pH-Responsive Water-Soluble Cyclic Polymer

Miao, Zhihui; Kubo, Tomohiro; Pal, Digvijayee; Sumerlin, Brent S.; Veige, Adam S.

doi:10.1021/acs.macromol.9b01307

Cited by 49 publications

(43 citation statements)

References 62 publications

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“…A similar result was recently reported by Veige et al , who demonstrated that linear and cyclic polyphenols display nearly the same value of p K a when dissolved in aqueous media.…”

Section: Resultssupporting

confidence: 89%

“…Interestingly, a very similar, general trend was observed for the two different polymer topologies, for which a comparable pK a value between 6 and 6.5 was identified. 52,53 A similar result was recently reported by Veige et al, 54 who demonstrated that linear and cyclic polyphenols display nearly the same value of pK a when dissolved in aqueous media.…”

Section: Resultssupporting

confidence: 84%

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Functional Nanoassemblies of Cyclic Polymers Show Amplified Responsiveness and Enhanced Protein-Binding Ability

et al. 2020

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The physicochemical properties of cyclic polymer adsorbates are significantly influenced by the steric and conformational constraints introduced during their cyclization. These translate into a marked difference in interfacial properties between cyclic polymers and their linear counterparts when they are grafted onto surfaces yielding nanoassemblies or polymer brushes. This difference is particularly clear in the case of cyclic polymer brushes that are designed to chemically interact with the surrounding environment, for instance, by associating with biological components present in the medium, or, alternatively, through a response to a chemical stimulus by a significant change in their properties. The intrinsic architecture characterizing cyclic poly(2-oxazoline)-based polyacid brushes leads to a broad variation in swelling and nanomechanical properties in response to pH change, in comparison with their linear analogues of identical composition and molecular weight. In addition, cyclic glycopolymer brushes derived from polyacids reveal an enhanced exposure of galactose units at the surface, due to their expanded topology, and thus display an increased lectin-binding ability with respect to their linear counterparts. This combination of amplified responsiveness and augmented protein-binding capacity renders cyclic brushes invaluable building blocks for the design of "smart" materials and functional biointerfaces.

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“…A similar result was recently reported by Veige et al , who demonstrated that linear and cyclic polyphenols display nearly the same value of p K a when dissolved in aqueous media.…”

Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 84%

Functional Nanoassemblies of Cyclic Polymers Show Amplified Responsiveness and Enhanced Protein-Binding Ability

et al. 2020

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“…Stimulus responsive polymers , have recently attracted more and more interest. They are able to respond to various stimuli like temperature, , pH, − stress, , voltage, − and light. − Because the temperature can be easily controlled, thermoresponsive polymers are extensively studied. An aqueous thermoresponsive polymer solution presents an abrupt change of transmittance from transparent to turbid once the external temperature is above the transition temperature (TT). , This change is caused by the changed interactions between hydrophilic and hydrophobic groups in the polymer with the surrounding water upon heating.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Stain Removal Achieved by Controlling the Fractions of Light and Thermo Responsive Components in the Dual-Responsive Copolymer Immobilized on Cotton Fabrics by Cross-Linker

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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Enhanced synergistic stain removal is realized by tailoring the comonomer fractions of a light- and thermo-dual responsive copolymer, which is immobilized on cotton fabrics by a cross-linker. The copolymer poly(acrylamide azobenzene-co-ethylene glycol methacrylate-co-triethylene glycol methyl ether methacrylate), denoted P(AAAB1-co-EGMA2-co-MEO3MA17), is prepared by the ATRP polymerization method. The present molar ratio for these monomers is 1:2:17. Because of the existence of the light-responsive AAAB unit, the transition temperature of its aqueous solution under UV radiation is shifted to 39 °C, which is 2 °C higher than that in ambient conditions. This increase is caused by the trans–cis isomerization from the azobenzene groups, indicating an increased hydrophilicity of P(AAAB1-co-EGMA2-co-MEO3MA17) under UV radiation. After being immobilized onto cotton fabrics by a cross-linker, they are also dual-responsive. The equilibrium swelling ratio (ESR) of the cotton fabrics is further increased after UV radiation. Compared to our former investigation, the reduction of the AAAB molar fraction from 0.1 to 0.05 causes an increase of the ESR value by 10%. Moreover, the stain removal efficiency of the cotton fabrics immobilized with P(AAAB1-co-EGMA2-co-MEO3MA17) by cross-linker is also significantly improved under UV radiation. The hydrophilicity of the copolymer mainly from the MEO3MA units is crucial to the cleaning capability. Additionally lowering the attachment between stain and the copolymer coating on the cotton fabrics by trans–cis isomerization in those AAAB units also favors the cleaning. Hence, the stain removal is strongly improved by optimizing the fraction of light- versus thermo-responsive components in the copolymer, which can profoundly reduce the consumption of chemical detergents and energy during laundry.

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“…Stimuli-responsive polymers − have attracted significant attention because of their variation with the changes of physical and/or chemical properties by the introduction of various important stimuli, such as temperature, − pH, − light, − and glucose. − The implication of such a responsive polymer mostly relies on the controlled drug delivery application . However, their involvement in sensing applications is still in a premature state.…”

Section: Introductionmentioning

confidence: 99%

Two-in-One Dual-Channel Boronic Ester Block Copolymer for the Colorimetric Detection of Cysteine and Glucose at Neutral pH

Sharma

Haldar

Lee

2021

ACS Sustainable Chem. Eng.

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Developing a chemosensor to recognize more than one biologically important molecule from a single polymeric entity is essential. In this study, a block copolymer probe [PPBA-b-PDMA (P1)] of (2-phenylboronic esters-1,3-dioxane-5-ethyl) methyl acrylate (PBA) and N,N′-dimethylacrylamide (DMA) was synthesized by reversible addition−fragmentation chain transfer polymerization using a cysteine-detectable aldehydefunctionalized azobenzene chain transfer agent. P1 was selfassembled in water to form micelles at neutral pH. The colorimetric detection was not observed upon adding cysteine to the micellar solution since water-soluble cysteine could not reach the aldehyde group of the azo receptor hidden in the micelles' center. However, with the introduction of glucose, micelles became swollen since the PPBA block changed its behavior to hydrophilic by transforming a boronic ester to boronic acid. Thus, the azo receptor became exposed to cysteine, leading to the colorimetric detection of cysteine. Glucose detection was also demonstrated by titrating P1 solution with glucose at a fixed amount of cysteine. Therefore, a unique platform with a dual-detection capacity of cysteine and glucose is proposed.

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pH-Responsive Water-Soluble Cyclic Polymer

Cited by 49 publications

References 62 publications

Functional Nanoassemblies of Cyclic Polymers Show Amplified Responsiveness and Enhanced Protein-Binding Ability

Functional Nanoassemblies of Cyclic Polymers Show Amplified Responsiveness and Enhanced Protein-Binding Ability

Synergistic Stain Removal Achieved by Controlling the Fractions of Light and Thermo Responsive Components in the Dual-Responsive Copolymer Immobilized on Cotton Fabrics by Cross-Linker

Two-in-One Dual-Channel Boronic Ester Block Copolymer for the Colorimetric Detection of Cysteine and Glucose at Neutral pH

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