pH-responsive surface charge reversal carboxymethyl chitosan-based drug delivery system for pH and reduction dual-responsive triggered DOX release

Xie, Pengwei; Liu, Peng

doi:10.1016/j.carbpol.2020.116093

Cited by 70 publications

(24 citation statements)

References 35 publications

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“…At present, the commonly used charge-reversal materials are carboxymethyl chitosan [110] , polyurethane [111] , amino acid polymer [112 , 113] , etc. The isoelectric point of such substances is between the pH of normal physiological environment and the tumor microenvironment (pH 6.5–6.8).…”

Section: Surface Chargementioning

confidence: 99%

Size, shape, charge and “stealthy” surface: Carrier properties affect the drug circulation time in vivo

Di¹,

Gao²,

Du³

et al. 2021

Asian Journal of Pharmaceutical Sciences

167

104

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The present review sets out to discuss recent developments of the effects and mechanisms of carrier properties on their circulation time. For most drugs, sufficient in vivo circulation time is the basis of high bioavailability. Drug carrier plays an irreplaceable role in helping drug avoid being quickly recognized and cleared by mononuclear phagocyte system, to give drug enough time to arrive at targeted organ and tissue to play its therapeutic effect. The physical and chemical properties of drug carriers, such as size, shape, surface charge and surface modification, would affect their in vivo circulation time, metabolic behavior and biodistribution. The final circulation time of carriers is determined by the balance between macrophage recognitions, blood vessel penetration and urine excretion. Therefore, when designing the drug delivery system, we should pay much attention to the properties of drug carriers to get enough in vivo circulation time to arrive at target site eventually. This article mainly reviews the effect of carrier size, size, surface charge and surface properties on its circulation time in vivo , and discusses the mechanism of these properties affecting circulation time. This review has reference significance for the research of long-circulation drug delivery system.

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Section: Surface Chargementioning

confidence: 99%

Size, shape, charge and “stealthy” surface: Carrier properties affect the drug circulation time in vivo

Di¹,

Gao²,

Du³

et al. 2021

Asian Journal of Pharmaceutical Sciences

167

104

View full text Add to dashboard Cite

show abstract

“…Cationic polymers are polymers bearing the positive charge or incorporating cations in the structure. Some cationic polymers, especially the cationic centers of which are imidazole groups or amino esters, can be deprotonated at basic/neutral pH, whereas become protonated and hydrophilic under acidic condition [ 60 – 62 ]. For example, owing to the ampholytic nature, carboxymethyl chitosan (CMCS) displayed negative charge at near-neutral media due to the deprotonation of amine and carboxyl groups, the negatively charged carboxymethyl chitosan could reduce plasma protein binding thus to prolong blood circulation time and improve tumor accumulation of nanoparticles.…”

Section: Mechanisms Of Triggered Surface Charge Conversionmentioning

confidence: 99%

Charge reversal nano-systems for tumor therapy

Zhang

Chen

et al. 2022

J Nanobiotechnol

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Surface charge of biological and medical nanocarriers has been demonstrated to play an important role in cellular uptake. Owing to the unique physicochemical properties, charge-reversal delivery strategy has rapidly developed as a promising approach for drug delivery application, especially for cancer treatment. Charge-reversal nanocarriers are neutral/negatively charged at physiological conditions while could be triggered to positively charged by specific stimuli (i.e., pH, redox, ROS, enzyme, light or temperature) to achieve the prolonged blood circulation and enhanced tumor cellular uptake, thus to potentiate the antitumor effects of delivered therapeutic agents. In this review, we comprehensively summarized the recent advances of charge-reversal nanocarriers, including: (i) the effect of surface charge on cellular uptake; (ii) charge-conversion mechanisms responding to several specific stimuli; (iii) relation between the chemical structure and charge reversal activity; and (iv) polymeric materials that are commonly applied in the charge-reversal delivery systems. Graphical Abstract

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“…Moreover, by adjusting the release response mechanism and release rate of drugs under different stimuli, the nanocarriers can control the sequence and time schedule of drug combination therapy, so as to achieve more accurate drug delivery process and improve the effect and specificity of combined action . The drug release behavior can be realized in different stimulant responses in tumor therapy, such as pH (Wang et al, 2017), hypoxia (Kumari et al, 2020), reduction (Xie and Liu, 2020), enzyme (Shan et al, 2019), temperature (Jommanee et al, 2018), ultrasound (Xia et al, 2018), etc.…”

Section: Taking Advantage Of Analogs Of Celastrolmentioning

confidence: 99%

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Shi

et al. 2020

Front. Pharmacol.

117

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Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits significant broad-spectrum anticancer activities for the treatment of a variety of cancers including liver cancer, breast cancer, prostate tumor, multiple myeloma, glioma, etc. However, the poor water stability, low bioavailability, narrow therapeutic window, and undesired side effects greatly limit its clinical application. To address this issue, some strategies were employed to improve the anticancer efficacy and reduce the side-effects of celastrol. The present review comprehensively focuses on the various challenges associated with the anticancer efficiency and drug delivery of celastrol, and the useful approaches including combination therapy, structural derivatives and nano/micro-systems development. The specific advantages for the use of celastrol mediated by these strategies are presented. Moreover, the challenges and future research directions are also discussed. Based on this review, it would provide a reference to develop a natural anticancer compound for cancer treatment.

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pH-responsive surface charge reversal carboxymethyl chitosan-based drug delivery system for pH and reduction dual-responsive triggered DOX release

Cited by 70 publications

References 35 publications

Size, shape, charge and “stealthy” surface: Carrier properties affect the drug circulation time in vivo

Size, shape, charge and “stealthy” surface: Carrier properties affect the drug circulation time in vivo

Charge reversal nano-systems for tumor therapy

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

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