pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery

Cai, Xiaoli; Luo, Yanan; Zhang, Weiying; Du, Dan; Lin, Yuehe

doi:10.1021/acsami.6b04933

Cited by 298 publications

(167 citation statements)

References 40 publications

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“…The nitrogen content of N‐CQDs surface was studied by a standard curve of the nitrogen content of glycine obtained. UV‐Vis measured the absorbance of the test solution to be 2.505. The nitrogen content was calculated to be 1.98 ug/mL according to the fitting curve, and the nitrogen content of N‐CQDs was calculated to be 19.8%, which indicates that N‐CQDs with higher nitrogen content were successfully prepared.…”

Section: Resultsmentioning

confidence: 99%

pH‐sensitive carbon quantum dots−doxorubicin nanoparticles for tumor cellular targeted drug delivery

Bao

Hollywood

Wang

et al. 2019

Polymers for Advanced Techs

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A kind of pH‐responsive carbon quantum dots−doxorubicin nanoparticles drug delivery platform (D‐Biotin/DOX‐loaded mPEG‐OAL/N‐CQDs) was designed and synthesized. The system consists of fluorescent carbon dots as cross‐linkers, and D‐Biotin worked as targeting groups, which made the system have a pH correspondence, doxorubicin hydrochloride (DOX) as the target drug, oxidized sodium alginate (OAL) as carrier materials. Ultraviolet (UV)‐Vis spectrum showed that the drug‐loading rate of DOX is 10.5%, and the drug release in vitro suggested that the system had a pH response and tumor cellular targeted, the drug release rate is 65.6% at the value of pH is 5.0, which is much higher than that at the value of pH is 7.4. The cytotoxicity test and laser confocal fluorescence imaging showed that the synthesized drug delivery system has high cytotoxicity to cancer cells, and the drug‐loaded nanoparticles could enter the cells through endocytosis.

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Section: Resultsmentioning

confidence: 99%

pH‐sensitive carbon quantum dots−doxorubicin nanoparticles for tumor cellular targeted drug delivery

Bao

Hollywood

Wang

et al. 2019

Polymers for Advanced Techs

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“…Thus, Dox in aqueous medium, by itself, should produce bioactive molecules that might alter the photophysical properties of QD. Furthermore, owing to its widespread use, Dox has been conjugated with QDs so as to enhance its delivery in cells as part of the burgeoning NPDD research frontier . Dauno, with similar usage as Dox, also produces bioactive molecules and promotes ROS production in cells with interesting differences compared to Dox .…”

Section: Methodsmentioning

confidence: 99%

“…Beyond detection and quantification of ROS, QDs are being developed for nanoparticle‐mediated drug delivery (NPDD; especially cancer drug delivery) . For instance, QDs have been conjugated with the chemotherapeutic drug, doxorubicin, for targeted delivery against lung cancer . Interestingly, QDs themselves generate or modulate ROS production in cells, in bioactive molecules and in inorganic media .…”

Section: Introductionmentioning

confidence: 99%

Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Lee¹,

Suresh²,

Ekpenyong³

2018

Journal of Biophotonics

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Quantum dots (QDs) are semiconductor nanoparticles ranging in size from 2 to 10 nm. QDs are increasingly being developed for biomedical imaging, targeted drug delivery and green energy technology. These have led to much research on QD interactions with various physical, chemical and biological systems. For biological systems, research has focused on the biocompatibility/cytotoxicity of QDs in the context of imaging/therapy. However, there is a paucity of work on how biological systems and bioactive molecules might be used to alter the optoelectronic properties of QDs. Here, it is shown that these properties can be altered by reactive oxygen species (ROS) from chemotherapeutic media and biological cells following controlled changes in cellular activities. Using CdSe/ZnS core-shell QDs, spectroscopic analysis of optically excited QDs with HL60, K562 and T98G cancer cell lines is performed. Our results show statistically significant (P < 0.0001) modulation of the fluorescence emission spectra of the QDs due to the ROS produced by common chemotherapeutic drugs, daunorubicin and doxorubicin and by cells following chemotherapy/radiotherapy. This optical modulation, in addition to assessing ROS generation, will possibly enhance applications of QDs in simultaneous diagnostic imaging and nanoparticle-mediated drug delivery as well as simultaneous ROS assessment and radiosensitization for improved outcomes in cancer treatments. Reactive molecular species produced by biological cells and chemotherapeutic drugs can create electric fields that alter the photophysical properties of QDs, and this can be used for concurrent monitoring of cellular activities, while inducing changes in those cellular activities. K E Y W O R D Scancer, chemotherapy, fluorescence, quantum dot, radiotherapy, reactive oxygen species

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“…Cai et al used pH-responsive ZnO-QDs coordinated with doxorubicin for targeted drug delivery using hyaluronic acid conjugation [63]. They have shown efficient anti-cancer effect of the ZnO-QDs due to dual effect of Zn 2+ and doxorubicin.…”

Section: Inorganic Nanomaterialsmentioning

confidence: 99%

Evolution and clinical translation of drug delivery nanomaterials

et al. 2017

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With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their effective targeting that in turn reduces systemic toxicity compared to the conventional routes of drug administration. Even though these materials offer broad flexibility based on targeting tissue, disease, and drug payload, the demand for more effective yet highly biocompatible nanomaterial-based drugs is increasing. While therapeutically improved and safe materials have been introduced in nanomedicine platforms, issues related to their degradation rates and bio-distribution still exist, thus making their successful translation for human use very challenging. Researchers are constantly improving upon novel nanomaterials that are safer and more effective not only as therapeutic agents but as diagnostic tools as well, making the research in the field of nanomedicine ever more fascinating. In this review stress has been made on the evolution of nanomaterials that have been approved for clinical applications by the United States Food and Drug Administration Agency (FDA).

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pH-Sensitive ZnO Quantum Dots–Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery

Cited by 298 publications

References 40 publications

pH‐sensitive carbon quantum dots−doxorubicin nanoparticles for tumor cellular targeted drug delivery

pH‐sensitive carbon quantum dots−doxorubicin nanoparticles for tumor cellular targeted drug delivery

Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Evolution and clinical translation of drug delivery nanomaterials

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