Pharmaceutical and biological availability of sustained release preparations of potassium chloride

A comparative study of the action of erosion on non disintegrating theophylline tablets was performed in the three USP XX dissolution models, the rotating basket, the paddle and the modified disintegration apparatus, as well as in a new (sandwich) model. The results show erosion to be dependent on the mechanical strength of the tablets and to be promoted by the phenomenon of softening of the tablets during the process of dissolution. A considerable and moderate erosion was found for 'soft' tablets in the rotating basket and disintegration apparatus, respectively, whereas no or only slight erosion was observed in the paddle and sandwich models. The phenomenon of dissolution intensified erosion and erosion intensified dissolution is shown to affect the description of the release profiles. The dissolution profiles of the 'hard' tablets in the models preferred to be described by the square root equation, whereas the profiles of the 'soft' tablets in the case of erosion showed a tendency to a better fit with the cube root of mass versus time relation.

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Studies on different dissolution models

Dehaan

Lerk

1982

Pharmaceutisch Weekblad Scientific Edition

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A single blind normal volunteer bioavailability study of a new microencapsulated potassium chloride tablet compared with two reference potassium formulations

Caplain¹,

Pamphile

et al. 1991

European Journal of Drug Metabolism and Pharmacokinetics

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A single blind placebo controlled, cross-over study comparing a new microencapsulated potassium chloride tablet (MET) with two reference formulations of oral potassium, potassium chloride solution (PS) and potassium chloride wax-matrix tablets (WMT), was performed in 12 normal healthy volunteers. Urinary potassium excretion was the main criterion of comparison. Results showed that all three formulations have excellent bioavailability. This indicates that potassium absorption in the stomach is similar to that in more distant portions of the gut. The slow-release characteristics of both MET and WMT were confirmed. Clinical and pharmacological tolerance was excellent and no side-effects were reported with any of the potassium formulations studied.

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Development and bioequivalence study of potassium chloride extended release tablets

Thi

Quan

2018

Asian Journal of Pharmaceutical Sciences

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Pharmaceutical and biological availability of sustained release preparations of potassium chloride

Cited by 3 publications

References 6 publications

Studies on different dissolution models

Studies on different dissolution models

A single blind normal volunteer bioavailability study of a new microencapsulated potassium chloride tablet compared with two reference potassium formulations

Development and bioequivalence study of potassium chloride extended release tablets

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