pH-responsive polymeric micelles of poly(ethylene glycol)-b-poly(alkyl(meth)acrylate-co-methacrylic acid): Influence of the copolymer composition on self-assembling properties and release of candesartan cilexetil

Development and Characterization of Mixed Niosomes for Oral Delivery Using Candesartan Cilexetil as a Model Poorly Water-Soluble Drug

“…6(c)). This data is comparable with the literature findings (4,6,35). The later exothermic peaks demonstrated the decomposition of CC.…”

“…The characteristic peak of CC at 168°C was not present in the thermogram of lyophilized F9 niosome (Fig. 6(b)) demonstrating the incorporation of CC in niosomes and formation of its amorphous form after incorporation (6,35,37). The molecular distribution of amorphous CC in niosomes can explain this situation as stated by Dong and Feng (38).…”

Biorelevant dissolution of candesartan cilexetil

“…Besides, we suppose that the used media did not contain enzymes, which means SGF sp and SIF sp , due to other procedures mentioned in the paper. Our solubility data of CC measured by a shake-flask method in SGF sp and SIF sp do not correspond with data by Satturwar et al [20]. Our CC solubility in SGF sp is twice as high and CC solubility in SIF sp 13 times as low than Satturwar's data.…”

“…We observed that the powder of CC was almost dry after the tests because in the media without enzymes and surfactants the required wetting of the samples was not reached. Satturwar et al published the values of CC solubility in SGF (0.6 µg/ml) and SIF (8.6 µg/ml) [20]. However, the preparations of these media and the conditions of solubility study were not described in the research paper.…”

Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs

“…In vivo rat studies showed that the paclitaxel bioavailability of the PEG-PDENA-based system was 12.4%, a considerable improvement over the reported 6.5% bioavailability of the marketed Taxol ® formulation (Peltier et al 2006 ) . In an effort to increase the drug-release rate from polymeric micelle systems, block copolymers with ionizable groups have been studied (Sant et al 2004 ;Satturwar et al 2007 ;Kim et al 2008 ) . In these systems, a drug substance is solubilized in a hydrophobic core modifi ed with pH-sensitive moieties.…”