pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery

Sousa, C. T.; Nunes, Cláudia; Proença, Mariana P.; Leitão, Diana C.; Lima, José L.F.C.; Reis, Salette; Araújo, João P.; Lúcio, Marlene

doi:10.1016/j.colsurfb.2012.02.003

Cited by 23 publications

(18 citation statements)

References 18 publications

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“…by functionalizing the silica pore wall with aminosilane molecules. Such modification would only allow the NSAID release at chronic inflammatory conditions, which are often acidic [181]. Similar attempts to functionalize pore walls with amino groups have also been tried by others [182].…”

Section: Sol-gel Silica Controlled Release Of Non-steroidal Anti-inflmentioning

confidence: 96%

Silicon oxide based materials for controlled release in orthopedic procedures

Bhattacharyya

Ducheyne

2015

Advanced Drug Delivery Reviews

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Section: Sol-gel Silica Controlled Release Of Non-steroidal Anti-inflmentioning

confidence: 96%

Silicon oxide based materials for controlled release in orthopedic procedures

Bhattacharyya

Ducheyne

2015

Advanced Drug Delivery Reviews

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“…4,5 The tubular structure also provides a physical shield for the incorporated drugs and genes. 8,9 Thus, SiNTs and their derivatives have been utilized for the delivery of anti-inflammatory drugs, 10 anti-cancer drugs, 11 and oral drugs. 6,7 SiNTs are typical inorganic nanotubes and have many advantages including low-cost, production in large quantity, convenient surface functionalization, hydrophilic nature and excellent biocompatibility of silanol groups (Si-OH) and silicate skeletons (Si-O-Si) in comparison with the well-known carbon nanotubes.…”

Section: Introductionmentioning

confidence: 99%

A facilely controlled length, cytotoxicity, length-dependent and cell type-dependent cellular uptake of silica nanotubes and their applications in the delivery of immunostimulatory CpG oligodeoxynucleotides

et al. 2015

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A controllable length of inorganic nanotubes as a drug delivery system is crucial to understanding internalization mechanisms and designing new biomedical applications. In this study, silica nanotubes (SiNTs) with controlled length ranging from several hundred nanometers to several micrometers were firstly fabricated via a facile and effective acid-degradation collagen template route and then functionalized with chitosan (ChSiNTs) to deliver immunostimulatory cytosine-phosphodiester-guanine oligodeoxynucleotides (CpG ODNs). It was found that the length of SiNTs could be well controlled through the adjustment of the acid-treatment temperature. Cytotoxic assessment indicated that SiNTs exhibited good biocompatibility when separately incubated with four types of cell lines: 293XL-hTLR9, A549, NIH3T3, and C2C12. The cellular uptake of SiNTs was strongly affected by their length and cell type. A decrease in the length led to an increase in the cellular uptake of SiNTs, while a significantly higher cellular uptake by C2C12 cells was observed in comparison with A549 and NIH3T3 cells. An immunochemical assay revealed that SiNTs were located in the endolysosomes after cellular internalization. ChSiNTs were positive and well complexed with negative CpG ODNs to produce a ChSiNT/CpG ODN complex (CpG-ChSiNT) via electric force. ChSiNTs were located in the endolysosomes after internalization and enhanced the cellular uptake of CpG-ODNs. CpG ODNs could be released from CpG-ChSiNTs in a sustained way and specifically recognized by the TLR9 receptor in 293XL-hTLR9 cells. The amount of interleukin-6 cytokine stimulated by CpG-ChSiNT against peripheral blood mononuclear cells was higher than that by free CpG ODNs and ChSiNTs significantly enhanced the immunostimulatory response of CpG ODNs.

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“…Similar studies for Daya Bay were carried out in [30]. A search for sterile neutrinos using MINOS was done in [31]. A constraint on the mixing angle θ 14 from a combination of Solar and KamLAND data was given in [32,33].…”

Section: Introductionmentioning

confidence: 99%

Probing sterile neutrino parameters with Double Chooz, Daya Bay and RENO

Bora

Dutta

Ghoshal

2012

J. High Energ. Phys.

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In this work, we present a realistic analysis of the potential of the presentday reactor experiments Double Chooz, Daya Bay and RENO for probing the existence of sterile neutrinos. We present exclusion regions for sterile oscillation parameters for each of these experiments, using simulations with realistic estimates of systematic errors and detector resolutions, and compare the sterile parameter sensitivity regions we obtain with the existing bounds from other reactor experiments. We find that these experimental setups give significant bounds on the parameter Θ ee especially in the low sterile oscillation region 0.01 < ∆m 2 41 < 0.05 eV 2 . These bounds can add to our understanding of the sterile neutrino sector since there is still a tension in the allowed regions from different experiments for sterile parameters.

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pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery

Cited by 23 publications

References 18 publications

Silicon oxide based materials for controlled release in orthopedic procedures

Silicon oxide based materials for controlled release in orthopedic procedures

A facilely controlled length, cytotoxicity, length-dependent and cell type-dependent cellular uptake of silica nanotubes and their applications in the delivery of immunostimulatory CpG oligodeoxynucleotides

Probing sterile neutrino parameters with Double Chooz, Daya Bay and RENO

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