Ph-Triggered Release of Vancomycin from Protein-Capped Porous Silicon Films

Abstract

Recent progress in nanotechnology has triggered the site specific drug/gene delivery research and gained wide acknowledgment in contemporary DNA therapeutics. Amongst various organs, liver plays a crucial role in various body functions and in addition, the site is a primary location of metastatic tumor growth. In past few years, a plethora of nano-vectors have been developed and investigated to target liver associated cells through receptor mediated endocytosis. This emerging paradigm in cellular drug/gene delivery provides promising approach to eradicate genetic as well as acquired diseases affecting the liver. The present review provides a comprehensive overview of potential of various delivery systems, viz., lipoplexes, liposomes, polyplexes, nanoparticles and so forth to selectively relocate foreign therapeutic DNA into liver specific cell type via the receptor mediated endocytosis. Various receptors like asialoglycoprotein receptors (ASGP-R) provide unique opportunity to target liver parenchymal cells. The results obtained so far reveal tremendous promise and offer enormous options to develop novel DNA-based pharmaceuticals for liver disorders in near future.

Novel Delivery Systems for Improving the Clinical Use of Peptides

“…Targeting peptides can be grafted on the surface to enhance accumulation PSi nanoparticles into target tissue (Kinnari et al, 2013;Yokoi et al, 2013). The pores can also be capped with proteins or cyclodextrin, which enable the release of the loaded molecules at certain pH (Perelman et al, 2008;Xue et al, 2011). Furthermore, PSi particles can be encapsulated by, for example, solid lipids to improve their behavior in vivo (Liu et al, 2013b).…”

Physicochemical Properties Affect the Synthesis, Controlled Delivery, Degradation and Pharmacokinetics of Inorganic Nanoporous Materials

“…For example, pSi can be capped with poly(l-lactide) [58], poly(dl-lactide-co-glycolide) [59], agarose [60], cellular membranes [61] and hydrogels [62] allowing for the release of proteins and chemotherapeutics or act as sensors. Furthermore, these approaches enable a responsive drug delivery platform capable of delivering payloads in response to variations in temperature [63], voltage [64], proteases [65] and pH [66].…”

Controlled delivery of acyclovir from porous silicon micro- and nanoparticles

“…This low drug loading capacity of UnPSi is attributed to the steric hindrance imparted by the long chain of undecylenic acid which blocks access to the some of the pores. TOPSi particles showed least drug loading capacity since thermal oxidation shrink pore diameters and decrease open porosity which results in lower drug loading in comparison with native and UnPSi [19,39]. …”