pH/Viscosity dual-response fluorescent probes as highly selective tumor visualization tools

Human serum albumin-based supramolecular host–guest boronate probe for enhanced peroxynitrite sensing

“…28 Then, a phenylboronate, which is a known reactive group for ONOO − ,29 was introduced to the amino end of TCM-1 to produce TCM-2 with quenched fluorescence due to inhibited intramolecular charge transfer. 30 After reacting with ONOO − , the boronate moiety is removed, resulting in fluorescence recovery of the probe.…”

Fluorescent Probes as a Tool in Diagnostic and Drug Delivery Systems

“…The abnormal viscosity values are related to atherosclerosis, hypertension, diabetes, Alzheimer’s disease, and cancer [ 83 ]. Wang et al applied this for highly selective tumor visualization using TICT fluorescent probe 17 ( Figure 18 ) [ 84 ]. Similar to probes 16a-c , compound 17 showed only weak fluorescence at 555 nm due to TICT non-emissive deexcitation.…”

“…Fluorescence images of organs and tumors of tumor-bearing mice after tail vein administration of 17 (100 µM). Adapted with permission from [ 84 ]. Copyright (2023) Elsevier.…”

A novel pH-activated AIEgen probe for dynamic lysosome tracking and high-efficiency photodynamic therapy

“…11 However, there are certain problems with such probes, such as small Stokes shift, severe photobleaching, and aggregation-induced quenching (ACQ), and their applications in living organisms are limited. [12][13][14][15][16] Moreover, traditional PSs that act as protagonists in PDT have similar problems. ACQ considerably affects and reduces the generation ability of reactive oxygen species (ROS), which in turn considerably limits the effect of PDT.…”

“…Scheme S1 (ESI †) shows the synthetic steps of N-3QL and the obtained product of N-3QL is characterized using MS, 1 H NMR, and 13 C NMR spectra (Fig. S1-S3 in ESI †).…”