Phage Nanofibers Induce Vascularized Osteogenesis in 3D Printed Bone Scaffolds

Wang, Jianglin; Yang, Mingying; Zhu, Ye; Wang, Lin; Tomsia, Antoni P.; Mao, Chuanbin

doi:10.1002/adma.201400154

Cited by 220 publications

(201 citation statements)

References 39 publications

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“…1a, b shows the top and side view of the scaffold, and the results indicate that the strut thickness is only about 30 µm deviated from the designed 300 µm thickness. This interconnected porous scaffold could not only provide more space for newly formed bone tissue to connect with the scaffold, but also facilitate blood vessel and nerve formation [3,19]. The acid etching treatment was taken to wipe off the oxide layer on the surface of the porous titanium scaffold.…”

Section: Resultsmentioning

confidence: 99%

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Qian

Zeng

et al. 2017

Sci. China Mater.

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Construction of functional porous titanium scaffold is drawing ever growing attention, due to its effectiveness in solving the mechanical mismatch between titanium implant and bone tissue. However, the poor water permeability as well as the problem in achieving uniform surface modification inside scaffold hinders the further biomedical application of porous titanium scaffold. In this study, largescale functional TiO 2 nanostructures (nanonetwork, nanoplate and nanowire) were constructed on three-dimensional porous titanium scaffolds surface via an effective hydrothermal treatment method. These nanostructures increase the hydrophilicity of the titanium scaffold surface, facilitating the cell culture medium to penetrate into the inner pore of the scaffold. Zeta potential analyses indicate that the surface electrical properties depend on the nanostructure, with nanowire exhibiting the lowest potential at pH 7.4. The influence of the nano-functionalized scaffold on protein adsorption and cell adhesion was examined. The results indicate that the nano-functionalized surface could modulate protein adsorption and bone marrow derived mesenchymal stem cells (BMSCs) adhesion, with the nanowire functionalized porous scaffold homogeneously promoting protein adsorption and BMSCs adhesion. Our research will facilitate future research on the development of novel functional porous scaffold.

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Section: Resultsmentioning

confidence: 99%

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Qian

Zeng

et al. 2017

Sci. China Mater.

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“…Additionally, additive manufacturing enables the incorporation of drugs/proteins as well as cells during scaffold [32] manufacturing to produce very complex architecture similar to bone [37][38][39]. Therefore, additive manufacturing methodology is widely used for the formation of biological bone scaffolds.…”

Section: Formation Methods Of Bone Scaffoldsmentioning

confidence: 99%

Application of 3D printing technology in bone tissue engineering

Wang

Wei

et al. 2018

Bio-des. Manuf.

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“…For ARCAM A1 the resolution is ±0.4 mm based on the information in the user's manual. Irrespective of the above, compressive strength, endurance and elastic modulus can be optimized to ensure the long term success of the implant [1,[29][30][31][32]. Vascularization is another aspect that merits consideration during design, because vascularization promotes diffusion of nutrients that is necessary for cell proliferation and differentiation.…”

Section: Design Considerationsmentioning

confidence: 99%

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

Nune

Misra

2017

Sci. China Mater.

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We elucidate here the process-structure-property relationships in three-dimensional (3D) implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing. The conventional methods for processing of biomedical devices including freeze casting and sintering are limited because of the difficulties in adaptation at the host site and difference in the micro/macrostructure, mechanical, and physical properties with the host tissue. In this regard, EBM has a unique advantage of processing patient-specific complex designs, which can be either obtained from the computed tomography (CT) scan of the defect site or through a computeraided design (CAD) program. This review introduces and summarizes the evolution and underlying reasons that have motivated 3D printing of scaffolds for tissue regeneration. The overview comprises of two parts for obtaining ultimate functionalities. The first part focuses on obtaining the ultimate functionalities in terms of mechanical properties of 3D titanium alloy scaffolds fabricated by EBM with different characteristics based on design, unit cell, processing parameters, scan speed, porosity, and heat treatment. The second part focuses on the advancement of enhancing biological responses of these 3D scaffolds and the influence of surface modification on cell-material interactions. The overview concludes with a discussion on the clinical trials of these 3D porous scaffolds illustrating their potential in meeting the current needs of the biomedical industry.

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Phage Nanofibers Induce Vascularized Osteogenesis in 3D Printed Bone Scaffolds

Cited by 220 publications

References 39 publications

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Large-scale functionalization of biomedical porous titanium scaffolds surface with TiO2 nanostructures

Application of 3D printing technology in bone tissue engineering

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

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