pH switchable Pickering emulsion based on soy peptides functionalized calcium phosphate particles

Ruan, Qijun; Guo, Jian; Wan, Zhinian; Ren, Jiaoyan; Yang, Xiaoquan

doi:10.1016/j.foodhyd.2017.03.023

Cited by 34 publications

(25 citation statements)

References 37 publications

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“…7b). Similar demulsification by acid has been reported for emulsions stabilized by hydroxyapatite or calcium phosphate particles [11,12]. From the standpoint of dietary calcium, such acid-responsive disintegration of the CaCO 3 NPs would be an effective means for providing Ca 2+ for physiological use.…”

Section: Responsiveness Of the Caco 3 Np-based Pickering Emulsion Undsupporting

confidence: 66%

“…In the recent decade, there has been growing research interest in assembling particles using ''generally regarded as safe'' (GRAS) inorganic materials, such as hydroxyapatite, calcium phosphate, tri-calcium phosphate, and calcium carbonate, to maximize emulsion stabilization and minimize side effects [10][11][12][13]. Among the vast variety of materials, food-grade calcium carbonate (CaCO 3 ) has gained attention as a Pickering emulsifier, particularly in the food, pharmacy, and medical industries [14], as it is of substantial importance for three main reasons: (1) CaCO 3 is a recognized food additive and pharmaceutical ingredient that is advantageous for its low-cost and availability in large quantities [3]; (2) CaCO 3 particles can impart acid-responsive properties into the Pickering emulsion it stabilizes by virtue of its acid-soluble nature [15]; (3) functional properties (calcium fortification and acid neutralization capacity) can also be added to the Pickering emulsion after converting CaCO 3 particles into absorbable calcium ions once exposed to gastric acid [16].…”

Section: Introductionmentioning

confidence: 99%

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Edible CaCO3 nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation

Guo

Chan

et al. 2021

J Nanobiotechnol

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Background Nanoparticles assembled from food-grade calcium carbonate have attracted attention because of their biocompatibility, digestibility, particle and surface features (such as size, surface area, and partial wettability), and stimuli-responsiveness offered by their acid-labile nature. Results Herein, a type of edible oil-in-water Pickering emulsion was structured by calcium carbonate nanoparticles (CaCO3 NPs; mean particle size: 80 nm) and medium-chain triglyceride (MCT) for delivery of lipophilic drugs and simultaneous oral supplementation of calcium. The microstructure of the as-made CaCO3 NPs stabilized Pickering emulsion can be controlled by varying the particle concentration (c) and oil volume fraction (φ). The emulsification stabilizing capability of the CaCO3 NPs also favored the formation of high internal phase emulsion at a high φ of 0.7–0.8 with excellent emulsion stability at room temperature and at 4 °C, thus protecting the encapsulated lipophilic bioactive, vitamin D3 (VD3), against degradation. Interestingly, the structured CaCO3 NP-based Pickering emulsion displayed acid-trigged demulsification because of the disintegration of the CaCO3 NPs into Ca2+ in a simulated gastric environment, followed by efficient lipolysis of the lipid in simulated intestinal fluid. With the encapsulation and delivery of the emulsion, VD3 exhibited satisfying bioavailability after simulated gastrointestinal digestion. Conclusions Taken together, the rationally designed CaCO3 NP emulsion system holds potential as a calcium-fortified formulation for food, pharmaceutical and biomedical applications.

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Section: Responsiveness Of the Caco 3 Np-based Pickering Emulsion Undsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Edible CaCO3 nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation

Guo

Chan

et al. 2021

J Nanobiotechnol

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“…The pepsin-released peptides derived from soybean 7S globulin (7S-peptides) were prepared according to the method described in our previous study . 7S-Peptides were prepared by using pepsin digestion combined with the ultrafiltration fractionation method.…”

Section: Methodsmentioning

confidence: 99%

Interaction of Soybean 7S Globulin Peptide with Cell Membrane Model via Isothermal Titration Calorimetry, Quartz Crystal Microbalance with Dissipation, and Langmuir Monolayer Study

Zou

Pan

Ruan

et al. 2018

J. Agric. Food Chem.

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To understand the underlying molecular mechanism of the cholesterol-lowering effect of soybean 7S globulins, the interactions of their pepsin-released peptides (7S-peptides) with cell membrane models consisting of dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylcholine (DOPC), and cholesterol (CHOL) were systematically studied. The results showed that 7S-peptides were bound to DPPC/DOPC/CHOL liposomes mainly through van der Waals forces and hydrogen bonds, and the presence of higher CHOL concentrations enhanced the binding affinity (e.g., DPPC/DOPC/CHOL = 1:1:0, binding ratio = 0.114; DPPC/DOPC/CHOL = 1:1:1, binding ratio = 2.02). Compression isotherms indicated that the incorporation of 7S-peptides increased the DPPC/DOPC/CHOL monolayer fluidity and the lipid raft size. The presence of CHOL accelerated the 7S-peptide accumulation on lipid rafts, which could serve as platforms for peptides to develop into β-sheet rich structures. These results allow us to hypothesize that 7S-peptides may indirectly influence membrane protein functions via altering the membrane organization in the enterocytes.

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“…Biocompatible materials including polysaccharides like chitosan, [68,69] soy peptides, [70] lignin [71] and alginic acid [72,73] show excellent potential as emulsifiers and emulsifiermodification agents in stimuli-responsive Pickering emulsions. This is due to the abundance of pH-responsive functional groups in their structures, such as amines, hydroxyls, and carbonyls, which can cross-link and dissociate or decompose accordingly to stabilise or destabilise the emulsion systems.…”

Section: Ph Responsive Pickering Emulsionsmentioning

confidence: 99%

Recent developments in Pickering emulsions for biomedical applications

Harman

Patel

Guldin

et al. 2019

Current Opinion in Colloid & Interface Science

141

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Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.Pickering emulsions have been applied in a number of areas of research and industrial importance, such as food manufacturing, cosmetics, agrochemicals and therapeutic delivery. Their popularity in biomedical applications (i.e. for use in healthcare, such as therapeutics, diagnostics or imaging), in particular, has increased dramatically in recent years, thanks to their high stability, capacity for superior cargo loading compared to conventional systems, and diverse range of stabilising particles, creating a broad library of available building blocks. For biomedical and pharmaceutical application, the choice of emulsifier is critical; it must be biocompatible, non-toxic, and be able to be excreted from the body (if necessary). In this article, we will review the latest developments in the design and application of Pickering emulsions for biomedicine, with a focus on stimuli-responsive Pickering emulsions as a route to the triggered release of a payload towards advanced therapeutic delivery strategies. Within this discussion, we will describe systems which have been applied in proof of concept and in vitro assessments and emphasise areas of potential future development.

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pH switchable Pickering emulsion based on soy peptides functionalized calcium phosphate particles

Cited by 34 publications

References 37 publications

Edible CaCO3 nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation

Edible CaCO3 nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation

Interaction of Soybean 7S Globulin Peptide with Cell Membrane Model via Isothermal Titration Calorimetry, Quartz Crystal Microbalance with Dissipation, and Langmuir Monolayer Study

Recent developments in Pickering emulsions for biomedical applications

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