pH-responsive release system of isoniazid using palygorskite as a nanocarrier

Damasceno, Elmar; Almeida, Janiele Mayara Ferreira de; Silva, Isabel do Nascimento; Assis, Mikaely Lizandra Moreira de; Santos, Lamara Maciel dos; Dias, Elizete Faustino; Aragão, Victor Eduardo Bezerra; Veríssimo, Lourena Mafra; Fernandes, Nedja Suely; Silva, Djalma Ribeiro da

doi:10.1016/j.jddst.2019.101399

Cited by 19 publications

(33 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From the results obtained, we can infer that the higher the concentration of drug in solution, the greater the incorporated dose. Similar results were obtained in our previous work, in which we evaluated the adsorption of isoniazid in the palygorskite . According to de Almeida et al (2019), increasing the concentration of the drug in the medium can guarantee an increase in the number of molecules that are available to be adsorbed on the nanocarrier surfaces.…”

Section: Resultssupporting

confidence: 85%

“…The infrared spectra of palygorskite, rifampicin, and the PAL + RIF hybrid are shown in Figure . The FTIR spectrum for the palygorskite has been well described by Damasceno Junior et al (2020) . Through the spectrum obtained (Figure a), it was possible to identify the main characteristic bands of the clay mineral.…”

Section: Resultsmentioning

confidence: 64%

“…Therefore, we can infer that the drug molecules are coordinating with the superficial active sites of the palygorskite through, for example, hydrogen bonds. It was also possible to observe the appearance of bands characteristic of functional groups present in the structure of rifampicin, such as the occurrence of an absorption in 3400 cm –1 that corresponds to the axial deformation vibrations of N–H in secondary amines. ,, …”

Section: Resultsmentioning

confidence: 99%

“…PAL was used in its natural form, without any previous chemical treatment. However, to remove possible aggregates of quartz that may be present in the sample, the material underwent a pretreatment, as described by Damasceno Junior et al (2020) . Briefly, the mineral clay was dispersed in distilled water, to obtain a 1:10 dispersion (PAL/water).…”

Section: Materials and Methodsmentioning

confidence: 99%

“…The in vitro release studies were conducted according to the methodology used in a previous study . This methodology was based on the work of Oliveira, Alcântara, and Pergher (2017) and de Almeida et al (2019) .…”

Section: Materials and Methodsmentioning

confidence: 99%

See 4 more Smart Citations

Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug

et al. 2020

Self Cite

View full text Add to dashboard Cite

Despite having good efficacy in the treatment and prevention of tuberculosis, the administration of rifampicin (RIF) can cause serious side effects, resulting from the prolonged use of this substance. Thus, it is necessary to seek new systems for administering tuberculostatic drugs, to avoid unwanted adverse effects, increase their bioavailability and, consequently, improve their therapeutic efficacy. The present work describes the achievement of a pH-responsive system for RIF, using palygorskite, a fibrous clay mineral, as a nanocarrier. To evaluate the influence of some operational variables on the drug adsorption process, a 2 4 factorial experimental design was used. The experiment using a maximum concentration (0.125 mg/mL), lower mass of PAL (300 mg), and lower pH (pH 2) was more efficient compared to other experiments, resulting in a higher dose of the incorporated drug, equivalent to 33.62 mg/g. To elucidate the mechanism of interaction between the materials, the hybrid obtained was characterized by different characterization techniques (Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetry/derived thermogravimetry, zeta potential, scanning electron microscopy, and dispersive energy spectroscopy). In addition, kinetic models and adsorption isotherms were applied to the experimental data. Through in vitro release studies, it was possible to verify the effectiveness of the pH-dependent system obtained. The adjustment of experimental release data to the theoretical model of Higuchi indicated that the release of rifampicin occurs in a prolonged way from the palygorskite.

show abstract

Section: Resultssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 99%

Section: Materials and Methodsmentioning

confidence: 99%

Section: Materials and Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Photocatalytic degradation of Novacron blue and Novacron yellow textile dyes by the TiO2/palygorskite nanocomposite

Assis

Damasceno

Almeida

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

Montmorillonite as an Anti-Tuberculosis Rifampicin Drug Carrier: DFT and Experimental Study

Scholtzová

Jankovič

Tunega

2023

Clays and clay miner.

View full text Add to dashboard Cite

A hybrid of montmorillonite (Mnt) and rifampicin (RIF) was synthesized and the structure and stability of the drug carrier system clarified. Density functional theory calculations involving dispersion corrections (DFT-D3) were performed to characterize interactions acting in the interlayer space of montmorillonite intercalated with rifampicin. The structure and stability of the RIF-Mnt intercalated complex were determined. Calculations revealed the deformation of the molecular structure of rifampicin after intercalation into the Mnt interlayer space due to the clay environment. The ansa chain of RIF was bent in the interlayer space compared with the structure of the RIF molecule in the monocrystal. RIF was keyed into the Mnt surface by means of numerous hydrogen bonds of weak to moderate strength. The calculated vibrational spectrum from ab initio molecular dynamics (AIMD) was in good agreement with the FTIR measured spectra and helped to analyze the overlapped vibrational bands. Based on analysis of structural stability, theoretical calculations revealed that Mnt is a suitable drug carrier for delayed release of the RIF drug. Batch adsorption experiments showed the large adsorption capacity of montmorillonite for RIF.

show abstract

pH-responsive release system of isoniazid using palygorskite as a nanocarrier

Cited by 19 publications

References 44 publications

Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug

Obtaining and Applying Nanohybrid Palygorskite-Rifampicin in the pH-Responsive Release of the Tuberculostatic Drug

Photocatalytic degradation of Novacron blue and Novacron yellow textile dyes by the TiO2/palygorskite nanocomposite

Montmorillonite as an Anti-Tuberculosis Rifampicin Drug Carrier: DFT and Experimental Study

Contact Info

Product

Resources

About