Phaeochromocytoma in pregnancy can mimic severe hypertensive disorders

Gainder, Shalini; Raveendran, Ainharan; Bagga, Rashmi; Saha, Soma; Dhaliwal, L. K.; Bhansali, Anil

doi:10.3109/01443615.2011.587909

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…The remaining suitable reports contained 77 women with phaeochromocytoma during pregnancy, involving 78 fetuses. Data are summarized in Tables 1 and 2 , and are available in full as an electronic supplementary file ( Table S1 , supporting information)5, 11–70.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of phaeochromocytoma in pregnancy

Biggar

Lennard

2013

Journal of British Surgery

107

102

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Section: Resultsmentioning

confidence: 99%

Systematic review of phaeochromocytoma in pregnancy

Biggar

Lennard

2013

Journal of British Surgery

107

102

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“…The symptoms are secondary to the production of catecholamines from chromaffin cells that make up the pheochromocytoma. The problem during pregnancy is especially diagnostic, because as a "great pretender," pheochromocytoma mime pre-eclampsia is the most common (4) . The clinical diagnosis of pheochromocytoma is not always easy during pregnancy (Table I) -a major complication in the case of late diagnosis -maternal and fetal worse prognosis…”

Section: Discussionmentioning

confidence: 99%

Pheochromocytoma and Pregnancy: a Case Report

Belaazri¹,

Lamine²,

siati³

et al. 2017

IAM

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Pheochromocytoma is the tumor of neural crest cells of adrenal gland secreting catecholamines. We report a case of a patient diagnosed with pheochromocytoma during her 2nd pregnancy at 17 week period of gestation. An obstetrical ultrasound scan confirmed fetal viability. The outcome was favorable after surgical resection. Pheochromocytoma diagnosed during pregnancy is rare. If undiagnosed, the maternofetal mortality is high. The diagnosis should be considered if there are evocative clinical signs or resistant gestational hypertension. The specific treatment is surgical resection.

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“…Hypertension accompanied by not only headaches, palpitations and sweating but also hyperglycemia or cardiomyopathy is suggestive of pheochromocytoma, whereas hypertension accompanied by proteinuria and edema is more suggestive for pregnancy-related hypertension (10,11). Finally, specific phenotypical features such as café-au-lait spots, freckles and fibromas might suggest a syndrome-based pheochromocytoma (8,12).…”

Section: Symptomsmentioning

confidence: 99%

ENDOCRINOLOGY IN PREGNANCY: Pheochromocytoma in pregnancy: case series and review of literature

Weerd

Noord

Loeve³

et al. 2017

European Journal of Endocrinology

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Pheochromocytoma in pregnancy is extremely rare. Early recognition is crucial as antepartum diagnosis can largely decrease maternal and fetal mortality rates. As symptoms of pheochromocytoma are rather similar to those of other far more common causes of hypertension during pregnancy, timely diagnosis is a challenge. In pregnant patients, similar to non-pregnant patients, increased plasma and/or 24-h urine (nor)metanephrine concentrations most reliably confirm the diagnosis of pheochromocytoma. MRI and ultrasound are the only imaging modalities that can be used safely during pregnancy to localize the tumor. During pregnancy, pretreatment consists of alpha blockade as usual. However, dosing of α-adrenergic receptor blockers during pregnancy is a challenge as hypertension must be treated while preserving adequate uteroplacental circulation. When the diagnosis is made within the first 24 weeks of pregnancy, it is generally recommended to remove the tumor in the second trimester, while resection is generally postponed till after delivery when the diagnosis is made in the third trimester and medical pretreatment is sufficient. Both during and after pregnancy, laparoscopic surgery is the preferred approach for resection of the tumor. There is no consensus in literature about the preferred route and timing of delivery. Therefore, in our opinion, decisions should be made on an individual basis by an experienced and dedicated multidisciplinary team. Over the last decades, maternal and fetal prognosis has improved considerably. Further increasing awareness of this rare diagnosis and treatment of these patients by a dedicated team in a tertiary referral hospital are critical factors for optimal maternal and fetal outcome.

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Phaeochromocytoma in pregnancy can mimic severe hypertensive disorders

Cited by 6 publications

References 16 publications

Systematic review of phaeochromocytoma in pregnancy

Systematic review of phaeochromocytoma in pregnancy

Pheochromocytoma and Pregnancy: a Case Report

ENDOCRINOLOGY IN PREGNANCY: Pheochromocytoma in pregnancy: case series and review of literature

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