not rapidly, completely be released in the tumor site. 2,6 Moreover, the traditional DDSs always suffer from unexpected drug release during circulation. 7 Although several nanoscale DDSs with controlled drug release ability exhibit great success such as pH-responsive, 8 GSH-responsive, 9 temperature-responsive, 10 and light-responsive [11][12][13][14][15] DDSs, another great challenge in oncology remains unresolved.…”

Section: Introductionmentioning

confidence: 99%

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A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

Shi¹,

Su²,

Liu³

et al. 2017

IJN

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Recently, stimuli-responsive drug delivery systems (DDSs) with high spatial/temporal resolution bring many benefits to cancer treatment. However, cancer cells always develop ways to resist and evade treatment, ultimately limit the treatment efficacy of the DDSs. Here, we introduce photo-activated nanoliposomes (PNLs) that impart light-induced cytotoxicity and reversal of drug resistance in synchrony with a photoinitiated and rapid release of antitumor drug. The PNLs consist of a nanoliposome doped with a photosensitizer (hematoporphyrin monomethyl ether [HMME]) in the lipid bilayer and an antitumor drug doxorubicin (DOX) encapsulated inside. PNLs have several distinctive capabilities: 1) carrying high loadings of DOX and HMME and releasing the payloads in a photo-cleavage manner with high spatial/temporal resolution at the site of actions via photocatalysis; 2) reducing drug efflux in MCF-7/multidrug resistance cells via decreasing the level of P-glycoprotein induced by photodynamic therapy (PDT); 3) accumulating in tumor site taking advantage of the enhanced permeability and retention effect; and 4) combining effective chemotherapy and PDT to exert much enhanced anticancer effect and achieving significant tumor regression in a drug-resistant tumor model with little side effects.

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Section: Introductionmentioning

confidence: 99%

“…a nanoliposome-based photoactivable DDs tumor models were generated by subcutaneous injection of 2×10 6 MCF-7/MDR cells in 0.1 mL saline into the right shoulder of nude mice. The mice were used when the tumor volume reached 60-100 mm 3 (~10 days after tumor inoculation).…”

mentioning

confidence: 99%

A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

Shi¹,

Su²,

Liu³

et al. 2017

IJN

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“…Polymer-drug prodrugs, which are obtained by covalent linkage of active drugs to water-soluble macromolecular carriers, have been investigated in a number of studies. [3][4][5] These prodrugs lead to the improvement of drug water solubility and chemical stability, 6 a much longer systemic circulation time or sustained release effect, 7 passive tumor targeting through an enhanced permeability and retention effect, 8 promotion of drug uptake into cells via endocytosis, 9 decreased toxicity, 10 better availability at the tumor site, and antimultidrug resistance. 11 Apart from introducing cell-targeting biomolecules for specific delivery, stimuli-responsive drug systems based on different internal environments in the human body can also enable controlled drug delivery and targeted therapeutics.…”

Section: Introductionmentioning

confidence: 99%

“…The red part is a hydrazone bond, which degrades under low pH conditions. 6 The green part is a 2,000 Da MPEG (methoxy polyethylene glycol) group, which is highly hydrophilic and which can greatly improve the water solubility of 10-HCPT by .3,000 times. 22 Owing to its high molecular weight, the conjugate circulates in the body for much longer than free 10-HCPT.…”

Section: Introductionmentioning

confidence: 99%

A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting

Liu¹,

Li²,

Guo³

et al. 2017

IJN

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“…A second technique consists of drug immobilization on the surface of polymeric nanocarriers through the engagement of covalent or non-covalent bonds [30,31]. The polymeric nanocarriers release the drug at the site of action by one of three general physicochemical mechanisms: (i) via swelling of the polymer nanoparticles by hydration, (ii) by an enzymatic reaction resulting in the cleavage of bonds and degradation of the polymer at the site of delivery and (iii) by de-adsorption of drugs from the swelled nanoparticles [32][33][34] (Figure 1). rials including magnetic nanoparticles, lipid-based and polymeric nanoparticles have been investigated as new treatments against pathogens in planktonic and biofilm form [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

Michalak¹,

Głuszek²,

Piktel³

et al. 2016

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The increased prevalence of antibiotic-resistant pathogens requires additional efforts to develop new antimicrobial agents and alternative methods to prevent and treat infections. In response to this challenge, a variety of nanotechnology-based tools are currently being designed and thoroughly investigated. To date, a considerable number of studies have reported increased activity of antibiotic-conjugated polymeric nanoparticles against bacteria and fungi associated with various infections, including those caused by drug-resistant pathogens. Importantly, high biocompatibility of these structures coupled with enhanced biological activity and improved pharmacokinetic properties supports the potential of these nanosystems as new tools to treat infections. In this review, we summarize the synthesis of polymer-based nanoparticles and describe their mechanism of action. We also highlight the recent advances in the application of antibiotic-conjugated polymeric nanoparticles as novel antimicrobial agents. StreszczenieStale narastająca lekooporność drobnoustrojów wymusza konieczność rozwoju alternatywnych metod profilaktyki i terapii zakażeń, a także uzasadnia prace nad nowymi lekami o aktywności przeciwdrobnoustrojowej. Realizacja tego celu jest moż-liwa dzięki zastosowaniu osiągnięć z zakresu nanotechnologii. Zwiększająca się liczba doniesień literaturowych potwierdza znaczną aktywność przeciwdrobnoustrojową nanocząstek polimerowych skoniugowanych z klasycznymi antybiotykami, co może zostać wykorzystane w terapii infekcji o charakterze bakteryjnym i grzybiczym, również tych wywoływanych przez patogeny lekooporne. Wysoka biokompatybilność nanocząstek polimerowych, a także możliwość zwiększania aktywności przeciwdrobnoustrojowej i poprawy parametrów farmakokinetycznych stosowanych obecnie chemioterapeutyków, wskazuje na możliwość zastosowania nanostruktur w nowoczesnej terapii chorób infekcyjnych. W niniejszej pracy podsumowano metody syntezy nanosystemów opartych na nanocząstkach polimerowych, a także opisano mechanizm ich działania. Przedstawione zostały również najnowsze osiągnięcia w syntezie nanocząstek skoniugowanych z antybiotykami, pozwalające na ich zastosowanie w terapii infekcji o charakterze bakteryjnym i grzybiczym.

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pH-responsive polymer–drug conjugates: Design and progress

Cited by 279 publications

References 108 publications

A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

A nanoliposome-based photoactivable drug delivery system for enhanced cancer therapy and overcoming treatment resistance

A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

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