pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging

Wang, Zhimin; Upputuri, Paul Kumar; Zhen, Xu; Zhang, Ruochong; Jiang, Yuyan; Ai, Xiangzhao; Zhang, Zhijun; Hu, Ming; Meng, Zhenyu; Lu, Yunpeng; Zheng, Yuanzhou; Pu, Kanyi; Pramanik, Manojit; Xing, Bengang

doi:10.1007/s12274-018-2175-9

Cited by 83 publications

(83 citation statements)

References 52 publications

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“…The oxidation product of TMB could form charge transfer complex with TMB and display a characteristic absorbance at 652 nm ( Fig. 1f) 34 . The oxidaselike activity of PtCo@G was further characterized with several different oxidase substrates, such as 2, 2′azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and o-phenylenediamine (OPD).…”

Section: Resultsmentioning

confidence: 99%

In vivo activation of pH-responsive oxidase-like graphitic-nanozymes for selective killing of Helicobacter pylori

Zhang

Deng

et al. 2020

Preprint

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Helicobacter pylori infection is a major etiological factor in various gastric diseases. However, clinical antibiotic triple therapy for H. pylori often encounters such critical problems as continuously decreased therapeutic efficacy and symbiotic bacteria experiencing severe side effects. Herein, we developed an in vivo activatable pH-responsive graphitic nanozyme, PtCo@Graphene (PtCo@G), for the selective treatment of H. pylori infections. Such nanozymes can resist gastric acid corrosion and activate oxidase-like activity to stably generate reactive oxygen species only in the acidic gastric milieu which endows them with superior selective bactericidal property. C18-PEGn-Benzeneboronic acid molecules were further modified on the PtCo@G, improving its targeting capability to H. pylori. Under acidic gastric pH, graphitic nanozymes showed notable bactericidal activity toward H. pylori, while no bacterial killing was observed under the intestinal condition. In the H. pylori-infected mouse model, high antibacterial capability toward H. pylori and negligible side effects toward normal tissues and symbiotic bacteria were also achieved. This graphitic nanozyme performs the desired enzyme-like activity at corresponding physiological sites and may address critical issues in the clinical treatment of H. pylori infections.

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Section: Resultsmentioning

confidence: 99%

In vivo activation of pH-responsive oxidase-like graphitic-nanozymes for selective killing of Helicobacter pylori

Zhang

Deng

et al. 2020

Preprint

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“…These fluorescent biodegradation products were tracked, revealing that SPN4‐6 were excreted out of mice through urine and feces within 15 days after systematic administration (Figure e,f). In another study, Xing and co‐workers reported a charge‐transfer nanocomplex (CTN) with a pH related PA signal and used it for NIR‐II PA imaging . As the increment of pH, diimine was produced as the product, leading to the disassembly of complex and the decrease of PA signals.…”

Section: Nir‐ii Pa Imagingmentioning

confidence: 99%

Second Near‐Infrared Absorbing Agents for Photoacoustic Imaging and Photothermal Therapy

2019

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Photoacoustic (PA) imaging and photothermal therapy (PTT) provide useful tools for diagnosis and treatments of diseases. However, current applications of PA imaging and PTT are greatly limited by their relying on light source in the first near‐infrared (NIR) window (NIR‐I, 750–1000 nm), which shows shallow tissue penetration depth. Recently, this predicament is addressed by the use of second NIR (NIR‐II) light ranging from 1000 to 1700 nm due to reduced light–tissue interaction and increased allowable power density for light irradiation. Since a few endogenous biomolecules can absorb or emit NIR‐II light, it is necessary to develop contrast and therapeutic agents used for PA imaging and PTT in the NIR‐II window. This review summarizes the recent progresses of NIR‐II absorbing optical agents for PA imaging and PTT in living animal models. The prominent performance of NIR‐II PA imaging and NIR‐II PTT is first introduced with the use of optical agents, followed by discussion of the applications of NIR‐II PTT under the guidance of NIR‐I or NIR‐II PA imaging. At last, challenges and perspectives of NIR‐II absorbing optical agents for PA imaging and PTT are proposed.

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“…Compared to the images of the tumor without TSPNs, the signal was enhanced ∼7.0-fold at 1100 nm and ∼13.3-fold at 1300 nm. Reports on NIR-II tumor imaging 116,154 promised that it can provide high sensitivity and depth for tumor imaging compared to NIR-I window.…”

Section: Skin and Tumor Imagingmentioning

confidence: 99%

“…[110][111][112][113][114][115] The PA signal generated by NIR-II wavelengths is weak and hence effective contrast agents are often necessary for enhancing the image contrast. With the increasing demonstrations on the advantages of PAI, efforts are made to develop strong NIR-II absorbing organic, 37,[116][117][118] inorganic, [119][120][121][122][123][124][125][126] etc. Although, these nanoparticles show broad absorption spectrum in the NIR-II window, most of them are demonstrated for PAI at 1064-nm wavelength because 1064-nm nanosecond laser (Nd:YAG laser) is commercially available.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic imaging in the second near-infrared window: a review

2019

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Photoacoustic (PA) imaging is an emerging medical imaging modality that combines optical excitation and ultrasound detection. Because ultrasound scatters much less than light in biological tissues, PA generates high-resolution images at centimeters depth. In recent years, wavelengths in the second near-infrared (NIR-II) window (1000 to 1700 nm) have been increasingly explored due to its potential for preclinical and clinical applications. In contrast to the conventional PA imaging in the visible (400 to 700 nm) and the first NIR-I (700 to 1000 nm) window, PA imaging in the NIR-II window offers numerous advantages, including high spatial resolution, deeper penetration depth, reduced optical absorption, and tissue scattering. Moreover, the second window allows a fivefold higher light excitation energy density compared to the visible window for enhancing the imaging depth significantly. We highlight the importance of the second window for PA imaging and discuss the various NIR-II PA imaging systems and contrast agents with strong absorption in the NIR-II spectral region. Numerous applications of NIR-II PA imaging, including whole-body animal imaging and human imaging, are also discussed.

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pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging

Abstract: pH-sensitive and biodegradable charge-transfer nanocomplex for second near-infrared photoacoustic tumor imaging

Cited by 83 publications

References 52 publications

In vivo activation of pH-responsive oxidase-like graphitic-nanozymes for selective killing of Helicobacter pylori

In vivo activation of pH-responsive oxidase-like graphitic-nanozymes for selective killing of Helicobacter pylori

Second Near‐Infrared Absorbing Agents for Photoacoustic Imaging and Photothermal Therapy

Photoacoustic imaging in the second near-infrared window: a review

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