pH/Temperature-Responsive Polymer Composed of Poly((N,N-dimethylamino)ethyl methacrylate-co-ethylacrylamide)

Yuk, Soon Hong; Cho, Sun Hang; Lee, Sang Hoon

doi:10.1021/ma970725w

Cited by 164 publications

(92 citation statements)

References 19 publications

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“…[8][9][10][11] The properties of these polymer types can be further engineered for multi-parameter responses (temperature and pH) by copolymerization with ionisable co-monomers. 12,13 Copolymers of N-isopropylacrylamide (NIPAM) and N-tert-butylacrylamide (NtBA) with different NIPAM to NtBA molar ratios are one model where the polymer structure has been modified to mediate LCST behavior. These NIPAM/NtBA copolymers are currently being investigated as potential drug elution matrices and for cell culture applications.…”

Section: Introductionmentioning

confidence: 99%

Measuring the Micro-Polarity and Hydrogen-Bond Donor/Acceptor Ability of Thermoresponsive N-Isopropylacrylamide/N-tert-Butylacrylamide Copolymer Films Using Solvatochromic Indicators

et al. 2009

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Thin polymer films are important in many areas of biomaterials research, biomedical devices, and biological sensors. The accurate in situ measurement of multiple physicochemical properties of thin polymer films is critical in understanding biocompatibility, polymer function, and performance. In this work we demonstrate a facile spectroscopic methodology for accurately measuring the micro-polarity and hydrogen-bond donor/acceptor ability for a series of relatively hydrophilic thermoresponsive copolymers. The micro-polarity of the N-isopropylacrylamide (NIPAM) and N-tert-butylacrylamide (NtBA) co-polymers was evaluated by means of the ET(30), α, β, and π* empirical solvatochromic polarity parameters. The data shows that increasing the NtBA fraction in the dry copolymer film reduces polarity and hydrogen-bonding ability. Within the Kamlet–Taft polarity framework, the NIPAM/NtBA copolymer films are strong hydrogen-bond acceptors, strongly dipolar/polarizable, and rather moderate hydrogen-bond donors. This characterization provides a more comprehensive physicochemical description of polymers, which aids the interpretation of film performance. Comparison of the measured ET(30) values with literature data for other water-soluble polymers show that dry NIPAM/NtBA copolymers are slightly more polar than poly(ethylene oxide), less polar than polyvinyl-alcohol, and approximately the same polarity as poly(N-vinyl-2-pyrrolidone). These findings indicate that this spectroscopic method is a facile, rapid, and nondestructive methodology for measuring polymer properties in situ, suitable for most biomaterials research laboratories.

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Section: Introductionmentioning

confidence: 99%

Measuring the Micro-Polarity and Hydrogen-Bond Donor/Acceptor Ability of Thermoresponsive N-Isopropylacrylamide/N-tert-Butylacrylamide Copolymer Films Using Solvatochromic Indicators

et al. 2009

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“…Also, the block copolymer exhibited a slight hysteresis in cloud point temperature between the heating and the cooling cycles (T cp = 30°C for heating and T cp = 26°C for cooling), which has also been observed for thermo-responsive polymers bearing tertiary amines [40][41][42]. It is generally attributed to the inter-polymer hydrogen bonding of the tertiary amine groups [42,43]. In DLS measurements, the hydrodynamic diameter D h was below 100 nm at low temperature for all cases and sharply increased to above 130 nm when the critical temperature was reached, illustrating the transformation from small micelles to large aggregated particles upon heating.…”

Section: Thermo-responsive Behavior Illustratedmentioning

confidence: 53%

“…This can be ascribed to the presence of the hydrophobic PPA segment, which tends to suppress the LCST of the copolymer [38][39][40]. Also, the block copolymer exhibited a slight hysteresis in cloud point temperature between the heating and the cooling cycles (T cp = 30°C for heating and T cp = 26°C for cooling), which has also been observed for thermo-responsive polymers bearing tertiary amines [40][41][42]. It is generally attributed to the inter-polymer hydrogen bonding of the tertiary amine groups [42,43].…”

Section: Thermo-responsive Behavior Illustratedmentioning

confidence: 62%

Thermo-responsive, UV-active poly(phenyl acrylate)-b-poly(diethyl acrylamide) block copolymers

Wang¹,

Lessard²,

Marić

2013

Express Polym. Lett.

