Phaeohyphomycosis Caused by
            <i>Alternaria infectoria</i>
            in a Renal Transplant Recipient

Halaby, Teysir; Boots, Hans; Vermeulen, Anton H. M.; Ven, André van der; Beguin, Hugues; Hooff, Hans van; Jacobs, Jan

doi:10.1128/jcm.39.5.1952-1955.2001

Cited by 63 publications

(50 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8,10,13 Among the Alternaria species responsible for opportunistic infections in organ recipient patients, A. infectoria accounts for only a minority of cases reported over the past decade. 2,3,5,6,9,11,12,14,16,18 Figure 3. Microscopic examination following lactophenol blue staining (magnification ×1500).…”

Section: Discussionmentioning

confidence: 99%

“…7,16 Itraconazole is the most commonly used drug, followed by amphotericin B. [3][4][5]9 Itraconazole doses used range between 100 and 400 mg for 2-8 months in monotherapy regimens. 3,6,7 This case report is remarkable due to its clinical presentation with multiple nodules and vegetating tumours as well as the slow but successful response to monotherapy with high-dose itraconazole.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,5,6,9,11,12,14,16,18 Members of this genus are generally found in aerosols, in soil, or on plants, and are typically pathogenic only to immunocompromised hosts. 2,3,5,6,[8][9][10][11][12][13][14][15][16]18 Nevertheless, a few reports describing cutaneous infections among immunocompetent individuals have also been described. 17 The development and refinement of modern molecular biologic techniques have lead to a better genotypic characterization of dematiaceous species associated with phaeohyphomycosis, resulting in a better understanding of these infections over the past decade.…”

Section: Feohifomicosis Producida Por Alternaria Infectoria Con Presementioning

confidence: 99%

See 2 more Smart Citations

Phaeohyphomycosis caused by Alternaria infectoria presenting as multiple vegetating lesions in a renal transplant patient

Cunha

Amaro

Vieira

et al. 2012

Revista Iberoamericana de Micología

View full text Add to dashboard Cite

a b s t r a c tThe genus Alternaria is one of the most common black moulds and appears to be increasing as a causative agent of subcutaneous phaeohyphomycosis, particularly among immunosuppressed patients.A 53-year-old patient who had received a kidney transplant presented with multiple verrucous lesions on the distal extremities. Positive histopathology and cultures, in addition to rDNA ITS region sequencing, identified the fungal isolate as Alternaria infectoria. Oral itraconazole was administered for 10 months. A follow-up at 15 months demonstrated no signs of infection.Clinical manifestations of cutaneous alternariosis vary significantly and only a few cases have been described in the literature. Although optimal treatment options remain controversial, this case of phaeohyphomycosis was successfully treated with itraconazole monotherapy.© 2010 Revista Iberoamericana de Micología. Published by Elsevier España, S.L. All rights reserved.Feohifomicosis producida por Alternaria infectoria con presentación clínica de múltiples lesiones vegetantes en un paciente sometido a un trasplante renal r e s u m e n Las especies del género Alternaria son mohos ubicuos que se caracterizan por presentar colonias de color gris; parecen ser cada vez más frecuentes como agente causal de las feohifomicosis subcutáneas, en especial entre pacientes inmunocomprometidos. Un paciente de 53 años de edad, que se había sometido a un trasplante renal, consultó por presentar tumores verrugosos en el tercio distal de las extremidades. La histopatología y cultivo positivos, además de la secuenciación de la región de transcripción interna ITS del rDNA, permitieron la identificación del aislamiento fúngico como Alternaria infectoria. Se instauró tratamiento con itraconazol oral durante 10 meses y, a los 15 meses de seguimiento, se demostró la ausencia de signos de infección.Las manifestaciones clínicas de la alternariosis cutánea son muy variables y tan sólo se han descrito unos pocos casos en los que se presenta en forma de tumoraciones verrugosas. Aunque el tratamiento de elección sigue siendo motivo de controversia, el paciente presentado en este estudio fue tratado satisfactoriamente con itraconazol.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Feohifomicosis Producida Por Alternaria Infectoria Con Presementioning

confidence: 99%

See 1 more Smart Citation

Phaeohyphomycosis caused by Alternaria infectoria presenting as multiple vegetating lesions in a renal transplant patient

Cunha

Amaro

Vieira

et al. 2012

Revista Iberoamericana de Micología

View full text Add to dashboard Cite

show abstract

“…La diseminación sistémica con múltiples lesiones de piel e infiltración pulmonar también ha sido descrita para la especie A. infectoria 21 . El género Colletotrichum incluye varias especies.…”

unclassified

“…Cuando existe infección sistémica, la disminución de la inmunosupresión es necesaria, pero siempre debe asociarse a un antifúngico. Anfotericina B, por su nefrotoxicidad, debe ser utilizada en su formulación liposomal 21 . Para definir la mejor opción terapéutica siempre debe realizarse una prueba de susceptibilidad.…”

unclassified

Feohifomicosis causada por Colletotrichum gloeosporioides y Alternaria infectoria en un paciente trasplantado renal

Ogawa¹,

Reis²,

Godoy³

et al. 2014

Rev. chil. infectol.

View full text Add to dashboard Cite

Phaeohyphomycosis caused by Colletotrichum gloeosporioides and Alternaria infectoria in renal transplant recipientSeveral species of black fungi have been reported as agents of subcutaneous phaeohyphomycosis. Although most of these fungi are considered opportunistic pathogens, they play an important role in phaeohyphomycosis, a disease considered an emergent mycosis among solid organ recipients. We report a case of phaeohyphomycosis caused by Alternaria infectoria of the left hand and the 4 th finger of the right hand of a 68-year-old male who underwent a renal transplant 35 months before. The lesion was treated with surgical excision. One year later, the patient presented a new lesion on the 5 th finger of the right hand, but this time caused by Colletotrichum gloeosporioides that was also removed surgically. Both lesions did not relapse after being removed. Antifungal susceptibility testing was performed against five antifungal drugs (amphotericin B, itraconazole, flucytosine, fluconazole and voriconazole). Alternaria infectoria was resistant to all five drugs and C. gloeosporioides was sensitive only to amphotericin B and voriconazole. We emphasize the need of histopathologic and microbiologic studies of new lesions of phaeohyphomycosis, since in this case the same patient was infected twice by two different fungi.

show abstract

Cutaneous Diseases in the Transplant Recipient

Myers¹,

Martinez²

2006

Medical Care of the Liver Transplant Patient

View full text Add to dashboard Cite

Phaeohyphomycosis Caused by Alternaria infectoria in a Renal Transplant Recipient

Cited by 63 publications

References 22 publications

Phaeohyphomycosis caused by Alternaria infectoria presenting as multiple vegetating lesions in a renal transplant patient

Phaeohyphomycosis caused by Alternaria infectoria presenting as multiple vegetating lesions in a renal transplant patient

Feohifomicosis causada por Colletotrichum gloeosporioides y Alternaria infectoria en un paciente trasplantado renal

Cutaneous Diseases in the Transplant Recipient

Contact Info

Product

Resources

About