1977
DOI: 10.1111/j.1600-0609.1977.tb02095.x
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Ph1‐Negative Eosinophilic Leukaemia with Trisomy 8 Case Report and Review of Cytogenetic Studies

Abstract: A case of eosinophilic leukaemia of the mature cell type in a 73-year-old man is described. Bone marrow chromosomes were studied in direct preparations on 3 occasions. With the Gand Q-banding techniques an extra chromosome number 8 was observed in all metaphases. There was no Phl-chromosome. Therapy with vincristine and prednisone produced remissions but the course of the disease was accelerated. Review of the literature and study of the present case suggests that eosinophilic leukaemia like CGL may be divided… Show more

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Cited by 33 publications
(5 citation statements)
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“…It was well documented that monosomy 7 is an indicator of very poor prognosis in AML with an estimated 4-year overall survival of 4% [12]. Chromosomal abnormalities detected in the remaining three patients have already been described in patients with CEL, both as a single abnormality or as a part of a complex karyotype [13][14][15]. At least one of this finding was associated with AT [14].…”
mentioning
confidence: 94%
“…It was well documented that monosomy 7 is an indicator of very poor prognosis in AML with an estimated 4-year overall survival of 4% [12]. Chromosomal abnormalities detected in the remaining three patients have already been described in patients with CEL, both as a single abnormality or as a part of a complex karyotype [13][14][15]. At least one of this finding was associated with AT [14].…”
mentioning
confidence: 94%
“…Before the banding technique became available, Chusid et al (8) reported that 7 out of 13 investigated patients with the hypereosinophilic syndrome had abnormal karyotypes. One of these patients had a Ph' in all bone marrow metaphases and another six Ph'-positive patients have been described (27). A case with a double Phl has been reported recently (1).…”
Section: Resultsmentioning
confidence: 99%
“…As noted above, the nature of the hypereosinophilic syndrome has been much debated. Arguments that this syndrome, including Loffler's endocarditis blood (8, 28), impaired eosinophilic maturation (5) and, most important, chromosomal aberrations in the bone marrow cells (5,8,27).…”
Section: Resultsmentioning
confidence: 99%
“…Second Int. Workshop 198Oe SHILOH et al 1979SOKAL et al 1975TABACHNIK et al 1979VAN DEN BERGHE et al 197% VERHESI et al 1976WEINFELD et al 1977bZACCARIA et al 1980 Japan BAGBY et al 1978BIlRAN et al 1977BRODEUR et al 1979DIBENDElTO et al 1979ELLMAN et al 1979FINDLEY et al 1979H. HOEHN pers.…”
Section: Burkitt's Lymphoma (Bl)mentioning
confidence: 99%