Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment

Nakada, Norihide; Tanishima, Toshikatsu; Shinohara, Hiroyuki; Kiri, Kentaro; Takada, Hideshige

doi:10.1016/j.watres.2006.06.039

Cited by 664 publications

(393 citation statements)

References 23 publications

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“…Background concentrations of pharmaceuticals were considered negligible as compared to the spiked concentrations based on reported values in wastewater influents (e.g. Joss et al ., 2005; Nakada et al ., 2006) and previous characterization of Ann Arbor WWTP influent (Stadler et al ., 2014). Quantification was performed using a matrix‐matched calibration curve (Fig.…”

Section: Methodsmentioning

confidence: 83%

“…In addition to conventional pollutants, however, thousands of pharmaceuticals are excreted by humans in intact and metabolized forms, reaching WWTPs before being released into the environment (Kolpin et al ., 2002). The ability of the microbes in WWTPs to biotransform these chemicals is an area of great interest (Carballa et al ., 2004; Castiglioni et al ., 2005; Nakada et al ., 2006; Kasprzyk‐Hordern et al ., 2009). Substantial research has advanced our knowledge of pharmaceutical biotransformation pathways (Ellis et al ., 2006) and the transformation products formed during treatment (Kern et al ., 2010).…”

Section: Introductionmentioning

confidence: 99%

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Elucidating the impact of microbial community biodiversity on pharmaceutical biotransformation during wastewater treatment

Stadler

Vela

Jain

et al. 2017

Microbial Biotechnology

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SummaryIn addition to removing organics and other nutrients, the microorganisms in wastewater treatment plants (WWTPs) biotransform many pharmaceuticals present in wastewater. The objective of this study was to examine the relationship between pharmaceutical biotransformation and biodiversity in WWTP bioreactor microbial communities and identify taxa and functional genes that were strongly associated with biotransformation. Dilution‐to‐extinction of an activated sludge microbial community was performed to establish cultures with a gradient of microbial biodiversity. Batch experiments were performed using the dilution cultures to determine biotransformation extents of several environmentally relevant pharmaceuticals. With this approach, because the communities were all established from the same original community, and using sequencing of the 16S rRNA and metatranscriptome, we identified candidate taxa and genes whose activity and transcript abundances associated with the extent of individual pharmaceutical biotransformation and were lost across the biodiversity gradient. Metabolic genes such as dehydrogenases, amidases and monooxygenases were significantly associated with pharmaceutical biotransformation, and five genera were identified whose activity significantly associated with pharmaceutical biotransformation. Understanding how biotransformation relates to biodiversity will inform the design of biological WWTPs for enhanced removal of chemicals that negatively impact environmental health.

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Section: Methodsmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Elucidating the impact of microbial community biodiversity on pharmaceutical biotransformation during wastewater treatment

Stadler

Vela

Jain

et al. 2017

Microbial Biotechnology

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“…In the present study, the specic TP removal rates varied between 0.81 and 1.07 mg per mg chl a per day, which are higher than the values (0.2-0.52 mg per mg chl a per day) reported by Aslan and Kapdan. 21 In addition, the specic TN removal rates (12.13-17.53 mg per mg chl a per day) were also found to be signicantly higher than the specic NH 4 -N removal rates (peak value: 3.0 mg per mg chl a per day) in which NH 4 Cl was used as the nitrogen source. 21 The observed high specic TP and TN removal rates in the present study are due to the low initial chl a concentration (0.05 mg L À1 ), much lower than the value (3.5 mg L À1 ) reported by Aslan and Kapdan.…”

Section: Removal Of Nutrientsmentioning

confidence: 95%

“…[1][2][3][4] Thus discharge of untreated wastewater should be avoided as it could pose risks to the environment and public health. In many countries, domestic wastewater has oen been treated by various types of conventional wastewater treatment technologies such as activated sludge process and oxidation ditch by making use of microbial processes.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous removal of inorganic and organic compounds in wastewater by freshwater green microalgae

Zhou

Ying

Liu

et al. 2014

Environ. Sci.: Processes Impacts

143

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Batch experiments were carried out for 7 days to investigate the simultaneous removal of various organic and inorganic contaminants including total nitrogen (TN), total phosphorus (TP), metals, pharmaceuticals and personal care products (PPCPs), endocrine disrupting chemicals (EDCs), and estrogenic activity in wastewater by four freshwater green microalgae species, Chlamydomonas reinhardtii, Scenedesmus obliquus, Chlorella pyrenoidosa and Chlorella vulgaris. After treatment for 7 days, 76.7-92.3% of TN, and 67.5-82.2% of TP were removed by these four algae species. The removal of metals from wastewater by the four algae species varied among the metal species. These four algae species could remove most of the metals efficiently (>40% removal), but showed low efficiencies in removing Pb, Ni and Co. The four algae species were also found to be efficient in removing most of the selected organic compounds with >50% removal, and the estrogenic activity with removal efficiencies ranging from 46.2 to 81.1% from the wastewater. Therefore, algae could be harnessed to simultaneously remove various contaminants in wastewater. Environmental impactDomestic wastewater contains various inorganic and organic contaminants, which could pose risks to the environment and public health. To avoid these adverse effects, wastewater must be treated prior to its nal discharge into the receiving environment. Unfortunately, incomplete removals have oen been reported for these contaminants in wastewater by conventional wastewater treatment technologies. The use of microalgae in the treatment of wastewater has gained great interest over the past few years. However, previous studies on wastewater treatment by algae have been limited and most of them are focused on the removal of inorganic or organic pollutants in articial wastewaters. This study investigated the simultaneous removal capacity of inorganic (nitrogen, phosphorus and metals) and organic pollutants (PPCPs and EDCs) by four freshwater microalgae, and also evaluated the elimination of estrogenic activity in the wastewater by these algae species. The results demonstrated that simultaneous removal of various contaminants in wastewater was achieved, which showed potential application of these algae species in the wastewater treatment.

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“…Because conventional wastewater treatment processes are not specifically designed for the effective removal of pharmaceuticals, the secondary effluent and the sludge of wastewater treatment plants (WWTPs) have been proven to be an important pollution source of pharmaceuticals (Nakada et al, 2006;Vieno et al, 2007). Nowadays, serious concerns have been raised regarding the occurrence of pharmaceuticals in the environment due to an increasing reuse of wastewater effluent and excess sludge (e.g., landscape irrigation, crop irrigation, biofertilizer) (Sabourin et al, 2012;Wu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of multiple class pharmaceuticals in both municipal wastewater and sludge with ultra high performance liquid chromatography tandem mass spectrometry

Yuan

Qiang

Ben

et al. 2014

Journal of Environmental Sciences

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Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment

Cited by 664 publications

References 23 publications

Elucidating the impact of microbial community biodiversity on pharmaceutical biotransformation during wastewater treatment

Elucidating the impact of microbial community biodiversity on pharmaceutical biotransformation during wastewater treatment

Simultaneous removal of inorganic and organic compounds in wastewater by freshwater green microalgae

Rapid detection of multiple class pharmaceuticals in both municipal wastewater and sludge with ultra high performance liquid chromatography tandem mass spectrometry

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