Pharmaceutical and biomedical applications of starch-based drug delivery system: A review

Sivamaruthi, Bhagavathi Sundaram; Nallasamy, Prakashkumar; Suganthy, Natarajan; Kesika, Periyanaina; Chaiyasut, Chaiyavat

doi:10.1016/j.jddst.2022.103890

Cited by 31 publications

(8 citation statements)

References 120 publications

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“…in plant-based meat alternatives 37 , that was recently criticized due to its synthetic nature 37 , as it is manufactured by heating cellulose with a caustic solution (such as sodium hydroxide) and subsequently treating it with methyl chloride 38 . STC, on the other hand, is a naturally occurring edible polymer with the same various applications in the food industry as thickener, stabilizer and binder, is also used as a hydrogel-polymer 58 and a drug delivery system 59 . Although we could show that both of the substances were exerting a significant positive effect on BSCs proliferation, and in case of MC the stability of HGF was greatly improved, there seemed to be no specific binding of the GFs and stabilizers, as it is known for other well described stabilizers of GFs, e.g.…”

Section: Discussionmentioning

confidence: 99%

Never let me down: new possibilities for lowering serum free cultivation media costs

Schenzle

Egger

Fuchs

et al. 2022

Preprint

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Cultivated meat may be a more ethical, environmentally friendly, antibiotic-free meat alternative of the future. As of now, one of the main limiting factors for bringing cultivated meat to the market is the high cost of the cell culture medium. Here, we optimize B8/B9 medium - one of the well-established serum free, fully defined medium compositions available for purchase or for preparation in-house. We show several combinations of the growth factors/myokines/hormones, which were able to substantially increase bovine satellite cells’ proliferation rate, as well as treatment schemes which allow to use five to ten times lower concentrations of signaling molecules for the same effect. Additionally, we present two food grade low-price medium stabilizers, one of which exhibits superior stabilization of the B8 medium as compared to recombinant human serum albumin, and allows for its substitution, dropping the price for stabilization to approx. under 0.2% of that used in B9 medium.

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Section: Discussionmentioning

confidence: 99%

Never let me down: new possibilities for lowering serum free cultivation media costs

Schenzle

Egger

Fuchs

et al. 2022

Preprint

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“…It has been widely used in the pharmaceutical industry due to its physical and chemical properties. In pharmaceutical formulations, it is used as tablets and capsules, as diluent, binder, and lubricant [62,63]. [65,66].…”

Section: Starchmentioning

confidence: 99%

Renewable Polymers in Biomedical Applications: From the Bench to the Market

Lopes,

Nossa,

Lustri

et al. 2024

JRM

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Polymers from renewable resources have been used for a long time in biomedical applications and found an irreplaceable role in some of them. Their uses have been increasing because of their attractive properties, contributing to the improvement of life quality, mainly in drug release systems and in regenerative medicine. Formulations using natural polymer, nano and microscale particles preparation, composites, blends and chemical modification strategies have been used to improve their properties for clinical application. Although many studies have been carried out with these natural polymers, the way to reach the market is long and only very few of them become commercially available. Vegetable cellulose, bacterial cellulose, chitosan, poly(lactic acid) and starch can be found among the most studied polymers for biological applications, some with several derivatives already established in the market, and others with potential for such. In this scenario this work aims to describe the properties and potential of these renewable polymers for biomedical applications, the routes from the bench to the market, and the perspectives for future developments.

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“…Starch is another glucose-based biopolymer synthesized by plants. Differently from cellulose, the starch glucose monomers are linked by α-glycosidic bonds ( Figure 2 ) to form linear or branched chains named amylose and amylopectin, respectively [ 236 ]. It is generally extracted from plant seeds, roots, and tubers through steps of physical separation that progressively eliminate cellulose, proteins, and other impurities [ 237 ].…”

Section: Functionalization Of Msns With Biopolymersmentioning

confidence: 99%

“…Limitations, mainly related to the heterogeneity and agglomeration tendency of natural starch, affect the performance of the biopolymer in drug delivery applications. Thus, several chemical and biochemical modifications to obtain starch derivatives with improved solubility and reactivity have been implemented [ 236 ].…”

Section: Functionalization Of Msns With Biopolymersmentioning

confidence: 99%

Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery

et al. 2023

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In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature leakage and site-specific controlled release. New nanotechnological approaches have been developed with the objective of utilizing natural biopolymers as smart materials in drug delivery applications. Natural biopolymers are sensitive to various physicochemical and biological stimuli and are endowed with intrinsic biodegradability, biocompatibility, and low immunogenicity. Their use as biocompatible smart coatings has extensively been investigated in the last few years. This review summarizes the MSNs coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs, which conjugate the nanocarrier features of mesoporous silica with the biocompatibility and controlled delivery provided by natural coatings, have shown promising therapeutic outcomes and the potential to emerge as valuable candidates for the selective treatment of various diseases.

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Pharmaceutical and biomedical applications of starch-based drug delivery system: A review

Cited by 31 publications

References 120 publications

Never let me down: new possibilities for lowering serum free cultivation media costs

Never let me down: new possibilities for lowering serum free cultivation media costs

Renewable Polymers in Biomedical Applications: From the Bench to the Market

Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery

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