With the rapid development of high-throughput sequencing technology and the continuous progress of data analysis methods, genomics provides new perspectives and tools for the prevention of cardiovascular diseases. This study elaborates on the important role and potential impact of genomics in the prevention of cardiovascular diseases. Research has found that genomics not only helps guide drug selection and dosage adjustment, but also provides guidance for lifestyle interventions, thereby helping individuals reduce the risk of cardiovascular disease. By conducting in-depth research on the association between genes and cardiovascular disease, it is possible to accurately identify high-risk individuals and develop targeted prevention strategies. However, the application of genomics also faces ethical, privacy, technological, and legal challenges. In the future, with the continuous innovation of technology and the reduction of costs, genomics is expected to play a greater role in the prevention of cardiovascular diseases and make important contributions to human health.