Pharmaceutical applications of Aloe vera

Abstract

Aloe vera has been used as folk medicine for a host of therapeutic indications of which the inner gel is the component extensively used and studied. Proponents of the use of this plant suggest that it is easily available, economical, and have fewer side effects compared to commercial drug compounds. However, the active constituents and their exact mechanisms have yet to be fully elucidated. This review focuses on the identification of the active constituents and their functional mechanism in the areas of anti-diabetic, anti-inflammatory, wound healing, and antibacterial. Preliminary evidence was found to support the antidiabetic effect which extended to the early stages of the disease with no adverse effects at the dosages used. Although topical application for its anti-inflammatory effect may be delayed and minute, oral administration has shown a significant response. However, too high a dose has been linked with an initial inflammatory reaction. Favorable response to the gel has also been demonstrated to support the use of A. vera in wound-healing and as an antibacterial agent, although limited to simple, uncomplicated wounds. Different active constituents such as acemannan and aloin have been suggested for the effects of the plant and this may be interpreted as synergism among different compounds rather than the action of a single compound. Until robust evidence is available, the plant should only be used as an adjunct to other wellestablished evidence-based treatment modalities.

Ozonated Aloe vera Oil Effective Increased the Number of Fibroblasts and Collagen Thickening in the Healing Response of Full-Thickness Skin Defects

“…The results of this study indicated that collagen in the full-thickness defect treated with ozonated Aloe vera oil is thicker than that treated with Aloe vera oil and gentamicin ointment. Ozonated Aloe vera oil increases reactive oxygen species (ROS) and reactive nitrogen species (RNS) around the wound site, such as platelets, macrophages, fibroblasts, endothelial cells, and keratinocytes that act as wound healing radicals [ 7 ]. Fibroblasts around the wound site will produce collagen, which is an undifferentiated mesenchymal cell.…”

Herbal Medication of Recurrent Aphthous Stomatitis: A Narrative Review

“…Aloe vera can be used to heal internal and external wounds, such as skin wounds, burns, itching, and stomatitis. 18 Aloe vera also contains natural salicylates and a few substances with the ability to inhibit the production of inflammatory mediators such as bradykinin and thromboxane. The chrysophanic acid, seristanol, and cinnamic acid esters in Aloe vera are antiseptic 26 .…”

PEMBEKALAN HAND HYGIENE DAN PELATIHAN PEMBUATAN HAND SANITIZER LIDAH BUAYA (Aloe vera L.) DI SMA NEGERI 1 UNGARAN KABUPATEN SEMARANG

“…Lidah buaya memiliki aktivitas aktibakteri spektrum luas, baik untuk menghambat bakteri gram positif maupun negatif. Ekstrak lidah buaya dengan pelarut berbeda akan mempengaruhi potensi aktivitas antibakteri (Heng et al, 2018).…”

“…Mekanisme antibakteri lidah buaya diduga disebabkan karena efek sinergisme berbagai kandungan tanaman seperti anthraquinone, aloin, aloeemodin, chromones, aloeresin D, dan isoaloeresin D. Kandungan lain seperti pyrocathecol, cinnamic acid yang merupakan kelompok fenolik, pcoumaric acid, asam askorbat juga mendukung aktivitas antibakteri. Kandungan fitokimia yang telah teridentifikasi seperti saponin, glikosida, alkaloid, saponin dan tannin merupakan kandungan aktif yang berpotensi sebagai antibakteri (Heng et al, 2018 Dari hasil observasi dan tanya jawab bahwa pemahaman tentang CTPS terbatas tahu tentang CTPS, tetapi belum dapat menyebutkan dengan benar terkait langkah cuci tangan yang baik dan benar sesuai dengan anjuran dari WHO. Siswasiswi mendukung jika CTPS merupakan hal yang baik dan bermanfaat.…”