Phæochromocytoma

These studies demonstrated the existence of chromaffin-reacting granules in the human skin. The chromaffin reaction was provided by bichromate fixation. Subsequent special staining by the modified Sevki procedure revealed these granules to be localized usually to characteristic long, eel-like cells with distinctive tinctorial features. Although the true significance of these cells is not certain, they are believed to represent the local source of a vasopressor material for the peripheral tissues. Much indirect physiologic evidence supports this belief.

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“…That the chromaffin-reacting results from the oxidation, especially by chromates, of epinephrine, norepinephrine, or related compounds 12 …”

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confidence: 99%

Chromaffin Reacting Cells in Human Digital Skin

Burch

Phillips

1958

Circulation Research

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“…Perirenal insufflation of air is recommended by several authors. A rise of the serum potassium during hypertensive paroxysms was described by Blacklock et al (1947), while others found an increased content of adrenaline during the attacks (Beer et al, 1937;Strombeck and Hedberg, 1939).…”

Section: Discussionmentioning

confidence: 95%

“…Among these there were 16 bilateral growths (Mackeith, 1944), so that the present case is probably the 17th. * Every year several new cases are recorded (Espersen and Dahl-Iversen, 1946;Washington et al, 1946;Blacklock et al, 1947;Brunschwig, 1947;Goldenberg et al, 1947;Gutmann, 1947;Kipkie, 1947;Mandl, 1947;Schneider, 1947;Spalding, 1947). The symptoms, though essentially those of hypertension due to an excess of adrenaline production, may vary, and some authors distinguish four clinical groups: (1) paroxysmal hypertension, (2) persistent hypertension, (3) asymptomatic, and (4) malignant.…”

Section: Discussionmentioning

confidence: 99%

Case of Bilateral Phaeochromocytoma

Reid¹,

Salm²

1949

BMJ

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INJURIES TO SUPERIOR LONGITUDINAL SINUSBDAJR MEDICAL JOURNAL this does not explain why spasticity occurs at once, and indeed its occurrence is so immediate that it must be related directly to the injury rather than to the secondary pathological changes following a sinus thrombosis. In cases where operative procedure was necessarily severe a stage of shock and flaccid paresis did appear, but ten days or so after operation spasticity had again appeared, often together with the first signs of recovery.Recovery begins early and continues for a considerable time-several years at least. Its degree depends upon the degree of injury, and if this is severe spasticity and weakness remain and recovery depends upon how much this can be overcome by re-education in walking and the use of appliances. The main difficulty that these patients experience is the negotiation of uneven surfaces and inclines that require the presence of unimpaired postural sensibility in the toes and the ability to dorsiflex and plantar-flex the foot accurately. In the early stages of recovery the gait may be likened to that of a patient suffering from Little's disease, but most cases appear to progress enough to afford adequate movement at the hips and knees, and the residual disability is confined in these cases to the feet and ankles.Furthermore, although the series is small, the presence of other symptoms often associated with cranial injury do not seem to be of common occurrence-that is, such symptoms as headache, dizziness, or epileptiform attacks. Bailey, 0. T., and Hass, G. M. (1937). 60, 293. Beevor, C. E. (1907). Ibid., 30, 403. Burger, H. (1924). Acta oto-larynig., Stocklr., 6, 4. Foerster, 0. (1936). Brain, 59, 135. Holmes, G., and Sargent, P. (1915 Phaeochromocytomata are rare enough to warrant the recording of an additional case. Case ReportThe patient, a married woman aged 40, was admitted in October, 1946, complaining of generalized throbbing headaches for the past ten years. These were present by day and by night, but had increased in severity during the past two years. Sometimes after exertion or on stooping the headaches became very severe, spreading from the temporal and infraorbital regions to the vertex and occiput. These attacks lasted for two to three minutes, but the patient emphasized that she was never completely free from headaches. On moderate exertion she soon became breathless and suffered from palpitations. Weakness and loss of weight had increased, particularly during the three weeks before her admission. Her past history had been uneventful. Her family history was very interesting.Her father died at 46 of Addison's disease, though its cause (atrophy, tuberculous infection, chromaffinoma) is debatable. Of six other siblings, one brother died at 28 of diabetes, while one sister died at 29 of an obscure bone disease. She was apparently healthy up to the age of 14, when she started to " shrink." At the time of her death her body was about the size of a child of 4. The condition was regarded as that of an " acho...

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“…Attempts were made, using Schmorl's Giemsa method as modified by Sevki (1934) and Blacklock et al (1947), to demonstrate adrenaline particles, but only diffuse cytoplasmic staining was obtained. This was doubtless owing to the fact that the necropsy was performed 20 hours after death, and, for this reason also, no biological tests to demonstrate active hormone were attempted.…”

Section: Microscopymentioning

confidence: 99%

“…(1) Adrenal-sympathetic syndrome or paroxysmal hypertension, first described by Labbd et al (1922) and more recently reviewed by Mackeith (1944) and Blacklock et al (1947). (2) Persistent hypertension: a group of 51 such cases has been analysed by Green (1946).…”

mentioning

confidence: 99%

Chromaffin Tumour with Chronic Hypertension

Lumb¹

1951

BMJ

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Phæochromocytoma

Cited by 36 publications

References 40 publications

Chromaffin Reacting Cells in Human Digital Skin

Chromaffin Reacting Cells in Human Digital Skin

Case of Bilateral Phaeochromocytoma

Chromaffin Tumour with Chronic Hypertension

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