pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride

Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy

“…161 Unlike most of the reported anionic polymer/DOXÁHCl complexes, 162 which were based on non-biodegradable polymers (e.g., poly 163 (methacrylic acid) and poly(acrylic acid)) and devoid of in vivo 164 studies [33,34], the design of the present system is based on bio-165 compatible and biodegradable PEG-PAA. Compared with other bio-166 degradable polymers (e.g., c-polyglutamic acid and poly(ethylene 167 glycol)-b-poly(L-glutamic acid) [27,32], hydrophobic groups were 168 introduced into the copolymers to enhance the construct stability 169 of the nanoparticles towards dissociation by a simple copolymeri-170 zation procedure of c-benzyl-L-glutamate-N-carboxyanhydride 171 (BLG-NCA) and Phe-NCA monomers.…”

“…The three domains displayed distinct functions: PEG block chain 33 for prolonged circulation; poly(phenylalanine) domain for stabilizing the nanoparticle construct through 34 hydrophobic/aromatic interactions; and the poly(glutamic acid) domain for providing electrostatic inter- 35 actions with the cationic drug to be loaded. The copolymer could self-assemble into micellar-type nano- 36 particles, and DOX was successfully loaded into the interior of nanoparticles by simple mixing of DOXÁHCl 37 and the copolymer in the aqueous phase.…”

Design and evaluation of pH-sensitive liposomes constructed by poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate for doxorubicin delivery

“…The antitumor properties of DOX were used to investigate the inhibitory effect of liposomes on tumor cells. Furthermore, the in vitro release in response to virous pH, cellular uptake, and cell behavior inside liposomes was investigated by the fluorescence signal intensity of DOX [25,26].…”

Polimerossomos versus lipossomos: a evolução da "Bala Mágica"

“…66 Resultados de DLS podem sugerir agregação dos sistemas ou indicar mudanças nos tamanhos dos sistemas mediante alterações de condições experimentais. 67,68 (3) em que: D f é o coeficiente de difusão, k B é a constant de Boltzmann (1,38064852 × 10 −23 J/K), T a temperatura, η a viscosidade do solvente e R h é o raio hidrodinâmico.…”