Pharmaceutical and Pharmacological Evaluation of the Effect of Nano-Formulated Spironolactone and Progesterone on Inflammation and Hormonal Levels for Managing Hirsutism Experimentally Induced in Rats

Ezetimibe-Loaded Nanostructured Lipid Carrier for Oral Delivery: Response Surface Methodology; In Vitro Characterization and Assessing the Antihyperlipidemic Effect in Rats

“…It was observed that the zeta potential of different EZ-NLC formulations held negative charges and ranged from −22.05 ± 2.96 to −39.95 ± 2.26 mV as shown in Table . These negatively charged values were promising and provided good qualities of long-term stability and particle adhesion; besides, they might be related to the carboxylic group of free fatty acids (FFA) in the structure of lipids used in the formulations. , …”

“…Consequently, they significantly extend the residence period of therapeutic molecules in the systemic circulation. 28 The statistical analysis of the particle size revealed significant effects of liquid lipid type and liquid lipid percentage on the response with (p-value <0.0001) for both independent variables. The positive coefficient of B in the equation displayed in Table 1 refers to the direct relationship between the percentage of liquid lipid with respect to total lipid amount (LL%w/w) and the PS as observed from Table 2 and Figure 1a.…”

“…These negatively charged values were promising and provided good qualities of long-term stability and particle adhesion; besides, they might be related to the carboxylic group of free fatty acids (FFA) in the structure of lipids used in the formulations. 24,28 The statistical analysis of ZP for different EZ-NLC formulations demonstrated significant impacts of a (p-value = 0.0121) and B (p-value = 0.0005) upon the response. It was observed from Figure 1b that the formulations prepared using oleic acid displayed larger values of ZP compared to IPM as indicated by the positive coefficient of a[1].…”

“…Then, the samples were subjected to a heating rate of 10 °C/min under dry nitrogen purge at a rate of 25 mL/min and a temperature range of 25 to 300 °C to record the change in enthalpy. 7,28 3.2.4.4. MTT Cytotoxicity Assay.…”

Formulation and characterization of thiolated chitosan/polyvinyl acetate based microneedle patch for transdermal delivery of dydrogesterone

“…Microneedle patches (MN-P) can deviate in terms of various constructed features like the aspect of length, tip diameter, base diameter, needle-to-needle spacing, and array dimensions ( Elahpour et al, 2021 ). Dydrogesterone (DYD) is a synthetic progesterone analogue being widely used in the therapy of several gynaecological disorders ( Amer et al, 2021 ). However, oral DYD intake is accompanied with poor bioavailability owing to minimal water solubility and extensive hepatic first-pass metabolism ( Sharma et al, 2021 ).…”