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Abstract. The homopolymerization of phenyl acrylate (PA) was investigated for the first time by nitroxide mediated polymerization (NMP) with the succinimidyl form of the SG1-based unimolecular initiator 2-[N-tert-butyl-2,2-(dimethylpropyl)-aminooxy]propionic acid (BlocBuilder MA). The control of PPA homopolymerization was improved by the use of 15 mol% additional free nitroxide SG1 ([tert-butyl[1-(diethoxyphosphoryl)-2,2-dimethylpropyl]amino]oxidanyl) and dispersities, M w /M n , of around 1.2 were achieved. A PPA homopolymer was then successfully chain-extended with diethyl acrylamide (DEAAm) to form a block copolymer of PPA-b-PDEAAm where the PDEAAm segment is thermo-responsive, while the PPA block is potentially UV-active. The thermo-responsive behavior of the block copolymer in 0.5 wt% aqueous solution was studied by UV-Vis spectrometry and dynamic light scattering (DLS), indicating cloud point temperatures of 26-30°C, close to that reported for PDEAAm homopolymers.

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“…In recent years, polymer systems that respond to more than one stimulus such as pH and temperature have received considerable research attention [11][12][13][14]. To prepare polymers that respond to more than one stimulus, monomers that are sensitive to certain stimuli have to be copolymerized.…”

Section: Open Accessmentioning

confidence: 99%

Solution Properties of Water-Soluble “Smart” Poly(N-acryloyl-N′-ethyl piperazine-co-methyl methacrylate)

Deen

2012

Polymers

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Water-soluble copolymers of N-acryloyl-N′-ethylpiperazine (AcrNEP) with methyl methacrylate (MMA) were synthesized to high conversion by free-radical solution polymerization. The composition of the copolymers was determined using Fourier Transform Infra-red Spectroscopy (FTIR). Copolymers containing AcrNEP content above 44 mol% were readily soluble in water and exhibited the critical solution temperature behavior. The copolymers were strongly responsive to changes in pH of the external medium due to the presence of tertiary amine functions that could be protonated at low pH. The influence of various factors such as copolymer composition, pH, temperature, salt and surfactant concentration on the LCST of the copolymers were systematically studied. The intrinsic viscosity of the copolymers in dimethyl formamide decreased with increase in temperature due to a decrease in thermodynamic affinity between polymer chains and solvent molecules. The viscosity behavior of the copolymers in sodium chloride solution was similar to that of classical polyelectrolytes and hydrophobically modified polyacrylate systems.

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pH/Temperature-Responsive Polymer Composed of Poly((N,N-dimethylamino)ethyl methacrylate-co-ethylacrylamide)

Cited by 164 publications

References 19 publications

Measuring the Micro-Polarity and Hydrogen-Bond Donor/Acceptor Ability of Thermoresponsive N-Isopropylacrylamide/N-tert-Butylacrylamide Copolymer Films Using Solvatochromic Indicators

Measuring the Micro-Polarity and Hydrogen-Bond Donor/Acceptor Ability of Thermoresponsive N-Isopropylacrylamide/N-tert-Butylacrylamide Copolymer Films Using Solvatochromic Indicators

Thermo-responsive, UV-active poly(phenyl acrylate)-b-poly(diethyl acrylamide) block copolymers

Solution Properties of Water-Soluble “Smart” Poly(N-acryloyl-N′-ethyl piperazine-co-methyl methacrylate)

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