pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI

Harris, Robert J.; Cloughesy, Timothy F.; Liau, Linda M.; Prins, Robert M.; Antonios, Joseph; Li, Debiao; Yong, William H.; Pope, Whitney B.; Lai, Albert; Nghiemphu, Phioanh L.; Ellingson, Benjamin M.

doi:10.1093/neuonc/nov106

Cited by 100 publications

(93 citation statements)

References 30 publications

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“…pH imaging, which is a cutting‐edge application of CEST, may become a potential marker of hypoxia . A recent study showed the promising result of amine‐proton based CEST images, which focuses on 3 ppm, in detecting intratumoral pH changes . However, this effect is somewhat confusing in the assessment of brain tumor with APT images; high‐grade tumors with high proliferation activity can show acidotic changes due to anaerobic metabolism or necrosis, which causes a lactate peak in MRS .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors

Sakata

Fushimi

Okada

et al. 2017

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 99%

Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors

Sakata

Fushimi

Okada

et al. 2017

Magnetic Resonance Imaging

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“…Exploratory MRI techniques such as chemical exchange saturation transfer provide new methods of generating tumor contrast and can be used to interrogate variables such as pH, acidity, lactate levels, and other aspects of cellular metabolism and microenvironment (Harris et al, 2015, 2016; Longo et al, 2016). Chemical exchange saturation transfer has been used to distinguish recurrence from radiation necrosis in a pilot prospective study of 16 patients with brain metastases treated with SRS (Mehrabian et al, 2017).…”

Section: Caveats To Interpreting Posttreatment Imaging Changesmentioning

confidence: 99%

Brain metastases: neuroimaging

Pope

2018

Handbook of Clinical Neurology

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154

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Magnetic resonance imaging (MRI) is the cornerstone for evaluating patients with brain masses such as primary and metastatic tumors. Important challenges in effectively detecting and diagnosing brain metastases and in accurately characterizing their subsequent response to treatment remain. These difficulties include discriminating metastases from potential mimics such as primary brain tumors and infection, detecting small metastases, and differentiating treatment response from tumor recurrence and progression. Optimal patient management could be benefited by improved and well-validated prognostic and predictive imaging markers, as well as early response markers to identify successful treatment prior to changes in tumor size. To address these fundamental needs, newer MRI techniques including diffusion and perfusion imaging, MR spectroscopy, and positron emission tomography (PET) tracers beyond traditionally used 18-fluorodeoxyglucose are the subject of extensive ongoing investigations, with several promising avenues of added value already identified. These newer techniques provide a wealth of physiologic and metabolic information that may supplement standard MR evaluation, by providing the ability to monitor and characterize cellularity, angiogenesis, perfusion, pH, hypoxia, metabolite concentrations, and other critical features of malignancy. This chapter reviews standard and advanced imaging of brain metastases provided by computed tomography, MRI, and amino acid PET, focusing on potential biomarkers that can serve as problem-solving tools in the clinical management of patients with brain metastases.

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“…The chemical exchange between amine and amide protons in bulk water has been shown to be pH dependent using a new imaging method called CEST imaging . The inherently elevated concentration of glutamine within tumors further increases the available proton exchange, resulting in a higher CEST signal at 3.0 ppm . The combination of increased protons (low pH) and increased glutamine makes pH‐weighted MRI using CEST contrast from amine protons on glutamine particularly attractive as a noninvasive tool for assessment of microenvironment acidity within malignant brain tumors.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous pH‐sensitive and oxygen‐sensitive MRI of human gliomas at 3 T using multi‐echo amine proton chemical exchange saturation transfer spin‐and‐gradient echo echo‐planar imaging (CEST‐SAGE‐EPI)

Harris

Yao

Chakhoyan

et al. 2018

Magnetic Resonance in Med

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pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI

Abstract: Results suggest pH-weighted MRI may provide new insight into brain tumor physiology beyond traditional imaging technologies.

Cited by 100 publications

References 30 publications

Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors

Diagnostic performance between contrast enhancement, proton MR spectroscopy, and amide proton transfer imaging in patients with brain tumors

Brain metastases: neuroimaging

Simultaneous pH‐sensitive and oxygen‐sensitive MRI of human gliomas at 3 T using multi‐echo amine proton chemical exchange saturation transfer spin‐and‐gradient echo echo‐planar imaging (CEST‐SAGE‐EPI)

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