pH/temperature-responsive behaviors of semi-IPN and comb-type graft hydrogels composed of alginate and poly( N -isopropylacrylamide)

Ju, Hee Kyung; Kim, So Yeon; Lee, Young Moo

doi:10.1016/s0032-3861(01)00143-4

Cited by 271 publications

(147 citation statements)

References 11 publications

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“…Currently, the creation of responsive ionically cross-linked hydrogels is done mainly through utilization of their pH and thermal responses. This approach was used for fabrication of calcium cross-linked alginate membranes actuated by chemoenzymatic systems [19,20], thermoresponsive alginate-PNIPAAm hydrogels [21,22], and electrical responsive alginate/poly(diallyldimethylammonium chloride) [23]. However, neither of these systems provides the spatial control that is necessary for fabrication of complex porous scaffolds and dynamic control of the gel formation and dissolution.…”

Section: Open Accessmentioning

confidence: 99%

Photochemical Patterning of Ionically Cross-Linked Hydrogels

2013

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Iron(III) cross-linked alginate hydrogel incorporating sodium lactate undergoes photoinduced degradation, thus serving as a biocompatible positive photoresist suitable for photochemical patterning. Alternatively, surface etching of iron(III) cross-linked hydrogel contacting lactic acid solution can be used for controlling the thickness of the photochemical pattering. Due to biocompatibility, both of these approaches appear potentially useful for advanced manipulation with cell cultures including growing cells on the surface or entrapping them within the hydrogel.

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Section: Open Accessmentioning

confidence: 99%

Photochemical Patterning of Ionically Cross-Linked Hydrogels

2013

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“…Therefore, the most recent research has focused on synthetic/natural polymer blend materials such as cellulose diacetate/PVP, 6 starch/PVA, 7 KC/ poly(diallyl dimethyl ammonium chloride), 8 chitosan/PVP, chitosan/PVA, chitosan/poly(ethylene oxide), 9 alginate/poly(N-isopropyl acrylamide), 10 and agar/PVP/poly(ethylene glycol) (PEG).…”

Section: Introductionmentioning

confidence: 99%

Radiation synthesis of poly(N‐vinyl‐2‐pyrrolidone)–κ‐carrageenan hydrogels and their use in wound dressing applications. I. Preliminary laboratory tests

Şen

Avcı

2005

J Biomedical Materials Res

101

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Poly(N-vinyl-2-pyrrolidone)--carrageenan hydrogels (PVP-KC) were prepared by irradiating the mixtures of aqueous solutions of PVP, KC, potassium chloride, and poly(ethylene glycol) by ␥-rays at different doses. Their preliminary laboratory tests were evaluated to identify their usability in wound dressing applications. For investigation of the effect of components on the gelation of PVP, sol-gel analyses were made and gel fractions of the hydrogels were determined. Mechanical experiments were conducted for both unirradiated and irradiated samples. For investigation of the fluid uptake capacity of the hydrogels, swelling experiments were performed in pseudo-extracellular fluid solution at various temperatures. Acidity/alkalinity (pH) and electrical conductivity tests were achieved from aqueous extracts of hydrogels, and bioadhesion strength of the hydrogels was investigated on human skin.

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“…As a pH-sensitive natural material, alginate is relatively low cost [25]. As a result, alginate is often selected as a matrix for the entrapment and delivery of proteins, drugs, and cells because of its biocompatiblity and biodegradability under the normal physiological conditions [26][27][28]. Recently, it was reported that many amino acid moieties have been attractive candidates for synthesizing hydrogel materials to improve their biodegradability and biocompatibility [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure

Deng¹,

Zhong²,

Tian³

et al. 2010

Express Polym. Lett.

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Abstract. In this study, a novel pH/temperature sensitive hydrogel bead with core-shelled structure, composed of calcium alginate (Ca-alginate) and poly(N-acryloylglycine) (PAG), was prepared using as a drug delivery system. The equilibrium swelling has indicated the distinct sensitivities of the beads to pH value and temperature. In pH = 7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the core of the beads was about 83.5% within 650 min, whereas this value only reached 16.6% in pH = 2.1 PBS. In addition, the release rate of indomethacin was much faster at 37°C than that at 24°C. The experimental results have showed that the Ca-alginate/PAG beads have a potential application for the pH/temperature-controlled drug release carrier in the biomedical field.

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pH/temperature-responsive behaviors of semi-IPN and comb-type graft hydrogels composed of alginate and poly( N -isopropylacrylamide)

Cited by 271 publications

References 11 publications

Photochemical Patterning of Ionically Cross-Linked Hydrogels

Photochemical Patterning of Ionically Cross-Linked Hydrogels

Radiation synthesis of poly(N‐vinyl‐2‐pyrrolidone)–κ‐carrageenan hydrogels and their use in wound dressing applications. I. Preliminary laboratory tests

Drug release behavior of a pH/temperature sensitive calcium alginate/poly(N-acryloylglycine) bead with core-shelled structure

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