pH-Responsive sulphonated mesoporous silica: a comparative drug release study

Abstract

Control of morphology and surface functionalization of mesoporous silica materials have enhanced the biocompatibility of these materials with high surface areas and total pore volumes. The functionalization of mesoporous silica materials with organic moieties exhibited controlled release and molecular recognition capabilities for drug delivery. Design of functional mesoporous silica with various mechanisms of controlled release and introduction of new characteristics is very interesting for the construction of highly selective drug carrier. Loading of procaine hydrochloride drug (PrHy) into functionalized KIT-6-SO 3 H and SBA-15-SO 3 H was investigated by a quartz crystal microbalance (QCM) technique and UV-visible spectroscopy. The release was carefully studied by systematically tuning the pH media at simulating gastric fluid without pepsin (SGF, pH 2) and simulating intestinal fluid without pancreatin (SIF, pH 7.4), as well.

Study on catalytic efficiency of platinum and silver nanoparticles confined in nanosized channels of a 3-D mesostructured silica

“…2B). Before deposition of metal NPs, NH 2 -KIT-6 shows a well-resolved diffraction peak at 2θ = 22° indexed as (211), indicating the formation of a mesostructural ordering with a Ia3d symmetry of the bcc space group similar to those of previously reported for KIT-6 materials [65,66,[69][70][71]. After deposition of Pt NPs (Fig.…”

“…Mesoporous silica KIT-6 was synthesized via sol-gel method as reported earlier [65,66]. Separately, 6.0 g of Pluronic ® P123 was dissolved in 220 mL deionized water and 12.0 g of concentrated HCl (35%) in 250 mL round-bottom flask.…”

Advanced Nanoporous Material–Based QCM Devices: A New Horizon of Interfacial Mass Sensing Technology

“…In the similar way, KIT-6 and SBA-15 were functionalized with sulfonated group (SO 3 H-KIT-6 and -SBA-15) and used for investigating the loading of procaine hydrochloride (PrHCl) drug. [72] As a local anesthetic drug, PrHCl was loaded in ordered mesoporous silica to design a controlled DDS system that can be employed for relieving the pain of the general intramuscular injection in general of This article is protected by copyright. All rights reserved.…”

Synthesis of nanoporous calcium carbonate spheres using double hydrophilic block copolymer poly(acrylic acid-b-N-isopropylacrylamide)

“…Here the release kinetic process was studied using first order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas models. 16 First order:…”