pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery

Sun, Henglai; Li, Xinyu; Liu, Qian; Sheng, Huagang; Zhu, Liqiao

doi:10.1080/1061186x.2024.2349124

Journal of Drug Targeting

2024

DOI: 10.1080/1061186x.2024.2349124

|View full text |Cite

pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery

Henglai Sun,

Xinyu Li,

Qian Liu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

References 305 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Nanomedicine for cancer patient‐centered care

Sorrentino,

Ciummo,

Fieni

et al. 2024

MedComm

View full text Add to dashboard Cite

Cancer is a leading cause of morbidity and mortality worldwide, and an increase in incidence is estimated in the next future, due to population aging, which requires the development of highly tolerable and low‐toxicity cancer treatment strategies. The use of nanotechnology to tailor treatments according to the genetic and immunophenotypic characteristics of a patient's tumor, and to allow its targeted release, can meet this need, improving the efficacy of treatment and minimizing side effects. Nanomedicine‐based approach for the diagnosis and treatment of cancer is a rapidly evolving field. Several nanoformulations are currently in clinical trials, and some have been approved and marketed. However, their large‐scale production and use are still hindered by an in‐depth debate involving ethics, intellectual property, safety and health concerns, technical issues, and costs. Here, we survey the key approaches, with specific reference to organ‐on chip technology, and cutting‐edge tools, such as CRISPR/Cas9 genome editing, through which nanosystems can meet the needs for personalized diagnostics and therapy in cancer patients. An update is provided on the nanopharmaceuticals approved and marketed for cancer therapy and those currently undergoing clinical trials. Finally, we discuss the emerging avenues in the field and the challenges to be overcome for the transfer of nano‐based precision oncology into clinical daily life.

show abstract

Nanomedicine for cancer patient‐centered care

Sorrentino,

Ciummo,

Fieni

et al. 2024

MedComm

View full text Add to dashboard Cite

show abstract

Nanogels in Biomedical Engineering: Revolutionizing Drug Delivery, Tissue Engineering, and Bioimaging

Dehchani,

Jafari,

Shahi

2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

Nanogels represent a significant innovation in the fields of nanotechnology and biomedical engineering, combining the properties of hydrogels and nanoparticles to create versatile platforms for drug delivery, tissue engineering, bioimaging, and other biomedical applications. These nanoscale hydrogels, typically ranging from 10 to 1000 nm, possess unique characteristics such as high water content, biocompatibility, and the ability to encapsulate both hydrophilic and hydrophobic molecules. The review explores the synthesis, structural configurations, and stimuli‐responsive nature of nanogels, highlighting their adaptability for targeted drug delivery, including across challenging barriers like the blood–brain barrier. Furthermore, the paper delves into the biomedical applications of nanogels, particularly in drug delivery systems, tissue engineering, and bioimaging, demonstrating their potential to revolutionize these fields. Despite the promising preclinical results, challenges remain in translating these technologies into clinical practice, including issues related to stability, scalability, and regulatory approval. The review concludes by discussing future perspectives, emphasizing the need for further research to optimize the properties and applications of nanogels, ultimately aiming to enhance their efficacy and safety in clinical settings.

show abstract

Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors

Wu,

Chen,

Wang

et al. 2024

Chemical Engineering Journal

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery

Cited by 6 publications

References 305 publications

Nanomedicine for cancer patient‐centered care

Nanomedicine for cancer patient‐centered care

Nanogels in Biomedical Engineering: Revolutionizing Drug Delivery, Tissue Engineering, and Bioimaging

Nanoparticle‐Based drug delivery strategies for targeted therapy to hypoxic solid tumors

Contact Info

Product

Resources

About