pH-sensitive KHA/CMC-Fe3+@CS hydrogel loading and the drug release properties of riboflavin

Song, Jié; Li, Xi; Niu, Yuhua; Chen, Lijun; Wei, Zhiqiang; Li, Yidan; Wang, Youqian

doi:10.1016/j.partic.2023.04.003

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…As the pH increases to 6.8 and 7.4, the increasing deprotonation of SALG with pH causes the disintegration of the hydrogel via stretching of the SALG chains releasing its free surface as a result of the repulsion force between COO À anions. At pH 7.4, the higher concentration of COO À anions within the hydrogel compared to that at pH 6.8 further swells the structure because of the increased repulsion force between the anions and the water absorption capacity, 74 which leads to a cumulative AMX release of ca. 74% at 25 h. AMX is cationic at pH 1.2 and interacts strongly with SALG; at pH 6.8 as a zwitterion, the interaction forces reduce due to the negative surface charges; and it is anionic at pH 7.4, resulting in the disruption of electrostatic interaction.…”

Section: Biodegradationmentioning

confidence: 99%

Fabrication of pH‐sensitive double cross‐linked sodium alginate/chitosan hydrogels for controlled release of amoxicillin

Feyissa

Gupta

Edossa

et al. 2023

Polymer Engineering & Sci

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This research aims to fabricate a potent pH‐sensitive double network sodium alginate/chitosan hydrogel cross‐linked by calcium chloride (CaCl2) and glutaraldehyde for the controlled release of amoxicillin (AMX) to mitigate gastrointestinal tract bacterial infection. The effect of polymer ratios and CaCl2 concentration is investigated by the developing porosity, gel fraction, and swelling ratios in simulated physiological fluids of different pH and in vitro biodegradation at pH 7.4. Interaction between the polymers with the formation of cross‐linked structures, amorphous phase nature, good thermal stability, and transition from porous, fibrous structures to highly densified structures of the hydrogels is revealed by scanning electron microscopy, Fourier‐transform infrared spectroscopy, x‐ray diffraction, and thermogravimetric analysis. Based on structure–property relationships, a sodium alginate/chitosan hydrogel (weight ratio 75:25) cross‐linked with 2% CaCl2 and soaked in 2% (25 wt/v% solutions) glutaraldehyde is chosen for the incorporation of 200 mg of the drug. The percent cumulative AMX release in physiological fluids and the drug release kinetics using different models reveal that the most appropriate Korsmeyer–Peppas model suggests AMX release from the matrix follows diffusion coupled with swelling‐regulated time‐dependent non‐Fickian transport process related to hydrogel erosion. Excellent antibacterial against Streptococcus pyogenes and Escherichia coli is exhibited by this composition.

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Section: Biodegradationmentioning

confidence: 99%