Phaeohyphomycosis caused by Cladophialophora bantiana

Martínez-Lamas, Lucía; Álvarez, Manuel Penín; Llovo, J.; Gené, Josepa; Cano, J.

doi:10.1016/j.riam.2013.05.004

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…In cases of phaeohyphomycosis, the lesions mainly affected the brain, highlighting the isolated species C. bantiana as the main cause of severe brain infections due to its neurotropism, which can rarely cause disseminated infections (Martínez-Lamas et al 2014, Alves et al 2022). Among the clinical forms of aspergillosis in companion animals, nasal infection by Aspergillus sp., associated with sinusitis, has been the most frequent (Zhang et al 2012, Barrs & Talbot 2014, according to the clinical signs of a cat observed in this study.…”

Section: Discussionmentioning

confidence: 99%

Fungal diseases in dogs and cats in Northeastern Brazil

et al. 2023

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In this retrospective study, the clinical and anatomopathological findings of fungal diseases in dogs and cats in Northeastern Brazil are described. During the study period, 6,827 histopathological examinations (4,090 necropsies and 2,737 biopsies) of companion animals were reviewed, and fungal infections were diagnosed in 54 cases. Of these, 32 cases were diagnosed in cats and 22 in dogs. Sporotrichosis was the most prevalent mycosis (19/54), followed by dermatophytosis (9/54), cryptococcosis (8/54), candidiasis (7/54), and phaeohyphomycosis (4/54). Other diseases had two cases each, including aspergillosis, mucormycosis, and histoplasmosis, whereas coccidioidomycosis occurred once. Mycoses were diagnosed through microscopic lesions associated with the histomorphological characteristics of the agent, as evidenced by routine and special histochemical stains. They were occasionally confirmed by immunohistochemistry and microbiological cultivation. This retrospective study showed that despite being uncommon, fungal diseases are important causes of death in dogs and cats in the region, with cats being the most affected species and sporotrichosis being the most prevalent mycosis. Clinical signs were correlated with the portal of entry of the infection associated with localized or disseminated superficial and deep skin lesions or affecting parenchymal organs, especially in systemic infections. Microscopic lesions were mainly characterized by pyogranulomatous inflammation associated with fungal structures. In dogs, mycoses occurred mainly owing to an immunological impairment secondary to canine distemper virus co-infection.

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Section: Discussionmentioning

confidence: 99%

Fungal diseases in dogs and cats in Northeastern Brazil

et al. 2023

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“…It is the most common cause of central nervous system (CNS) infections caused by the dematiaceous pigmented fungi [5]. The pigmented nature of this organism has been shown to be due to melanin production, and this feature may assist the organism with evading host defenses [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…Although the portal of entry for infection is frequently obscure, many fungi are thought to be blood-borne from the lungs or intestines [7,8]. Primary infection in the middle ear and paranasal sinuses can subsequently spread to the CNS [8].…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Cerebral Pheohyphomycosis Caused by Cladophialophora bantiana Infection in a Solid Organ Transplant Patient: A Case Report and a Review of Literature

Yacoub¹,

Robinson²,

Onuorah³

et al. 2017

J Med Cases

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We present a case of a 60-year-old male with a past medical history of alpha-1-antitrypsin deficiency with lung transplantation in 2010, who was maintained on immunosuppressive agents, and was admitted to the hospital for neurological symptoms. Magnetic resonance imaging (MRI) of the brain revealed a ring-enhancing lesion. Microscopic evaluation of the abscess revealed fungus, and cultures grew Cladophialophora bantiana (C. bantiana). He was successfully treated with surgical abscess excision, liposomal amphotericin B and voriconazole.

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“…Treatment failure for the patient could be associated with intensive immunosuppressive therapy, bronchopneumonia, and his overall bad health status. Additionally, fungal brain abscess carries a poor prognosis, regardless of the underlying disease ( Revankar, 2011 ; Martínez–Lamas et al ., 2013 ).…”

Section: Discussionmentioning

confidence: 99%

First case of systemic phaeohyphomycosis due to Cladophialophora bantiana in Slovakia

Sládeková¹,

Poczova²,

Gašpar³

et al. 2014

JMM Case Reports

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Introduction:Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes. Cladophialophora bantiana is one of the most common and dangerous neurotropic fungi, able to cause brain abscess and disseminated infection.Case Presentation:We report a new case of phaeohyphomycosis brain abscesses caused by C. bantiana in Slovakia. The patient was a 63-year-old man having undergone heart transplantation, with dyspnoea, left-sided bronchopneumonia and fevers. CT (computed tomography) and MRI (magnetic resonance imaging) of the brain revealed numerous abscesses. Bacterial infection was proven by neither the growth of bacteria in culture nor the presence of bacterial antigens. Direct microscopy of the pus from the brain abscess showed Gram-positive hyphae. The isolate was finally identified as C. bantiana based on morphological and physiological features, and on DNA sequence analysis.Conclusion:In spite of appropriate therapy, neurological complications and accelerated respiratory insufficiency resulted in the patient’s death. Concerning clinical manifestation of the brain phaeohyphomycosis that can sometimes be a problem to distinguish from malignancy, physicians should also assume infection caused by this serious pathogen.

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Phaeohyphomycosis caused by Cladophialophora bantiana

Cited by 7 publications

References 15 publications

Fungal diseases in dogs and cats in Northeastern Brazil

Fungal diseases in dogs and cats in Northeastern Brazil

Successful Treatment of Cerebral Pheohyphomycosis Caused by Cladophialophora bantiana Infection in a Solid Organ Transplant Patient: A Case Report and a Review of Literature

First case of systemic phaeohyphomycosis due to Cladophialophora bantiana in Slovakia

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