Pharmaceutical applications of mucoadhesion for the non-oral routes

Edsman, Katarina; Hägerström, Helene

doi:10.1211/0022357055227

Cited by 155 publications

(98 citation statements)

References 177 publications

(198 reference statements)

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“…It is a unidirectional drug flow preventing all kinds of unwanted drug loss. The Figure 3 shows various types of buccal dosage forms [29]. …”

Section: General Considerations In Designing Dosage Formsmentioning

confidence: 99%

Review on Mucoadhesive Drug Delivery System with Special Emphasis on Buccal Route: An Important Tool in Designing of Novel Controlled Drug Delivery System for the Effective Delivery of Pharmaceuticals

Singh¹,

Sharma²,

Garg³

2017

J Dev Drugs

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Since, the last four decades, the concept of mucoadhesion has achieved a much valuable interest in the various fields of pharmaceutics. There are many advantages of mucoadhesive buccal drug delivery system that made this a novel drug delivery system for the local as well as systemic delivery of various drugs. The main advantage of this drug delivery system is that it prolongs the residence time of the dosage form at the site of application. Due to the high blood supply and relatively high permeability of the buccal mucosa, the buccal cavity is the best option for both local as well as systemic delivery of various drugs. The term bioadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the midst layer of surface of a biological membrane and the natural or synthetic polymers, which allows the polymer to adhere the surface of that membrane for an extended as well as prolonged period of time. In this review we have discussed the various types of mucoadhesive dosage forms along with a brief knowledge about the various types of mucoadhesive polymers. The buccal mucoadhesive dosage forms can be either of matrix or of reservoir types. The main advantage of this route for drug delivery is that, the delivery by this route by passes the first pass metabolism of various drugs that are prone to the their hepatic first pass metabolism. This review provides the brief knowledge about the oral mucosal drug delivery by discussing briefly the structural features of mucosa, mechanism of bioadhesion, various theories of bioadhesion, general considerations in design of mucoadhesive buccal dosage forms, permeation enhancers, and the various evaluation methods along with the literature survey of the buccal mucoadhesive drug delivery system.

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“…It is a unidirectional drug flow preventing all kinds of unwanted drug loss. The Figure 3 shows various types of buccal dosage forms [29]. …”

Section: General Considerations In Designing Dosage Formsmentioning

confidence: 99%

Review on Mucoadhesive Drug Delivery System with Special Emphasis on Buccal Route: An Important Tool in Designing of Novel Controlled Drug Delivery System for the Effective Delivery of Pharmaceuticals

Singh¹,

Sharma²,

Garg³

2017

J Dev Drugs

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“…Cp, drug concentration in plasma; Cm, drug concentration in perfusion medium; Ka, first-order absorption rate constant; F, fraction of disappeared drug transferred to circulating blood; K12 and K21, first order transfer rate constants between two compartment K10 first order elimination rate constant: Vdc distribution volume of control compartment; Vdt distribution volume of peripheral compartment 17,18 .…”

Section: Pharmacokinetic Model For Salicylic Acid In Dogsmentioning

confidence: 99%

Untitled

2011

IJPSR

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Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for prolonged time by mucoadhesive binding. The close contact with absorption membrane causes more absorption of the drug. The pH of buccal cavity ranges between 5-7, and does not cause any problem to the drug with the right dosage form design and formulation; the permeability and the local environment of the mucosa can be controlled and manipulated in order to accommodate drug permeation. Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules. The objective of this article is to review mucosa as a route for drug delivery by discussing the structure, environment, permeability, dynamics etc. of the buccal mucosa and the materials used for oral permeation enhancers.

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“…The five theories that are most commonly presented in conjunction with bioadhesion are the absorption, diffusion, electronic, fracture and wetting theories. 24) For dry dosage forms, wetting, hydration and swelling of the dosage form will initiate the intimate contact with the tissue. Secondly, there will be an interpenetration of the components, the polymers of the dosage form and the mucus gel network on the surface of the tissue, across the interface.…”

Section: Effect Of Pectins On the Characteristics Of B-lf Tabletsmentioning

confidence: 99%

Influence of Pectins on Preparation Characteristics of Lactoferrin Bioadhesive Tablets

Takeda

Seto

Kawano

et al. 2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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Chronic inflammation of the oral mucosa and gingiva is often observed accompanying intractable stomatitis.1) The stomatitis reduces the quality of life of patients because it brings intense pain and anorexia. The severity and duration of stomatitis are greatly influenced by immune responses and oral hygiene condition. 2)Lactoferrin, an iron-binding glycoprotein that consists of a single polypeptide chain, is an abundant protein in milk secretions.3) Lactoferrin is found in most exocrine secretions including tears, nasal secretions, saliva, intestinal mucus and genital secretions, 4,5) and is also identified as one of the major proteins present in neutrophils. 6) Lactoferrin shows its bactericidal effect by binding with iron ions that are essential for the growth of bacteria, [7][8][9] and also acts as a modulator for various immunologic functions.10) The bactericidal effect and the immune regulatory function of lactoferrin should act to prevent the deterioration of stomatitis. Previously, we prepared buccal adhesive tablets consisting of bovine lactoferrin (B-LF), pectin and xylitol and evaluated the ulcer healing effect of the tablets by using rats induced with buccal mucosal ulcer. From the results, the ulcer decreased significantly at the seventh day in the group treated with the B-LF tablets as compared with the untreated group. (The in vivo data was presented on the 125th annual meeting of the Pharmaceutical Society of Japan, 2005).Pectins are ionic plant polysaccharides that are widely used in the food industry for their gelling properties. Their main structural features consist of blocks of (1→4)-linked homogalacturonan interrupted by single (1→2)-linked rhamnose units. [11][12][13] The homogalacturonan blocks are copolymers of galacturonic acid and its methyl ester, and the degree of esterification characterizes the gelation of pectins. Fifty % or more of the carboxyl groups are methyl esterified in native pectins. They are categorized as highly methylated pectins (HM pectins). Pectins of lower ester content (LM pectins) can be prepared by controlled acid deesterification.14) As shown in Fig. 1, LM pectins readily form gels in aqueous solution by cross-linking with free Ca 2ϩ . [15][16][17][18] In this study, we attempted to investigate the influence of the degree of esterification and the molecular weight of pectins on the characteristics of B-LF bioadhesive tablets, because preparation characteristics such as bioadhesive force and B-LF release properties may influence the ulcer healing effect. Pectins of various degrees of esterification and LM pectins cross-linked with Ca 2ϩ were used to prepare B-LF bioadhesive tablets, and the usefulness of the pectins as a bioadhesive polymer were evaluated. Shinagawa-ku, Tokyo 142-8501, Japan. Received February 22, 2007; accepted May 12, 2007; published online May 14, 2007 For the treatment of chronic inflammation in the oral cavity, we attempted to develop bioadhesive tablets of bovine lactoferrin (B-LF). Pectin was used as a bioadhesive polymer, and the inf...

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Pharmaceutical applications of mucoadhesion for the non-oral routes

Cited by 155 publications

References 177 publications

Review on Mucoadhesive Drug Delivery System with Special Emphasis on Buccal Route: An Important Tool in Designing of Novel Controlled Drug Delivery System for the Effective Delivery of Pharmaceuticals

Review on Mucoadhesive Drug Delivery System with Special Emphasis on Buccal Route: An Important Tool in Designing of Novel Controlled Drug Delivery System for the Effective Delivery of Pharmaceuticals

Untitled

Influence of Pectins on Preparation Characteristics of Lactoferrin Bioadhesive Tablets

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