2024
DOI: 10.3390/cimb46080462
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Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond

Amber Afzal,
Zobia Afzal,
Sophia Bizink
et al.

Abstract: Glioblastoma multiforme (GBM) is one of the deadliest human cancers with very limited treatment options available. The malignant behavior of GBM is manifested in a tumor which is highly invasive, resistant to standard cytotoxic chemotherapy, and strongly immunosuppressive. Immune checkpoint inhibitors have recently been introduced in the clinic and have yielded promising results in certain cancers. GBM, however, is largely refractory to these treatments. The immune checkpoint CD47 has recently gained attention… Show more

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