Phagocytic killing of microorganisms by radical processes:consequences of the reaction of hydroxyl radicals with chloride yielding chlorine atoms

Sarán, Manfred; Beck‐Speier, Ingrid; Fellerhoff, Barbara; Bauer, Georg

doi:10.1016/s0891-5849(98)00187-7

Cited by 101 publications

(55 citation statements)

References 43 publications

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“…Our results also indicated that infertile men with a diagnosis of chronic prostatitis have significantly lower ROS-TAC scores than controls (55). Infertile men with varicoceles were also found to have high levels of ROS, low levels of TAC (27), and low ROS-TAC scores (95).…”

Section: Utility Of Seminal Oxidative Stress Test In the Infertility supporting

confidence: 61%

“…Such an oxidative burst is an early and effective defense mechanism for killing microbes in cases of infection (55). Sperm damage from ROS that is produced by leukocytes occurs if seminal leukocyte concentrations are abnormally high, such as in leukocytospermia (53), or if seminal plasma was removed during sperm preparation for assisted reproduction (56).…”

Section: Role Of Leukocytospermia In Excessive Ros Production In Semenmentioning

confidence: 99%

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Role of reactive oxygen species in the pathophysiology of human reproduction

Agarwal

Saleh

Bedaiwy

2003

Fertility and Sterility

1,286

909

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Objective: To summarize the role of reactive oxygen species (ROS) in the pathophysiology of human reproduction. Design: Review of literature. Setting: Fertility research center and obstetrics and gynecology department in a tertiary care facility. Result(s): ROS plays an essential role in the pathogenesis of many reproductive processes. In male-factor infertility, oxidative stress attacks the fluidity of the sperm plasma membrane and the integrity of DNA in the sperm nucleus. Reactive oxygen species induced DNA damage may accelerate the process of germ cell apoptosis, leading to the decline in sperm counts associated with male infertility. ROS mediated female fertility disorders share many pathogenic similarities with the ones on the male side. These similarities include a potential role in the pathophysiology of endometriosis and unexplained infertility. High follicular fluid ROS levels are associated with negative IVF outcomes, particularly in smokers. Moreover, oxidative stress may be responsible in hydrosalpingeal fluid mediated embryotoxicity as well as poor in vitro embryonic development. Conclusion(s):High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states. (Fertil Steril 2003;79:829 -43.

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Section: Utility Of Seminal Oxidative Stress Test In the Infertility supporting

confidence: 61%

Section: Role Of Leukocytospermia In Excessive Ros Production In Semenmentioning

confidence: 99%

Role of reactive oxygen species in the pathophysiology of human reproduction

Agarwal

Saleh

Bedaiwy

2003

Fertility and Sterility

1,286

909

View full text Add to dashboard Cite

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“…APF is a novel fluorescence probe which shows much more specific reactivity to an MPO product, hypochlorite (HClO − ), compared with other fluorescence probes such as 2′,7′-dicholorodihidrofluorescein (DCFH) (18). Moreover, MPO products, particularly HClO − , play an important role in the subsequent ROS generation in terms of interaction with NADPH oxidase (19). Hydroxyl radicals (OH • ), which have the highest oxidation potential among ROS, are formed by reaction between the neutrophil-derived superoxide (O2…”

Section: Discussionmentioning

confidence: 99%

Functional Polymorphism of the Myeloperoxidase Gene in Hypertensive Nephrosclerosis Dialysis Patients

et al. 2007

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“…These reactive oxygen and nitrogen species (ROS and RNS) are an important part of host-defense strategies of organisms to kill parasites (Saran et al, 1999) as they react with each other to produce other reactive species that are sometimes more effi cient than the oxidants themselves (Beckman;Koppenol, 1996). In this context, it has been recently suggested that ROS and RNS produced as a defense strategy may amplify the leishmanicidal activity in patients with cutaneous leishmaniasis (Kocyigit et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Leishmanicidal, antibacterial, and antioxidant activities of Caryocar brasiliense Cambess leaves hydroethanolic extract

Paula-Ju¹,

Rocha²,

Donatti³

et al. 2006

Rev. bras. farmacogn.

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RESUMO: "Atividades leishmanicida, bactericida e antioxidante do extrato hidroetanólico das folhas de Caryocar brasiliense Cambess". As atividades antimicrobiana e antioxidante do extrato hidroetanólico das folhas de Caryocar brasiliense foram estudadas. O extrato demonstrou efeito leishmanicida sobre formas promastigotas de Leishmania amazonensis e atividade bactericida sobre estirpes de bactérias patogênicas para o homem. Além disso, o extrato demonstrou relevante capacidade antioxidante, similar às atividades da vitamina C e da rutina. Unitermos:Caryocar brasiliense, Caryocaraceae, piqui, atividade leishmanicida, atividade antioxidante, DPPH, leishmaniose. ABSTRACT:The antimicrobial and antioxidant activities of the hydroethanolic extract from Caryocar brasiliense leaves were evaluated. The extract showed leishmanicidal effect against Leishmania amazonensis promastigote forms and bactericidal activity against some pathogenic bacteria. The extract also showed relevant antioxidant activity, similar to that of vitamin C and rutin.

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Phagocytic killing of microorganisms by radical processes:consequences of the reaction of hydroxyl radicals with chloride yielding chlorine atoms

Cited by 101 publications

References 43 publications

Role of reactive oxygen species in the pathophysiology of human reproduction

Role of reactive oxygen species in the pathophysiology of human reproduction

Functional Polymorphism of the Myeloperoxidase Gene in Hypertensive Nephrosclerosis Dialysis Patients

Leishmanicidal, antibacterial, and antioxidant activities of Caryocar brasiliense Cambess leaves hydroethanolic extract

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