Phantom sensations of internal organs

Dorpat, Theodore L.

doi:10.1016/0010-440x(71)90053-8

Cited by 34 publications

(17 citation statements)

References 15 publications

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“…Ulcer pain has been reported to persist after vagotomy (Szasz 1949) or subtotal gastrectomy with removal of the ulcer (Gloyne 1954). Similarly, patients have reported labor pain and menstrual cramps following total hysterectomy (Dorpat 1971), rectal and hemorrhoid pain following removal of the rectum (Ovesen et al 1991), the burning pain of cystitis after complete removal of the bladder (Brena and Sammons 1979), and the pain of a severely ulcerated cornea after enucleation of an eye (Minski 1943).…”

Section: Pain In Phantom Limbs and Deafferented Structuresmentioning

confidence: 99%

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

Coderre

Katz

Vaccarino

et al. 1993

Pain

1,829

703

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SummaryPeripheral tissue damage or nerve injury often leads to pathological pain processes, such as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all possible tissue healing has occurred. Although peripheral neural mechanisms, such as nociceptor sensitization and neuroma formation, contribute to these pathological pain processes, recent evidence indicates that changes in central neural function may also playa significant role. In this review, we examine the clinical and experimental evidence which points to a contribution of central neural plasticity to the development of pathological pain. We also assess the physiological, biochemical, cellular and molecular mechanisms that underlie plasticity induced in the central nervous system (eNS) in response to noxious peripheral stimulation. Finally, we examine theories which have been proposed to explain how injury or noxious stimulation lead to alterations in eNS function which influence subsequent pain experience.

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Section: Pain In Phantom Limbs and Deafferented Structuresmentioning

confidence: 99%

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

Coderre

Katz

Vaccarino

et al. 1993

Pain

1,829

703

View full text Add to dashboard Cite

show abstract

“…However, phantom sensations have also been reported after mastectomy (Staps et al, 1985;Björkman et al, 2008), testis resection (Pühse et al, 2010), teeth extraction (Marbach, 1978), eye enucleation (Sörös et al, 2003), and even surgical removal of internal organs (Dorpat, 1971;Arcadi, 1977;Ovesen et al, 1991).…”

Section: Functional Reorganization Related To Nonpainful Phantom Phenmentioning

confidence: 99%

Functional Expansion of Sensorimotor Representation and Structural Reorganization of Callosal Connections in Lower Limb Amputees

Simões¹,

Bramati²,

Rodrigues³

et al. 2012

J. Neurosci.

115

117

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Previous studies have indicated that amputation or deafferentation of a limb induces functional changes in sensory (S1) and motor (M1) cortices, related to phantom limb pain. However, the extent of cortical reorganization after lower limb amputation in patients with nonpainful phantom phenomena remains uncertain. In this study, we combined functional magnetic resonance (fMRI) and diffusion tensor imaging (DTI) to investigate the existence and extent of cortical and callosal plasticity in these subjects. Nine "painless" patients with lower limb amputation and nine control subjects (sex-and age-matched) underwent a 3-T MRI protocol, including fMRI with somatosensory stimulation. In amputees, we observed an expansion of activation maps of the stump in S1 and M1 of the deafferented hemisphere, spreading to neighboring regions that represent the trunk and upper limbs. We also observed that tactile stimulation of the intact foot in amputees induced a greater activation of ipsilateral S1, when compared with controls. These results demonstrate a functional remapping of S1 in lower limb amputees. However, in contrast to previous studies, these neuroplastic changes do not appear to be dependent on phantom pain but do also occur in those who reported only the presence of phantom sensation without pain. In addition, our findings indicate that amputation of a limb also induces changes in the cortical representation of the intact limb. Finally, DTI analysis showed structural changes in the corpus callosum of amputees, compatible with the hypothesis that phantom sensations may depend on inhibitory release in the sensorimotor cortex.

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“…The other man had severe pain of the phantom penis. Phantom bladders and rectums have the same quality of reality (Bors, 1951;Dorpat, 1971). The bladder may feel so real that patients, after a bladder removal, sometimes complain of a full bladder and even report that they are urinating.…”

Section: Phantom Limb Phenomenamentioning

confidence: 99%