pH-sensitivity control of PEG-poly(β-amino ester) block copolymer micelle

Hwang, Su Jong; Kim, Min Sang; Han, Jong Kwon; Lee, Sang Soo; Kim, Bong Sup; Choi, Eun Kyung; Park, Heon Joo; Kim, Jin Seok

doi:10.1007/bf03218811

Cited by 43 publications

(15 citation statements)

References 22 publications

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“…Poly(b-amino ester) (PAE) is another polymer that could be ionized at mild low pH, which has been widely used in designing pH-sensitive degradable block copolymer [45][46][47][48][49]. Gao et al synthesized the block copolymer PEG-PAEaqueous polymer isocyanate via Michael-type step polymerization method.…”

Section: Key Termmentioning

confidence: 99%

pH-sensitive drug-delivery Systems for Tumor Targeting

et al. 2013

Ther. Deliv.

129

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Drug-delivery system responses to stimuli have been well investigated recently. As pH decrease is observed in most solid tumors, drug-delivery systems responsive to the slightly acidic extracellular pH environment of solid tumors have been developed as a general strategy for tumor targeting. Drug vehicles that are sensitive to acidic endosome/lysosome pH have been constructed for efficient drug release in tumor cells. This review explains the mechanisms of acidic pH in the tumor microenvironment and endocytic-related organelles, endosomes and lysosomes. Nanoparticle responses to acidic extracellular pH are discussed, along with approaches for improving tumor-specific therapy. Endosome/lysosome pH-triggered vehicles are reviewed, which achieve rapid drug release in tumor cells and overcome multidrug resistance.

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Section: Key Termmentioning

confidence: 99%

pH-sensitive drug-delivery Systems for Tumor Targeting

et al. 2013

Ther. Deliv.

129

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“…Then, properties of these biodegradable and pH-sensitive materials were also investigated. In 2006, Ko et al 29 and Hwang et al 30 designed and synthesized a novel pH-response micelle self-assembled from diblock polymer poly(ethylene glycol)-β-PAE, which was used as an anticancer drug carrier, exhibiting controlled release behavior with change of pH. In previous studies, our team also synthesized amphiphilic block copolymer with random hydrophobic/pH-sensitive structure of poly(ethylene glycol) methyl ether-β-(polylactic acid-co-poly[β-amino esters]) (MPEG-β-[PLA-co-PAE]) and doxorubicin (DOX) selected as the model drug, and some results have been achieved.…”

Section: Zhang Et Almentioning

confidence: 99%

Self-assembled micelles based on pH-sensitive PAE-g-MPEG-cholesterol block copolymer for anticancer drug delivery

Zhang¹,

Xiong²,

Sun³

et al. 2014

IJN

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A novel amphiphilic triblock pH-sensitive poly( β -amino ester)- g -poly(ethylene glycol) methyl ether-cholesterol (PAE- g -MPEG-Chol) was designed and synthesized via the Michael-type step polymerization and esterification condensation method. The synthesized copolymer was determined with proton nuclear magnetic resonance and gel permeation chromatography. The grafting percentages of MPEG and cholesterol were determined as 10.93% and 62.02%, calculated from the area of the characteristic peaks, respectively. The amphiphilic copolymer was confirmed to self-assemble into core/shell micelles in aqueous solution at low concentrations. The critical micelle concentrations were 6.92 and 15.14 mg/L at pH of 7.4 and 6.0, respectively, obviously influenced by the changes of pH values. The solubility of pH-responsive PAE segment could be transformed depending on the different values of pH because of protonation–deprotonation of the amino groups, resulting in pH sensitivity of the copolymer. The average particle size of micelles increased from 125 nm to 165 nm with the pH decreasing, and the zeta potential was also significantly changed. Doxorubicin (DOX) was entrapped into the polymeric micelles with a high drug loading level. The in vitro DOX release from the micelles was distinctly enhanced with the pH decreasing from 7.4 to 6.0. Toxicity testing proved that the DOX-loaded micelles exhibited high cytotoxicity in HepG2 cells, whereas the copolymer showed low toxicity. The results demonstrated how pH-sensitive PAE- g -MPEG-Chol micelles were proved to be a potential vector in hydrophobic drug delivery for tumor therapy.

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“…Lee's group later developed the pH-sensitive carrier micelles self-assembled from poly (ethylene glycol)-b-poly (b-amino ester). Camptothecin (CPT) and doxorubicin (DOX) were selected as a result of the model medicine and a couple of results are achieved [102,[107][108][109] .…”

Section: Drug Deliverymentioning

confidence: 99%

Block Copolymer Nanostructures and Their Applications: A Review

Singh

Thakre

et al. 2015

Polymer-Plastics Technology and Engineering

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Block copolymer nanostructures (BCPNs) are smart, intelligent and environment sensitive nanostructures designed to respond, in a controlled manner to an external stimulus. BCPNs are being extensively utilized in pharmaceutical field, nanotechnology and in forensics. Upon micellization the hydrophobic core of BCPNs region serves as a reservoir for hydrophobic medication, which can be loaded by chemical, physical, or electrostatic means. DNA combined with synthetic BCPN enhances the chemical and biological behaviors of bio-macromolecule and at the same time completely suppress undesirable properties. Novel NEMS/MEMS devices are being realized using BCPNs and DNA combined with inorganic materials nanoparticles and small organic moieties.

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pH-sensitivity control of PEG-poly(β-amino ester) block copolymer micelle

Cited by 43 publications

References 22 publications

pH-sensitive drug-delivery Systems for Tumor Targeting

pH-sensitive drug-delivery Systems for Tumor Targeting

Self-assembled micelles based on pH-sensitive PAE-g-MPEG-cholesterol block copolymer for anticancer drug delivery

Block Copolymer Nanostructures and Their Applications: A Review

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pH-sensitivity control of PEG-poly(β-amino ester) block copolymer micelle

Cited by 43 publications

References 22 publications

pH-sensitive drug-delivery Systems for Tumor Targeting

pH-sensitive drug-delivery Systems for Tumor Targeting

Self-assembled micelles based on pH-sensitive PAE-g-MPEG-cholesterol block copolymer for&nbsp;anticancer drug delivery

Block Copolymer Nanostructures and Their Applications: A Review

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Self-assembled micelles based on pH-sensitive PAE-g-MPEG-cholesterol block copolymer for anticancer drug delivery