Phagocytosis of Candida Albicans by Polymorphonuclear Leukocytes from Normal and Diabetic Subjects

Ra, Jackson; Cs, Bryan; Ba, Weeks

doi:10.1007/978-1-4684-8914-9_4

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…7 Several parameters were evaluated to identify overt factors responsible for this increased colonization in diabetic patients. Although examination of total and differential white blood cell counts revealed no correlation to colonization status, the complex nature of the defense mechanisms against the Candida organism suggests that covert functional defects of neutrophils [15][16][17][18][19][20] or cell-mediated immunity [21][22][23][24] may play an important role in this population. Many patients with defects in neutrophil and macrophage function are susceptible to oral candidiasis.…”

Section: Discussionmentioning

confidence: 99%

Isolation of Candida albicans from oral cavity of type II diabetic subjects and its relationship to total and differential white blood cell count

Amin¹,

Sadiq

Saeed³

2014

Zanco J Med Sci

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Section: Discussionmentioning

confidence: 99%

Isolation of Candida albicans from oral cavity of type II diabetic subjects and its relationship to total and differential white blood cell count

Amin¹,

Sadiq

Saeed³

2014

Zanco J Med Sci

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“…Glucose can stimulate yeast proliferation and promote transformation to a more virulent stage. 50 Furthermore, in a study by Jackson et al, 51 blood leukocytes from patients with diabetes showed impaired phagocytosis toward a virulent C albicans strain, but not an avirulent strain, in contrast to no impairment of phagocytosis of neutrophils seen in patients without diabetes, regardless of strain virulence.…”

Section: Glucosementioning

confidence: 96%

Genital Mycotic Infections in Patients With Diabetes

Nyirjesy

Sobel

2013

Postgraduate Medicine

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Patients with diabetes, especially those with poorly controlled glycemia, are prone to developing genital mycotic infections-vulvovaginal candidiasis in women and Candida balanitis in men-the latter almost exclusively in uncircumcised men. Candida albicans is the most common pathogen causing balanitis and is also the dominant cause of vulvovaginal candidiasis in women with diabetes, although Candida glabrata is a prominent pathogen in women with type 2 diabetes mellitus. Candida glabrata is less virulent but also less susceptible to conventional antifungal treatment. High blood glucose levels promote yeast attachment and growth, and also interfere with immune responses in the host. In uncircumcised men, the moist, warm space underneath the foreskin is thought to promote yeast growth, especially when hygiene is poor. Several other risk factors have been identified that predispose to genital mycotic infections, including antibiotic use, corticosteroid use, immunosuppression, atopy, and, in women only, genetics, pregnancy, estrogen/oral contraceptive use, and select sexual behaviors (eg, orogenital sex). In patients with hyperglycemia, risk is increased for not only incident infection but also for recurrence, underscoring the key role of establishing and maintaining euglycemia in the management of genital mycotic infections in patients with diabetes. In addition to blood glucose control, first-line treatment involves either an antifungal cream/ointment (or suppository for women only) that is applied intravaginally by women and directly to the affected area(s) by men, or oral treatment, which infrequently causes systemic side effects. Antifungal treatment should also be offered to sexual partners of patients with diabetes with a genital mycotic infection if the partner is similarly infected. Given high efficacy rates, follow-up test-of-cure after the completion of treatment is generally unnecessary.

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“…Phagocytosis is considered to be an important defence factor in candida infections 68,59 . In vitro tests suggest that GTF may change hydrophobicity of yeast cells 61,62 and thereby decrease or inhibit phagocytosis.…”

Section: Germ Tube Formation As Virulence Factormentioning

confidence: 99%

Facts and myths on recurrent vulvovaginal candidosis—a review on epidemiology, clinical manifestations, diagnosis, pathogenesis and therapy

Rodrigues²,

et al. 2002

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Summary:Approximately three-quarters of all women will experience an episode of vulvovaginal candidosis at least once in their life and 5± 10% of them will have more than one attack. Women suffering from three to four attacks within 12 months will be diagnosed with recurrent vulvovaginal candidosis (RVVC). This review covers the large number of proposed aetiological factors for RVVC. The diagnosis of the condition made by conventional means by health providers is often false and is also often misdiagnosed by the affected woman herself. The review covers various methods of diagnosing RVVC and the current knowledge on potential pathogenetic mechanisms proposed for genital candida infections. Treatment of RVVC, including local and systemic antimicrobial therapy and behaviour modi® cation to decrease the risk of recurrences, are discussed. Recent knowledge on drug resistance in candida is also included.

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Phagocytosis of Candida Albicans by Polymorphonuclear Leukocytes from Normal and Diabetic Subjects

Cited by 5 publications

References 4 publications

Isolation of Candida albicans from oral cavity of type II diabetic subjects and its relationship to total and differential white blood cell count

Isolation of Candida albicans from oral cavity of type II diabetic subjects and its relationship to total and differential white blood cell count

Genital Mycotic Infections in Patients With Diabetes

Facts and myths on recurrent vulvovaginal candidosis—a review on epidemiology, clinical manifestations, diagnosis, pathogenesis and therapy

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