Phagocytosis of<i>Candida albicans</i>by rabbit alveolar macrophages and guinea pig neutrophils

Arai, Tadashi; Mikami, Yuzuru; Yokoyama, Koji

doi:10.1080/00362177785190261

Cited by 51 publications

(17 citation statements)

References 9 publications

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“…The candidicidal activity of adult rhesus AM in our study exceeds that reported in other experimental animals such as rabbits (33,34) and guinea pigs (35). We have compared the acridine orange method with the Giemsa staining method using adult rhesus AM and believe that our results are accurate.…”

Section: Resultscontrasting

confidence: 54%

The Ontogeny of Pulmonary Defenses: Alveolar Macrophage Function in Neonatal and Juvenile Rhesus Monkeys

et al. 1988

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ABSTRACT. Using the technique of bronchoalveolar lavage, we isolated alveolar macrophages (AM) from the lower respiratory tract of newborn (1-4 days of age), infant (6-10 days of age), juvenile (3-6 months of age), and adult rhesus monkeys. The AM thus obtained were assayed in vitro to determine their chemotactic, phagocytic, and candidicidal capabilities. The predominant (289%) cell type in bronchoalveolar lavage effluent in all ages was the AM. Chemotaxis, phagocytosis, and killing of Candida albicans were markedly impaired in neonatal AM as compared with those from infants, juveniles, and adults. AM chemotactic activity achieved normal adult values by 6 days of age. Phagocytosis, and to a lesser extent candidicidal activity, were significantly improved in 6-day-old animals, but adult levels were still not achieved even by 6 months of age.

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Section: Resultscontrasting

confidence: 54%

The Ontogeny of Pulmonary Defenses: Alveolar Macrophage Function in Neonatal and Juvenile Rhesus Monkeys

et al. 1988

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“…Evidence is available that PMN neutrophils kill yeast cells (Lehrer and Cline, 1969) and damage pseudohyphae (Diamond, Krzesicki and Wellington, 1978) and PMN leukocytes are often considered to be of primary importance in resistance to candidiasis (Rogers and Balish, 1977;Hurtrel et al, 1980b). However, macrophages have been shown to inhibit growth of Candida (Peterson and Calderone, 1977) although some engulfed yeast cells germinate and grow out of macrophages (Ozato and Uesaka, 1974;Arai, Mikami and Yokoyama, 1977). Activated macrophages have been shown to kill a large percentage of ingested candida yeast cells (Maiti, Kumar and Mohapatra, 1980) and Evron ( 1 980) has suggested that macrophages play a protective role in systemic candidiasis.…”

Section: Discussionmentioning

confidence: 99%

Tissue responses to the blastospores and hyphae of Candida albicans in the mouse

Evans

1981

Journal of Medical Microbiology

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SUMMARY. Separate groups of mice challenged intravenously with either the blastospore or hyphal forms of the same strain of Candida albicans were examined for comparative mortality rates, organ localisation, and tissue and cellular response to the organisms. Blastospores were more rapidly and consistently fatal to mice than the hyphae. Relatively more hyphal elements than blastospores were initially localised in the lungs but more blastospores than hyphal elements were trapped in the liver. The cells of both forms were more effectively killed in the lungs than in other organs. Blastospores initially found in the kidneys increased rapidly in numbers, but hyphal inocula either grew slowly in the kidneys or were eliminated. After mice were challenged with either hyphae or blastospores the initial inflammatory response in the lungs and liver was predominantly of polymorphonuclear leukocytes, but macrophages were the first inflammatory cells to be seen in kidney sections. Peripheral blood counts showed a leukocytosis in mice of both groups although only blastospores resulted in increased numbers of circulating atypical lymphocytes. The results indicated that lungs may play a more important role than other reticuloendothelial organs in innate resistance to vascular invasion by either of the morphological forms of C. albicans, and macrophages may be crucial to host resistance to renal invasion by this fungus.

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“…It has long been recognized that phagocytic cells are essential for recovery from systemic candidiasis [6,7], and they have recently been shown to play an important part in clearance of oral infection [8]. In vivo, the response to infection involves not only recruitment and activation of phagocytic cells, but also increased production by the bone marrow.…”

Section: Introductionmentioning

confidence: 99%

Bone marrow colony-formation in vitro after infection of genetically defined inbred mice with Candida albicans

Wanasaengsakul

Ashman

2004

Microbial Pathogenesis

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The effect of C. albicans infection on the production of haematopoietic precursor cells in the bone marrow of CBA/CaH and BALB/c mice was evaluated by assay of colony formation in vitro. In immunocompetent mice, neither systemic nor oral infection induced significant alterations in colony formation by bone marrow from the two mouse strains, and Candida infection did not alter the proportion of morphological cell types in the colonies. However, the number of neutrophil-like was relatively greater in colonies derived from acutely infected CBA/CaH nude mice than in those from BALB/c nude mice, whereas small mononuclear cells were present in higher proportions in the latter strain. In both strains of nude mice, there was an increase in colony formation at 6 days after oral infection, but at 8 weeks, when the infection had become chronic, the production of bone marrow cells by CBA/CaH nude mice was significantly less than that by BALB/c nude mice. Reconstitution of nude mice with syngeneic lymphocytes enhanced the production of bone marrow precursor cells by BALB/c, but not by CBA/CaH mice, suggesting that T cells can enhance host resistance by promoting the colony-forming response of the bone marrow in BALB/c mice that are genetically resistant to tissue damage, but not in CBA/CaH that are prone to severe lesions. Finally, culture with Candida antigen in vitro decreased the number of colony-forming cells in cultures from CBA/CaH, but not from BALB/c mice.

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Phagocytosis ofCandida albicansby rabbit alveolar macrophages and guinea pig neutrophils

Cited by 51 publications

References 9 publications

The Ontogeny of Pulmonary Defenses: Alveolar Macrophage Function in Neonatal and Juvenile Rhesus Monkeys

The Ontogeny of Pulmonary Defenses: Alveolar Macrophage Function in Neonatal and Juvenile Rhesus Monkeys

Tissue responses to the blastospores and hyphae of Candida albicans in the mouse

Bone marrow colony-formation in vitro after infection of genetically defined inbred mice with Candida albicans

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