Pharmaceutical Applications of Aerogels

Smirnova, Irina; García-González, Carlos A.; Gurikov, Pavel

doi:10.1007/978-3-030-27322-4_59

Cited by 2 publications

(2 citation statements)

References 94 publications

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“…Especially due to the possibility of external shaping e. g. by doctor blading, the processability and hence applicability of these materials might possibly be even higher than in conventionally synthesized gels. In this context, the application of these materials can be expanded to include: all kind of catalysis (e. g., water electrolysis, gas‐phase catalysis and photocatalysis), biomedical applications for diagnostics and analysis (e. g., analysis of pharmaceuticals and bioactive molecules), environmental applications (e. g., adsorbent in water treatment), and last but not least, in the field of electronics as insulators, conductors, supercapacitors or further high‐surface electrodes [1,123–127] …”

Section: Discussionmentioning

confidence: 99%

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Borg,

Morales,

Dorfs

et al. 2024

ChemNanoMat

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Cryogels have morphological features that make them interesting for several applications such as catalysis, sensing or tissue engineering. Their interconnected network and open porous structure, build up by primary particles (such as inorganic nanocrystals or polymers), provide these materials with unique physical properties and high specific surface areas. While the library of cryogels is endless, widely used in the polymer chemistry field, in this review we will summarize the structure and properties, applications and challenges of inorganic nanocrystal‐based cryogels obtained by freezing and freeze‐drying an aqueous nanoparticle colloid. This fast, easy and versatile gelation method will be outlined, along with the corresponding macro‐, micro‐ and nano‐structures and gel morphologies that can be obtained, for example, by changing the freezing temperature or by using one nanoparticle system or nanoparticle mixtures. Their applications towards electrocatalysis, photocatalysis and photoelectrochemical sensing will be highlighted, as well as the challenges and prospects of these materials.

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Section: Discussionmentioning

confidence: 99%

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Borg,

Morales,

Dorfs

et al. 2024

ChemNanoMat

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“…Calcium alginate aerogels have promising uses in drug delivery, wound treatment and food preservation (Budtova, 2023;Smirnova et al, 2023). Alginates are linear polysaccharides usually extracted from brown algae.…”

Section: Introductionmentioning

confidence: 99%

Wetting of alginate aerogels, from mesoporous solids to hydrogels: a small-angle scattering analysis

Balogh,

Kalmár,

Gommes

2024

J Appl Crystallogr

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Mesoporous polysaccharide aerogels are versatile functional materials for drug delivery and wound dressing devices. The hydration and wetting of these aerogels control their application-related performance, e.g. the release of encapsulated drugs. Reported here is a detailed small-angle neutron scattering (SANS) analysis of the hydration mechanism of a calcium alginate aerogel, based on mathematical modelling of the scattering. The model accounts for the hierarchical structure of the material comprising a mesoporous structure, the solid skeleton of which is made up of water-swollen polymers. At large scale, the mesoporous structure is modelled as a random collection of elongated cylinders, which grow in size as they absorb water and aggregate. The small-scale inner structure of the skeleton is described as a Boolean model of polymer coils, which captures the progressive transition from a dense dry polymer to a fully hydrated gel. Using known physico-chemical characteristics of the alginate, the SANS data are fitted using the size of the cylinders as the only adjustable parameter. The alginate aerogel maintains a nanometre-scale, albeit altered, structure for low water contents but it collapses into micrometre-sized structures when the water content approaches one gram of water per gram of alginate. In addition to the wetting of aerogels, the model might be useful for the small-angle scattering analysis of the supercritical drying of gels.

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Pharmaceutical Applications of Aerogels

Cited by 2 publications

References 94 publications

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Nanoparticle‐Based Cryogels from Colloidal Aqueous Dispersion: Synthesis, Properties and Applications

Wetting of alginate aerogels, from mesoporous solids to hydrogels: a small-angle scattering analysis

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