This study explores the Narcotic Drugs and Psychotropic Substances Act of 1985 (NDPS Act) and its enforcement in South India. It provides a nuanced understanding of the Act's application through an analysis of legal provisions, case studies, and regional practices. The research focuses on regulatory frameworks, law enforcement strategies, and the societal impact of drug control policies in the southern states of India, highlighting the multifaceted nature of these policies. The findings emphasize the importance of context- specific approaches in drug regulation and enforcement. The NDPS Act, enacted by the Government of India, addresses the illicit trafficking and abuse of narcotic drugs and psychotropic substances. It regulates activities related to these substances, including production, manufacture, possession, sale, purchase, transport, warehousing, use, consumption, and inter-state and international trade. This comprehensive legislation plays a crucial role in shaping drug control strategies and has significant implications for both legal enforcement and social dynamics within the region.