Phagocytosis by Human Leucocytes. I. Effect of Fibrin on Phagocytosis of Staphylococci and of Encapsulated Pneumococci by Normal Human Leucocytes1

Balch, Henry H.; Spencer, Margaret T.

doi:10.1172/jci103007

Cited by 11 publications

(5 citation statements)

References 10 publications

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“…Data relating neutrophil count per cubic millimeter to mean ingestion of the (C+) strain I and the (C-) staphylococcal strain in individual malnourished patients are given in Table V. No consistent relation can be seen, confirming the observations noted in the previous paper (20) and also the findings of another group of investigators (17).…”

Section: Resultssupporting

confidence: 82%

“…identical with those found in the study of normal of (C n fC)subjects (20) and may be briefly summarized.…”

Section: Resultssupporting

confidence: 74%

“…The method, utilizing the roller tube technique, has been described in detail in the previous paper. Phagocytosis was measured in both coagulable and non-coagulable blood using a coagulase negative (C-) strain of staphylococcus and four coagulase positive strains (C+I, II, III, IV) used in the previous study (20).…”

Section: Methodsmentioning

confidence: 99%

“…This study was carried out in conjunction with the observations reported in the preceding paper. Data with reference to phagocytosis in normal subjects are taken from that paper (20).…”

mentioning

confidence: 99%

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Phagocytosis by Human Leucocytes. II. Relation of Nutritional Deficiency in Man to Phagocytosis1

Balch¹,

Spencer²

1954

J. Clin. Invest.

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Section: Resultssupporting

confidence: 82%

“…identical with those found in the study of normal of (C n fC)subjects (20) and may be briefly summarized.…”

Section: Resultssupporting

confidence: 74%

Section: Methodsmentioning

confidence: 99%

“…This study was carried out in conjunction with the observations reported in the preceding paper. Data with reference to phagocytosis in normal subjects are taken from that paper (20).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Phagocytosis by Human Leucocytes. II. Relation of Nutritional Deficiency in Man to Phagocytosis1

Balch¹,

Spencer²

1954

J. Clin. Invest.

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“…beings and animals. Several workers reported that the coagulase-positive staphylococcal strains were able to prevent phagocytosis and promote invasion (3,4,10). Rogers and Tompsett (18) declared that the strains could survive and grow in leukocytes while proceeding with their invasion.…”

mentioning

confidence: 99%

Virulence and immunity of Staphylococcus aureus BB and certain deficient mutants

Hasegawa¹,

Clemente²

1978

Infect Immun

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Coagulase-negative and deoxyribonuclease-negative mutants were isolated from Staphylococcus aureus BB by treatment with N-methyl-N'-nitro-N-nitrosoguanidine. Comparison of virulence (50% lethal dose) to mice of these six mutant strains and S. aureus BB was determined by both intravenous and intraperitoneal routes. The ratios of the 50% lethal dose of coagulase-negative mutants to that of the parental strain S. aureus BB ranged from 201 to 403 for intravenous infection and 30.7 to 52.7 for intraperitoneal infection. The virulence of deoxyribonuclease-negative mutants was essentially the same as that of S. aureus BB. When mice were immunized subcutaneously with live S. aureus BB or its deoxyribonuclease-negative mutants, the resulting protection against the intravenous challenge of S. aureus BB was remarkable. The ratios of the 50% lethal dose for the mice that were immunized by these strains to that for the untreated mice extended from 40.1 to 60.6 for intravenous infection and 6.61 to 11.5 for the intraperitoneal route. However, no effect against S. aureus BB challenge was shown in the mice that were immunized with coagulase-negative mutants. According to Bergey's Manual of Determinative Bacteriology (2), Staphylococcus aureus is coagulase and protein A positive; Staphylococcus epidermidis and Staphylococcus saprophyticus are both negative. Moreover, the former ferments mannitol anaerobically; the latter two do not. Among these species, S. aureus has been observed in diseased tissues and in pus obtained from human abscesses and has produced many kinds of extracellular toxins and enzymes. These include hemolysin, leucocidin, fibrinolysin, penicillinase, deoxyribonuclease (DNase), and phosphatase (14). Many papers have reported on the relationship between S. aureus isolated from clinical materials and its extracellular toxins and enzymes. Elston et al. (6) reported that 99.4% of the clinical S. aureus strains released coagulase, 98.8% of these coagulase-positive strains produced DNase, and 85.9% of these same coagulase-positive strains fermented mannitol. Forsgren (8) reported that 100% of the coagulase-positive strains produced DNase and 98.9% released protein A. Some studies have been made about the role of these toxins and enzymes and their relationship to the virulence of S. aureus in human t Journal article no. 8400 of the Michigan Agricultural Experiment Station.

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Celluläre und humorale „Abwehr“-Systeme und -Reaktionen

Fritze¹

1958

Ergebnisse Der Inneren Medizin Und Kinderheilkunde

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Phagocytosis by Human Leucocytes. I. Effect of Fibrin on Phagocytosis of Staphylococci and of Encapsulated Pneumococci by Normal Human Leucocytes1

Cited by 11 publications

References 10 publications

Phagocytosis by Human Leucocytes. II. Relation of Nutritional Deficiency in Man to Phagocytosis1

Phagocytosis by Human Leucocytes. II. Relation of Nutritional Deficiency in Man to Phagocytosis1

Virulence and immunity of Staphylococcus aureus BB and certain deficient mutants

Celluläre und humorale „Abwehr“-Systeme und -Reaktionen

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