pH-sensitive release of antioxidant Se-glycoconjugates through a flexible polymeric patch

Serpico, Luigia; Iacono, Stefania Dello; Stefano, Luca De; Martino, Selene De; Battisti, Mario; Dardano, Principia; Pedatella, Silvana; Nisco, Mauro De

doi:10.1016/j.eurpolymj.2022.111486

Cited by 7 publications

(4 citation statements)

References 56 publications

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“…The search for innovative approaches to enhance the wound healing process leveraging the well-established regenerative properties of HCAs and novel Se-sugars was the driving force in exploring the effects of the synthesized compounds on HaCaT cell line [ 34 ]. Indeed, keratinocytes play a central role in the repair of cutaneous injuries [ 35 ], as they form the outer layer of the skin and serve a crucial function in the reconstruction of damaged tissues [ 36 ] through cell proliferation and migration, and the production of growth factors [ 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

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Innovative Cosmeceutical Ingredients: Harnessing Selenosugar-Linked Hydroxycinnamic Acids for Antioxidant and Wound-Healing Properties

Cimmino,

De Nisco,

Piccolella

et al. 2024

Antioxidants

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Selenosugars are gaining growing interest due to their antioxidant efficacy, and their ability to inhibit glycosidases, repair skin tissue or reduce endothelial dysfunction. Among selenosugars, those in which selenium replaces heterocyclic oxygen in a 5-membered sugar were our focus, and their coupling with phenolic compounds appears to be a strategy aimed at producing new compounds with enhanced antioxidant efficacy. In this context, the Mitsunobu reaction has been advantageously explored to obtain trans-p-coumaroyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose, trans-caffeoyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose, and trans-feruloyl-1,4-deoxy-2,3-O-isopropylidene-4-seleno-d-ribose. These compounds underwent removal of the iso-propylidene group, to provide the corresponding hydroxycinnamoyl-1,4-deoxy-4-seleno-d-ribose. All compounds were characterized by Nuclear Magnetic Resonance (NMR) spectroscopy and High-Resolution Mass Spectrometry (HRMS). This latter technique was pivotal for ensuing cellular metabolomics analyses. In fact, after evaluating the anti-radical efficacy through 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods, which underline the massive role of the phenolic moiety in establishing efficacy, the compounds, whose cytotoxicity was first screened in two highly oxidative-stress-sensitive cells, were tested for their wound healing properties towards human HaCaT keratinocytes cells. Caffeoyl- and feruloyl selenosugars exerted a dose-dependent repair activity, while, as highlighted by the metabolomic approach, they were poorly taken up within the cells.

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Section: Resultsmentioning

confidence: 99%

“…These findings were also promoted by gelatine and alginate polymeric films enriched with SeTal [ 51 ]. Moreover, the pH-sensitive release of antioxidant Se-glycoconjugates through a flexible polymeric patch is a recent development in the field of wound healing [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Innovative Cosmeceutical Ingredients: Harnessing Selenosugar-Linked Hydroxycinnamic Acids for Antioxidant and Wound-Healing Properties

Cimmino,

De Nisco,

Piccolella

et al. 2024

Antioxidants

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“…Furthermore, our group recently developed a biocompatible, polymeric thin film for a pH-dependent release of synthetic antioxidant selenium-containing glycoconjugates, with a potential application for wound healing acceleration [ 75 ]. The antioxidant activity of the two prepared compounds is related to their peculiar structure, characterized by two active sites: a selenium atom—inserted in a sugar ring—and a phenolic moiety (namely a caffeic acid and a resveratrol residue).…”

Section: Stimuli -Responsive Systemsmentioning

confidence: 99%

Recent Advances in Stimuli-Responsive Hydrogel-Based Wound Dressing

Serpico

Iacono

Cammarano³

et al. 2023

Gels

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Polymeric materials have found increasing use in biomedical applications in the last decades. Among them, hydrogels represent the chosen class of materials to use in this field, in particular as wound dressings. They are generally non-toxic, biocompatible, and biodegradable, and they can absorb large amounts of exudates. Moreover, hydrogels actively contribute to skin repair promoting fibroblast proliferation and keratinocyte migration, allowing oxygen to permeate, and protecting wounds from microbial invasion. As wound dressing, stimuli-responsive systems are particularly advantageous since they can be active only in response to specific environmental stimuli (such as pH, light, ROS concentration, temperature, and glucose level). In this review, we briefly resume the human skin’s structure and functions, as well as the wound healing phases; then, we present recent advances in stimuli-responsive hydrogels-based wound dressings. Lastly, we provide a bibliometric analysis of knowledge produced in the field.

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“…38,39 They have many unique benefits that they offer during the wound healing process: (1) they stick well to both wet and dry wound sites; 40,41 (2) they maintain the moist microenvironment at the wound site, which promotes cell growth; 39,[42][43][44][45] (3) because they are colloidal, they can collect exudates at the wound bed and then turn into a gel-like state, which promotes autolytic debridement and prevents leakage; 46,47 and (4) they make oxygen permeability easier, among other advantages (Table 1). 48 This review systematically delves into the deployment of hydrogel materials in the context of wound healing, aligning with the specific attributes of each stage. This publication presents a thorough synopsis of the several stages that are involved in skin wound repair, emphasizing the critical elements that impact each stage.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive exploration of hydrogel applications in multi-stage skin wound healing

Lu,

Wang,

Wang

et al. 2024

Biomater. Sci.

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pH-sensitive release of antioxidant Se-glycoconjugates through a flexible polymeric patch

Cited by 7 publications

References 56 publications

Innovative Cosmeceutical Ingredients: Harnessing Selenosugar-Linked Hydroxycinnamic Acids for Antioxidant and Wound-Healing Properties

Innovative Cosmeceutical Ingredients: Harnessing Selenosugar-Linked Hydroxycinnamic Acids for Antioxidant and Wound-Healing Properties

Recent Advances in Stimuli-Responsive Hydrogel-Based Wound Dressing

A comprehensive exploration of hydrogel applications in multi-stage skin wound healing

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