pH-triggered injectable hydrogels prepared from aqueous N-palmitoyl chitosan: In vitro characteristics and in vivo biocompatibility

Chiu, Ya-Ling; Chen, Sung-Ching; Su, Chun‐Jen; Hsiao, Chun-Wen; Chen, Yuming; Chen, Hsin‐Lung; Sung, Hsing‐Wen

doi:10.1016/j.biomaterials.2009.05.052

Cited by 186 publications

(115 citation statements)

References 42 publications

Supporting

Mentioning

111

Contrasting

Order By: Relevance

“…More recently, hydrophobic N-palmitoyl moieties were grafted onto chitosan (NPCS) to produce a pH-triggered hydrogel within the pH range of 6.5-7.0. [69] The G 0 of the NPCS aqueous solution at pH 6.5 was about 100 Pa ( Figure 6) and was strongly dependent on the shear rate, indicating that the NPCS aqueous solution might be able to squeeze through the needle during injection. The G 0 of the hydrogel at pH 7.0 was higher than that at pH 6.5.…”

Section: Chitosanmentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

422

343

View full text Add to dashboard Cite

Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

show abstract

Section: Chitosanmentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

422

343

View full text Add to dashboard Cite

show abstract

“…10 Gels that absorb water or biological fluids within the network are referred to as polymer hydrogels. Researchers have designed many different injectable hydrogels using pluronics, 11 chitosan, 12 and polymer-grafted nanoparticles. 13 Many physical gels display self-healing behavior, but the kinetics and the governing timescales of network healing have not been fully investigated.…”

mentioning

confidence: 99%

The impact of damage accumulation on the kinetics of network strength recovery for a physical polymer gel subjected to shear deformation

Thornell

Subramaniam

Erk

2016

J Polym Sci B Polym Phys

View full text Add to dashboard Cite

Shear rheophysical experiments were used to quantify the kinetics of strength recovery of model thermoreversible polymer gels that were fractured and ultimately sheared to different total magnitudes of strain (700 and 4000%) before resting for set periods of time. Relationships between the amount of strength recovered and the normalized ratio of resting times to characteristic relaxation times were developed. It was found that gels displayed fully healed networks within timescales that were 2-3 orders of magnitude greater than the gel's characteristic relaxation time. Gels deformed to 700% applied strain either healed slower at lower gel concentrations as compared to experiments at larger applied strains due to possible viscous heating, or healed faster from incomplete fracture propagation for higher gel concentrations.

show abstract

“…Many reports have shown that chitosan-derived materials have high biocompatibility. [27][28][29][30] Chitosan hydrogels used in the current study were fabricated using urea and urease. According to our previous work, 20 chitosan hydrogel containing 37.5 mM urea and 30 U/mL urease was used since its gelation time (11.7 -0.6 min) is suitable for clinical handling of cell encapsulation.…”

Section: Figmentioning

confidence: 99%